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Pixabay.
Pixabay.
One of the most typical characteristics of the nervous system of many vertebrates is the layered organization of different types of cells.
The computational model includes a gene regulatory network (GRN), which is instantiated in some precursor cells at the beginning of the simulation.
In this model, each cell follows the internal genotype rules while physically interacting with the local extracellular environment.
The first stage is the progenitor cell expansion stage, that is, the neural progenitor cell pool grows exponentially due to repeated cell divisions.
Figure 1.
Figure 1.
In this model, the proliferating cell possesses an internal clock realized by the intracellular material.
After the exponential proliferation phase (instantiated in cell state S1), progenitor cells still retain the potential for proliferation, but they may also have the potential to form various other types of cells.
In addition to the layer structure of the healthy cortex, the researchers also explored whether the model can capture the characteristics of certain neurodevelopmental disorders (Figure 2A-D).
Figure 2.
Studies on multiple cerebellar gyrus malformations have shown that the cortex becomes thinner when apoptosis is increased.
The study also found that specific defects in the dynamics of gene regulation that control apoptosis produce characteristics associated with this disease, emphasizing that impaired apoptosis may be a key factor in the origin of certain neurodevelopmental disorders.
Neuroinformatics professor at the University of Nottingham, senior author of the study Marcus Kaiser professor said : " a large part of the nerve cells died before birth, but it is unclear why these cells die after birth at such an early stage.
Considering the core role of apoptosis, it may be a fruitful direction for clinical research to change the behavior of apoptosis through medical intervention at the appropriate time of brain development.
org/10.
1093/cercor/bhab003">https://doi.
org/10.
1093/cercor/bhab003
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