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Cell Death Differ: The interaction between Hevin and calcyon can promote synaptic reorganization after brain injury
Time of Update: 2021-04-13
In this study, the researchers determined that the neuron-specific vesicle protein calcyon is a new type of interaction protein of hevin, and confirmed that this interaction plays a key role in the reorganization of synapses after mature brain injury.
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Cholesterol may be the key to new treatments for Alzheimer's disease, diabetes
Time of Update: 2021-04-13
Recently, a study published in the journal ACS Pharmacology & Translational Science, health science researchers from the University of Arizona discovered the role of cholesterol in the treatment of Alzheimer’s disease and type 2 diabetes, and found a way to help Small molecules that regulate cholesterol in the brain are expected to become potential targets for the treatment of Alzheimer's disease.
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J Neurochem: Cerebral blood flow connectivity can be used as a prognostic biomarker for subcortical stroke imaging
Time of Update: 2021-04-13
The study also found that the underlying mechanism of short-term memory impairment in patients with subcortical stroke is the decrease in CBF CBF of the affected insula and the interruption of the connection in the contralateral frontal lobe network.
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After 16 years of suffering from headaches, I was dealt with by a needle, so amazing?
Time of Update: 2021-04-13
The First Affiliated Hospital of Zhejiang University School of Medicine received the treatment and did not relapse afterwards, so he rushed to the Zhijiang District of the First Hospital of Zhejiang University with Guo Zi. It turned out to be "cluster headache"I can finally open my eyes after "a shot"Chief physician Feng Zhiying, director of the Department of Pain at the First Hospital of Zhejiang University, received Guo Zi.
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70 million people worldwide suffer from autism!
Time of Update: 2021-04-13
An investigation by The Wall Street Journal also showed that under the new crown epidemic, due to the lack of relevant medical professionals , it is particularly difficult to diagnose and treat patients with intellectual development disorders such as autism .
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Acta Neuropathologica: The heterogeneity of alpha-synuclein fibril activity in patients with Lewy body dementia is related to disease phenotype
Time of Update: 2021-04-13
1007/s00401-021-02288-1" target="_blank" rel="noopener"> -synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.
1007/s00401-021-02288-1" target="_blank" rel="noopener"> -synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.
1007/s00401-021-02288-1" target="_blank" rel="noopener"> -synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.
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Dev Cogn Neurosci: Adolescent alcohol use disorder and cannabis use disorder symptoms are related to neural prediction error signals and responses to novelties
Time of Update: 2021-04-13
Higher AUDIT scores are related to reduced modulation of RPE in the ventral putamen (under the threshold of looseness) and attention areas (such as dlPFC, iFG, aIC, and iPL), and also to poor task performance (ie, choosing the best non-novelty The proportion of stimuli) is related.
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Eur Heart J: Be careful!
Time of Update: 2021-04-13
1093/eurheartj/ehab029/6184791" target="_blank" rel="noopener">Stress-associated neurobiological activity associates with the risk for and timing of subsequent Takotsubo syndrome , European Heart Journal, 2021; ehab029, https://doi.
1093/eurheartj/ehab029/6184791" target="_blank" rel="noopener">Stress-Associated neurobiological Activity Associates with The Risk for and Timing of Subsequent Takotsubo syndrome ,oup.
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JNNP: Neuroinflammation predicts disease progression in progressive supranuclear palsy
Time of Update: 2021-04-13
Whether these PET neuroinflammation and tau pathology biomarkers can predict the longitudinal clinical progression of PSP patients is unclear.
Therefore, this article investigates whether the in vivo baseline measurement of neuroinflammation ([11C]PK11195 PET) can predict the annual clinical progression rate of patients with PSP-Richardson syndrome.
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National Health Commission: 100% psychiatric hospitals set up psychological outpatient clinics, and 40% of general hospitals above the second level set up psychiatric (psychological) outpatient clinics
Time of Update: 2021-04-13
Including various forms of popular science education, providing psychological assistance services to key personnel affected by the epidemic, strengthening the construction of psychological crisis intervention teams, standardizing psychological assistance hotline services, improving the service mechanism for patients with severe mental disorders, and using depression and Alzheimer's as pilot special projects , And carry out other special projects in response to local problems that need to be solved or combined with local needs.
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JAHA: Gender and ethnic differences in the interval between arrival of patients with acute ischemic stroke in the hospital and CT examination
Time of Update: 2021-04-13
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart blood vessels published a research article on the disease areas authoritative magazine JAHA, the researchers aimed to assess the time interval from arrival at the hospital to accept the CT examination (DTCT) of ≤25 minutes of the patient's Florida Center for Stroke Registry (FSR) race And gender differences.
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Neurology: Compared with myocardial infarction, the risk of depression after cerebral infarction is higher
Time of Update: 2021-04-13
Blood vesselNaomi Mayman and others of Mount Sinai School of Medicine in the United States, based on the Medicare medical insurance database in the United States, explored American patients ≥65 years of age from July 1, 2016 to December 31, 2017, and compared ischemic stroke (IS) and Risks and predictors of new depression after myocardial infarction (MI).
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The first domestic epothilone tumor drug may be born: a new breast cancer class 1 drug "under approval"
Time of Update: 2021-04-13
A few days ago, the review status of utidelone (UTD1)'s new drug marketing application on the NMPA official website was updated to "under approval", or it is expected to be approved for the treatment of recurrent and metastatic advanced breast cancer in the near future .
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Using these drugs to treat Alzheimer's disease reduces the mortality rate by 27%
Time of Update: 2021-04-13
Researchers from the Karolinska Institute in Sweden published in the journal Neurology showed that for up to five years after diagnosis, the use of such drugs has consistently benefited from the cognitive aspect, and the mortality rate has also been reduced.
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Heart: Stroke incidence and predictive factors in patients with rheumatic heart disease
Time of Update: 2021-04-13
1136/heartjnl-2020-318054" target="_blank" rel="noopener">Incidence and predictors of stroke in patients with rheumatic heart disease .
1136/heartjnl-2020-318054" target="_blank" rel="noopener">Incidence and predictors of stroke in patients with rheumatic heart disease in this message
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JNNP: The effect of alemtuzumab on the efficacy and safety outcomes of patients with multiple sclerosis
Time of Update: 2021-04-13
This is particularly relevant ALEM, because its use is limited by recent medical authorities, only some patients pretreated and highly active, because it has a complex security, including infusion-related reactions (IAR), cerebral vascular complications And the potential development of secondary autoimmunity, even the last dose a few years after the injection.
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JNNP: MRI data-driven diagnosis algorithm for behavioral variant frontotemporal dementia
Time of Update: 2021-04-13
As expected, bvFTD subjects showed greater cognitive and functional impairment: the two groups had significant differences in MMSE, FTLD-CDR, MoCA, letter fluency Z score, and semantic fluency Z score (all p< 0.
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Is the 75-year-old Shaoxing old lady's brain "watered" into dementia?
Time of Update: 2021-04-13
"Your mind is flooded"We often use this sentence to diss peopleBut in fact, everyone has water in their headIt’s just that too much water will cause big problemsThere is a disease called "hydrocephalus"This is the caseHydrocephalus is not only common in patients with cerebral hemorrhage and traumatic brain injuryNormal people may also appear with ageFor example, a disease called "reversible dementia"Is caused by hydrocephalusShaoxing's 75-year-old grandmother Sun (a pseudonym) was hitToo much water in my headThe 75-year-old woman became "dementia"Mrs.
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Science Advances: Odontoblasts TRPC5 channel is a signal of tooth cold pain, which can be used as a new target for the treatment of toothache
Time of Update: 2021-04-13
The research team reported in Science Advances on March 26, 2021 that in mice and humans, tooth cells called odontoblasts contain cold-sensitive proteins that detect temperature drops.
Make you feel extraordinary pain!The research team tracked the location of the odontoblasts of TRPC5 between the pulp and dentin.
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Cerebral Cortex: New computational model reveals the mystery of cerebral cortex development
Time of Update: 2021-04-13
In terms of biological time, in the cortical development of humans, rats, mice, and macaques, the progenitor cell expansion process starts at about 30 days, 9.
Creative Destruction: A Basic Computational Model of Cortical Layer Formation Cerebral Cortex, bhab003, org/10.
