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The future can be expected!
Time of Update: 2021-05-22
Global burden of disease studies show that more than 1 billion people are currently affected by neurodegenerative diseases, and nearly 7 million people die from these diseases every year.
Kristen's mother was diagnosed with Huntington's disease when she was 9 years old.
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Once bitten, twice shy!
Time of Update: 2021-05-22
On April 30, 2021, Professor Zhu Dongya's research group from the School of Pharmacy of Nanjing Medical University published an article in Molecular Psychiatry, revealing that the coupling effect of nNOS-CAPON in the prefrontal cortex negatively regulates the dissipative learning process of fear memory.
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There are too many classifications of headaches, hard to remember!
Time of Update: 2021-05-22
*Only for medical professionals to read for reference. This article gives a systematic summary of painful cranial neuropathy and other facial pain and other types of headaches. Clinically, there a
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Maoxing Biotech's new CAR-T treatment of glioma has made breakthroughs in clinical research | Yimai Meng broke the news
Time of Update: 2021-05-22
Shang Xiaoyun, founder and CEO of Maoxing Biotechnology, the company's new CAR-T cells have achieved such breakthrough results in solid tumors, mainly due to the following three points: (1) Allogeneic universal CAR-T technology: this The core raw material of the product-T cells are collected from healthy volunteers.
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This performance of mesencephalic infarction is unexpected, and the positioning is unexpected!
Time of Update: 2021-05-22
Figure 2: MRI of the head; DWI shows the high signal in front of the aqueduct at the lower part of the right midbrain level, and the ADC phase low signal localization diagnosis: the patient mainly presents with bilateral trunk and limb ataxia and dysarthria.
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PNAS: Can "high education" not delay brain aging?
Time of Update: 2021-05-22
Just now, in a new study published in the Proceedings of the National Academy of Sciences (PNAS), an international research team led by the University of Oslo in Norway found through brain scans of more than 2,000 people that education level can delay aging of the brain and There is no protection.
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Where does abstract classification thinking come from?
Time of Update: 2021-05-22
The study shows that mice have super abstract ability, so they have complex thinking, and reveal the neural basis related to classification learning.
Sandra Reinert and Pieter Goltstein with Mark Hübener, research group leader of the Max Planck Institute for Neurobiology, and Tobias Bonhoeffer, director , Studied how the brain stores abstract information like learned classification.
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Ischemic stroke is terrible, but recurrence is even more terrible!
Time of Update: 2021-05-22
*It is only for medical professionals to read for reference. Keeping learning is a kind of literacy! As the most common type of stroke, ischemic stroke accounts for up to 80% of strokes in my countr
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Roche satelizumab was approved in China, saying NO to the recurrence of optic neuromyelitis spectrum disease!
Time of Update: 2021-05-22
Studies have shown that in adult patients with AQP4 antibody-positive NMOSD, compared with placebo, subcutaneous injections are given every 4 weeks, whether it is satelizumab combined immunotherapy or satelizumab single agent Treatment can effectively reduce the risk of recurrence and has good safety.
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The Lancet is heavy!
Time of Update: 2021-05-22
Patients with moderate to severe upper limb dysfunction caused by stroke (at least 9 months after ischemic stroke) were randomly assigned into two groups, each combined with vagus nerve stimulation The rehabilitation treatment group (VNS group) combined with false stimulation (control group).
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Image manifestations of 10 common lesions in the brainstem area, a summary
Time of Update: 2021-05-22
Chronic phase: The hematoma is completely absorbed, forming a cyst similar to cerebrospinal fluid, which is manifested as T1W low signal; T2W is high signal.
5 MRI manifestations of inflammation: T1W low signal, T2W high signal, enhanced after enhancement.
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Guidelines for the diagnosis and treatment of dementia in Alzheimer's disease in China are released.
Time of Update: 2021-05-22
1 Recommendations for Comprehensive Cognitive Evaluation in Clinical Evaluation ➤ Simple Mental State Examination (MMSE) has high performance in detecting dementia, with acceptable accuracy for mild cognitive impairment (MCI), and the best threshold and educational adjustments have been established Value (2B).
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Supranuclear palsy, subacute combined degeneration, gray matter heterotopia|3 minute reading•26 period
Time of Update: 2021-05-22
" Case 3 is a middle-aged male patient with recurrent seizures and disturbance of consciousness for 20 years, and was admitted to the hospital for another 2 days.
MRI is as follows: Answer: Dyke-Davidoff-Masson Syndrome (DDMS, Da-Dai-Marco Syndrome) is a rare central nervous system disease and a common cause of cerebral hemiplegia .
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A new method of immunotherapy for children with high-grade glioma—comments on the latest NEJM article from Professor Zhang Yizhu’s team
Time of Update: 2021-05-22
The results of this study show that oncolytic virus immunotherapy has good safety in children with high-grade gliomas, no serious adverse reactions or signs of virus replication in the body, and treatment-related side effects are slightly controllable; the median of patients The survival time was significantly extended to 12.
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Cell Stem Cell | lamin B1 mediates the intrinsic regulatory mechanism of age-dependent changes in hippocampal neural stem cell activity
Time of Update: 2021-05-22
This short article reveals the intrinsic regulatory mechanism of the age-dependent changes in hippocampal neural stem cell activity mediated by lamin B1, and shows that selective overexpression of LB1 in the neurogenic lineage is sufficient to enhance neurogenesis in vivo and save the elderly neural stem cells.
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A stroke after waking up?
Time of Update: 2021-05-22
Qualitative diagnosis: the patient is elderly male, with acute onset, past history of pulmonary heart disease, long-term smoking history, ECG monitoring after admission indicates atrial fibrillation, there are multiple high-risk factors for cerebrovascular disease, head CT excludes bleeding and space occupation, first consider acute Ischemic cerebrovascular disease-basilar artery tip syndrome (TOBS), the mechanism of cardiogenic embolism may be possible, and secondly, the possibility of infection, poisoning, metabolic disorder, etc.
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Cell Journal: Bao Lan/Wang Bin reveals the molecular mechanism of axon-enriched long non-coding RNA regulating axon growth
Time of Update: 2021-05-22
On May 4, 2021, Researcher Bao Lan from the Center for Excellence in Molecular Cell Science (Institute of Biochemistry and Cell Biology), Chinese Academy of Sciences, and Associate Researcher Wang Bin from the Shanghai Brain Science and Brain-like Research Center, as co-corresponding authors, are in the Cell Reports journal Published online research paper titled: Axon-enriched lincRNA ALAE is required for axon elongation via regulation of local mRNA translation.
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Express | Better than the approved DMD therapy, the new generation of oligonucleotide therapy Phase 2 clinical results are positive
Time of Update: 2021-05-22
▎Editor of WuXi AppTec's content team On May 3, 2021, Sarepta Therapeutics announced its new generation antisense oligonucleotide therapy SRP-5051 for the treatment of patients with Duchenne muscular dystrophy (DMD).
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Milestone in the treatment of muscular dystrophy: single-base editing allows muscle stem cells to develop into muscle fibers
Time of Update: 2021-05-22
The research team took a sample of muscle tissue from a 10-year-old patient and isolated muscle stem cells, then cultured these stem cells in vitro, and used single-base editing (Base Editing) technology to replace the base pairs at the mutation site.
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NEUROBIOL AGING: Obesity is related to decreased cerebral blood flow, but exercise can be improved!
Time of Update: 2021-05-22
Recently, a study published in the journal Neurobiology of Aging showed that being overweight or obese can greatly reduce blood flow in the brain, but increasing physical exercise can positively change or even offset this decrease in cerebral blood flow.
