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Alzheimer's disease (AD) cannot be completely cured at present.
Existing treatment methods, such as the commonly used drug treatment of brain amyloid (Aβ), can only moderately alleviate the symptoms of AD and slow down its pathological progress.
AD is a neurodegenerative disease with complex and multipathological features.
How to simultaneously treat pathological symptoms such as Aβ deposition and achieve nerve regeneration to improve cognitive impairment is a challenge for AD treatment.
Wang Qiangbin, a researcher at the Suzhou Institute of Nanotechnology and Nanobionics, Chinese Academy of Sciences, and his team designed a multifunctional neural stem cell (NSC) treatment strategy that combines genes, drugs and stem cells.
This strategy can simultaneously achieve Aβ clearance and promote nerves in a mouse model.
Regeneration and repair, and showed a good effect on improving the memory and cognition of AD mice (Figure 1).
The experiment developed a genetically engineered NSCs (NEP-NSCs) that can stably and continuously express enkephalinase (NEP), which can release NEP to achieve efficient and sustained degradation of Aβ in the brain microenvironment, and maintain the balance of Aβ metabolism , While promoting the survival of NSCs; on this basis, in order to overcome the adverse reactions related to the pathological microenvironment of AD and promote the neuronal differentiation of NEP-NSCs, a PBAE-PLGA- with high-efficiency gene/drug delivery efficiency was constructed experimentally.
Ag2S-RA-siSOX9 (PPAR-siSOX9) nano-pharmaceuticals, which can promote the differentiation of NEP-NSCs into neurons by synergistically regulating the Wnt/β-catenin and RA signaling pathways and inhibit their differentiation into glial cells; based on Ag2S quantum dots Near-infrared zone II fluorescence can also realize real-time imaging guidance for NEP-NSCs transplantation, and realize accurate transplantation of NEP-NSCs in the hippocampus (Figure 2).
Benefiting from the advantages of long-lasting degradation of Aβ, nerve regeneration and repair, and precise cell transplantation, this strategy has shown good short-term and long-term AD curative effects.
The water maze behavior of AD mice after a single treatment for 1 and 6 months The analysis showed good memory and cognitive improvement (Figure 3).The development of this technology provides a new idea for the development and application of multifunctional stem cell therapies that can deal with many diseases of AD.
Related research results were published on Advanced Materials with the title A Nanoformulation-Mediated Multifunctional Stem Cell Therapy with Improved Beta-Amyloid Clearance and Neural Regeneration for Alzheimer's Disease.
Postdoctoral researcher Huang Dehua is the first author of the paper, and Wang Qiangbin and project researcher Chen Guangcun are the corresponding authors of the paper.
Research work has been funded by the National Natural Science Foundation of China's key and general projects, the original innovation project of the Chinese Academy of Sciences' Basic Frontier Scientific Research Program "from 0 to 1", and the national key research and development program.
Figure 1.
Schematic diagram of multifunctional stem cell therapy.
Figure 2.
Genetically engineered NEP-NSCs and their function verification.
Figure 3.
Behavioral analysis of AD mouse water maze.
A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the fatal changes do not occur in the brain, but in the intestines.
.
.
9.
The ultra-large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight and restored the old brain to a young state.
.
.
Existing treatment methods, such as the commonly used drug treatment of brain amyloid (Aβ), can only moderately alleviate the symptoms of AD and slow down its pathological progress.
AD is a neurodegenerative disease with complex and multipathological features.
How to simultaneously treat pathological symptoms such as Aβ deposition and achieve nerve regeneration to improve cognitive impairment is a challenge for AD treatment.
Wang Qiangbin, a researcher at the Suzhou Institute of Nanotechnology and Nanobionics, Chinese Academy of Sciences, and his team designed a multifunctional neural stem cell (NSC) treatment strategy that combines genes, drugs and stem cells.
This strategy can simultaneously achieve Aβ clearance and promote nerves in a mouse model.
Regeneration and repair, and showed a good effect on improving the memory and cognition of AD mice (Figure 1).
The experiment developed a genetically engineered NSCs (NEP-NSCs) that can stably and continuously express enkephalinase (NEP), which can release NEP to achieve efficient and sustained degradation of Aβ in the brain microenvironment, and maintain the balance of Aβ metabolism , While promoting the survival of NSCs; on this basis, in order to overcome the adverse reactions related to the pathological microenvironment of AD and promote the neuronal differentiation of NEP-NSCs, a PBAE-PLGA- with high-efficiency gene/drug delivery efficiency was constructed experimentally.
Ag2S-RA-siSOX9 (PPAR-siSOX9) nano-pharmaceuticals, which can promote the differentiation of NEP-NSCs into neurons by synergistically regulating the Wnt/β-catenin and RA signaling pathways and inhibit their differentiation into glial cells; based on Ag2S quantum dots Near-infrared zone II fluorescence can also realize real-time imaging guidance for NEP-NSCs transplantation, and realize accurate transplantation of NEP-NSCs in the hippocampus (Figure 2).
Benefiting from the advantages of long-lasting degradation of Aβ, nerve regeneration and repair, and precise cell transplantation, this strategy has shown good short-term and long-term AD curative effects.
The water maze behavior of AD mice after a single treatment for 1 and 6 months The analysis showed good memory and cognitive improvement (Figure 3).The development of this technology provides a new idea for the development and application of multifunctional stem cell therapies that can deal with many diseases of AD.
Related research results were published on Advanced Materials with the title A Nanoformulation-Mediated Multifunctional Stem Cell Therapy with Improved Beta-Amyloid Clearance and Neural Regeneration for Alzheimer's Disease.
Postdoctoral researcher Huang Dehua is the first author of the paper, and Wang Qiangbin and project researcher Chen Guangcun are the corresponding authors of the paper.
Research work has been funded by the National Natural Science Foundation of China's key and general projects, the original innovation project of the Chinese Academy of Sciences' Basic Frontier Scientific Research Program "from 0 to 1", and the national key research and development program.
Figure 1.
Schematic diagram of multifunctional stem cell therapy.
Figure 2.
Genetically engineered NEP-NSCs and their function verification.
Figure 3.
Behavioral analysis of AD mouse water maze.
A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the fatal changes do not occur in the brain, but in the intestines.
.
.
9.
The ultra-large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight and restored the old brain to a young state.
.
.
