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JAMA: The younger the onset of diabetes, the higher the risk of dementia
Time of Update: 2021-05-22
4001 In order to explore whether the younger the onset of diabetes is more closely related to the risk of dementia, the research team conducted a population-based study in the UK.
7 years, the younger age at onset of diabetes was significantly associated with a higher risk of subsequent dementia.
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Short-term air pollution exposure is linked to cognitive dysfunction in elderly men | "Nature-Aging" paper
Time of Update: 2021-05-22
A paper published in "Nature-Aging" Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study pointed out that short-term exposure (up to 28 days) is associated with high levels of air pollution.
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One article to clarify: 16 kinds of basal ganglia lesions
Time of Update: 2021-05-22
Imaging manifestations of bilateral symmetry T2/FLAIR hyperintensity: striatum (putamen> caudate nucleus> globus pallidus), periaqueductal gray matter, substantia nigra/hypothalamus, dorsal pons, and cerebellum.
Figure 12: Basal ganglia infarction image 2 Deep cerebral venous thrombosis Patients with deep venous thrombosis often have hypercoagulable factors, which are manifested as bilateral thalamus, internal capsule, basal ganglia and deep white matter involvement.
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Older women have slurred speech and unsteady walking. What are the reasons?
Time of Update: 2021-05-22
Brief medical history: Admitted to hospital for 2 days due to slurred speech and unstable walking.
October 23: PT 51 seconds, INR 5.
The cause of the blood coagulation abnormality and the lesions of the corpus callosum is not clear.
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NEJM: The overall survival is extended by 120%!
Time of Update: 2021-05-22
Recently, a research team led by Professor Gregory Friedman of the Department of Pediatrics at the University of Labama at Birmingham published a phase I clinical trial of HSV-1 G207 oncolytic virus in the treatment of recurrent high-grade glioma in children in the New England Journal of Medicine.
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The diagnosis and treatment of vascular cognitive impairment, a summary of the article
Time of Update: 2021-05-22
Cerebrovascular diseases represented by stroke, in addition to causing movement, sensation, vision and swallowing disorders, can also cause anxiety, depression, emotional incontinence, apathy, insomnia, fatigue, lack of willpower and other personality behavior changes, as well as decreased attention , Unresponsiveness, memory decline, aphasia, executive function decline and other vascular cognitive disorders.
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With the spear of the son and the shield of the attack, Nantah's Dong Lei team used apoptotic bodies to break through the blood-brain barrier and deliver therapeutic drugs
Time of Update: 2021-05-22
The study confirmed that nano-scale apoptotic bodies secreted by brain metastatic cancer cells can be used as a new type of drug delivery vehicle that can break through the blood-brain barrier.
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Sub-Journal of "Nature": Middle-aged people sleep less, old age is prone to dementia!
Time of Update: 2021-05-22
After adjusting for behavioral and health-related factors in the above model, the researchers only found that in the study population of 50 and 60 years old, compared with participants who slept for about 7 hours, the daily sleep time was less than or equal to 6 Hours are associated with a 22% and 37% increase in the risk of dementia.
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Important finding: Obesity can reduce blood supply to the brain, which may accelerate aging and dementia. Strengthening exercise can improve negative effects
Time of Update: 2021-05-22
The study revealed an important finding: Being overweight or obese greatly reduces blood flow in the brain, and decreased cerebral blood flow is an early mechanism of vascular dementia and Alzheimer's disease.
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Cell: Unintentionally inserting willows into shade!
Time of Update: 2021-05-22
On April 28, 2021, Lin Tian’s research team developed a 5-HT2AR ligand fluorescent receptor psychLight2 with millisecond time resolution on the basis of dLight1 in Cell magazine, and discovered a class of non-psychotic, potent antidepressant effects Compound AAZ-A-154.
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How to screen and evaluate elderly patients with hypertension and cognitive impairment, this consensus gives the answer
Time of Update: 2021-05-22
Therefore, this consensus recommends that, in addition to traditional blood pressure and cardiovascular risk stratification assessments, for elderly hypertensive patients, especially those with memory impairment, the cognitive function should be actively screened and comprehensive assessment of the elderly should be carried out in order to assess Elderly people carry out early, comprehensive and comprehensive intervention.
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The "blocker" of AD treatment (1): Damage to meningeal lymphatic vessels aggravates inflammation of microglia
Time of Update: 2021-05-22
This article reveals that cerebral lymphatic dysfunction aggravates the deposition of fibrinogen and neuro-inflammatory response, which hinders the transport of drugs to the brain parenchyma through the cerebrospinal fluid.
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Sci. Adv.|Xu Liang/Chen Ye/Huang Yulun collaborated to reveal the active chromatin map of glioblastoma
Time of Update: 2021-05-22
In addition, by analyzing cancer-specific enhancer signals, the study discovered and identified a series of transcription factors, long non-coding RNAs and drug targets (such as MNK2 and BRD4, etc.
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A real diary of dizziness from the dizziness doctor-is the end of the world really here?
Time of Update: 2021-05-22
In the afternoon, with the help of doctors and students in the department, I went to the vestibular function and hearing examination room of the outpatient clinic to complete the cold and heat test, hearing and VEMP examination together.
Timely vestibular rehabilitation can help patients recover as soon as possible in balance function.
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Rare case: 6 years after a Korean woman was diagnosed with progressive freezing, was she diagnosed with neuromyelitis optica again?
Time of Update: 2021-05-22
Amyotrophic Crest Lateral Sclerosis (ALS) is a fatal neurodegenerative disease in which patients show loss of motor neurons.
Therefore, the report of this case suggests that in clinical diagnosis, if ALS patients have AQP4 antibodies, it is recommended to follow up the risk of NMOSD carefully.
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April Neurology Guidelines and Consensus, one article is included in the bag|Guide Consensus
Time of Update: 2021-05-22
This article summarizes the domestic and international neurological disease-related guidelines and consensus issued in April 2021 for everyone to read and download. Yimaitong compiles and organizes,
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Express | Better than the approved DMD therapy, the new generation of oligonucleotide therapy Phase 2 clinical results are positive
Time of Update: 2021-05-22
▎Editor of WuXi AppTec's content team On May 3, 2021, Sarepta Therapeutics announced its new generation antisense oligonucleotide therapy SRP-5051 for the treatment of patients with Duchenne muscular dystrophy (DMD).
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NEUROBIOL AGING: Obesity is related to decreased cerebral blood flow, but exercise can be improved!
Time of Update: 2021-05-22
Recently, a study published in the journal Neurobiology of Aging showed that being overweight or obese can greatly reduce blood flow in the brain, but increasing physical exercise can positively change or even offset this decrease in cerebral blood flow.
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JAHA: The relationship between air particulate pollution and the risk of cardiovascular events in adults with stroke or acute myocardial infarction
Time of Update: 2021-05-21
StrokeThe Cox proportional hazards model estimated the risks of stroke, acute myocardial infarction, and cardiovascular death associated with PM2.
Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction .
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What do you know about autosomal recessive cerebellar ataxia?
Time of Update: 2021-05-21
Typical ataxia manifestations are as follows: Ataxia (appendicular or axial) of the limbs or trunk, Dysmetria, poor coordination, Dyssynergia, rotation dyskinesia, Dysdiadochokinesia, rebound phenomenon, Rebound Phenomenon, Dysarthria, Tremor, postural and gait instability, Titubation and increased postural sway tension reduction Hypotonia weakness Asthenia nystagmus Nystagmus and other eye movement disorders autosomal recessive inherited cerebellar ataxia (ARCA) is a complex, heterogeneous and disabling neurogenetic degeneration Diseases are more common in children and early adult patients.
