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Alzheimers Dementia: Primary progressive aphasia combined with pathology, with more pronounced neurological degeneration

 Last Update: 2021-06-08
 Source: Internet
 Author: User

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Primary progressive aphasia (PPA) is a clinical dementia syndrome characterized by an isolated defect in understanding or expressing language at the beginning and will decline over time.

This ambiguity makes it difficult for people to make realistic expectations about the rate of disease progression, which affects the family’s ability to formulate appropriate care plans to meet these challenges.

And use the Activity of Daily Living Questionnaire (ADLQ) to measure functional decline, the questionnaire is designed to assess the daily function of dementia patients.

Given that the atrophy patterns of suspected AD pathology reported in the PPA are more extensive, it is beneficial to predict:

Participants with AD biomarkers (PPAAβ+) will show greater obstacles in activities of daily living at baseline and over time than participants without AD biomarkers (PPAAβ-).

Based on previous work in clinical samples without biomarkers, it can also be speculated that both groups will experience declines in functional activities other than communication, especially over time.

They used a linear mixed-effects model to compare the activity of daily living questionnaire (ADLQ) scores of 17 PPAAβ+ and 11 PPAAβ- participants, who had suspected potential lesions every 6 months for 2 years.

A general linear model examines the association between functional decline at baseline and cortical thickness.

They found that there were no differences in demographics and severity of aphasia between the groups, but in each interval of 18 months, the total and subdomain scores of PPAAβ+ were significantly worse than those of PPAAβ- (P = 0.

However, in each interval of 18 months, the total ADLQ score and subdomain scores of PPAAβ+ were significantly worse than those of PPAAβ- (P = 0.

It is found that compared with the neuropathological manifestations of non-AD, patients with non-semantic PPA (combined with AD pathology) seem to have more significant functional decline and destroy more aspects of life activities.

Moeller S, Sridhar J, Martersteck A, Coventry C, Kuang A, Zhang H, Weintraub S, Mesulam MM, Rogalski E.
Functional decline in the aphasic variant of Alzheimer's disease.
Alzheimers Dement.
2021 Apr 8.
doi: 10.
1002/alz.
12331.
Epub ahead of print.
PMID: 33829622.

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