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▎Editor's note from WuXi AppTec's content team: As the global population ages, the burden of diseases related to it is receiving increasing attention from society, among which neurodegenerative diseases are one of the focuses of attention.
Global burden of disease studies show that more than 1 billion people are currently affected by neurodegenerative diseases, and nearly 7 million people die from these diseases every year.
According to the prediction of the World Health Organization, by 2040, neurodegenerative diseases will replace cancer and become the second leading cause of death in humans.
Unfortunately, the research and development of new drugs for neurodegenerative diseases is an insurmountable danger.
Take Huntington’s disease, one of the four major neurodegenerative diseases, as an example.
Since last year alone, three promising therapies have failed in clinical trials.
The halberd sinks into the sand.
What can we learn from frustrated clinical trials? Can research on the treatment of Huntington's disease open a breakthrough for exploring other neurodegenerative diseases? Life is a journey forward with burdens, and for some people, this journey is even more rugged.
"What would you do if you could live for 100 years? What would you do if you had a 50% chance of living for only 6 months?" Kristen Power, who was only 16 years old, asked in the documentary Twitch.
Kristen's mother was diagnosed with Huntington's disease when she was 9 years old.
She saw her exquisite mother becoming clumsy, losing movement and coordination, and finally dying in pain but unable to do anything.
Not only that, 50% of hereditary diseases may also plant a bomb of uncertainty in her life.
Huntington's disease is an autosomal dominant genetic disease and one of the four major neurodegenerative diseases.
The incidence of less than one in ten thousand makes it the prefix of rare diseases, but in terms of pathogenesis and symptoms, Huntington’s disease is similar to Alzheimer’s disease, Parkinson’s disease and other well-known “senile diseases”.
Place.
There is currently no treatment to prevent or slow down the progression of the disease.
Since last year, a number of therapies for Huntington's disease have been under study, which has further clouded the research in this field.
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