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Nature sub-news: Don't rush to get rid of plaques! Plaque in Alzheimer's disease may be protective
Time of Update: 2021-05-22
However, according to this new study, it is actually microglia that form dense plaques from diffuse amyloid beta fibrils as part of their cell clearance.
Using an animal model, researchers were able to experimentally prove for the first time that microglia with TAM receptors ingest amyloid plaques through eat-me signaling and Gas6.
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Sci. Adv.|Xu Liang/Chen Ye/Huang Yulun collaborated to reveal the active chromatin map of glioblastoma
Time of Update: 2021-05-22
In addition, by analyzing cancer-specific enhancer signals, the study discovered and identified a series of transcription factors, long non-coding RNAs and drug targets (such as MNK2 and BRD4, etc.
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Cell: Unintentionally inserting willows into shade!
Time of Update: 2021-05-22
On April 28, 2021, Lin Tian’s research team developed a 5-HT2AR ligand fluorescent receptor psychLight2 with millisecond time resolution on the basis of dLight1 in Cell magazine, and discovered a class of non-psychotic, potent antidepressant effects Compound AAZ-A-154.
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NEUROBIOL AGING: Obesity is related to decreased cerebral blood flow, but exercise can be improved!
Time of Update: 2021-05-22
Recently, a study published in the journal Neurobiology of Aging showed that being overweight or obese can greatly reduce blood flow in the brain, but increasing physical exercise can positively change or even offset this decrease in cerebral blood flow.
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The "blocker" of AD treatment (1): Damage to meningeal lymphatic vessels aggravates inflammation of microglia
Time of Update: 2021-05-22
This article reveals that cerebral lymphatic dysfunction aggravates the deposition of fibrinogen and neuro-inflammatory response, which hinders the transport of drugs to the brain parenchyma through the cerebrospinal fluid.
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April Neurology Guidelines and Consensus, one article is included in the bag|Guide Consensus
Time of Update: 2021-05-22
This article summarizes the domestic and international neurological disease-related guidelines and consensus issued in April 2021 for everyone to read and download. Yimaitong compiles and organizes,
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NEJM: The overall survival is extended by 120%!
Time of Update: 2021-05-22
Recently, a research team led by Professor Gregory Friedman of the Department of Pediatrics at the University of Labama at Birmingham published a phase I clinical trial of HSV-1 G207 oncolytic virus in the treatment of recurrent high-grade glioma in children in the New England Journal of Medicine.
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JAMA: The younger the onset of diabetes, the higher the risk of dementia
Time of Update: 2021-05-22
4001 In order to explore whether the younger the onset of diabetes is more closely related to the risk of dementia, the research team conducted a population-based study in the UK.
7 years, the younger age at onset of diabetes was significantly associated with a higher risk of subsequent dementia.
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A real diary of dizziness from the dizziness doctor-is the end of the world really here?
Time of Update: 2021-05-22
In the afternoon, with the help of doctors and students in the department, I went to the vestibular function and hearing examination room of the outpatient clinic to complete the cold and heat test, hearing and VEMP examination together.
Timely vestibular rehabilitation can help patients recover as soon as possible in balance function.
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Rare case: 6 years after a Korean woman was diagnosed with progressive freezing, was she diagnosed with neuromyelitis optica again?
Time of Update: 2021-05-22
Amyotrophic Crest Lateral Sclerosis (ALS) is a fatal neurodegenerative disease in which patients show loss of motor neurons.
Therefore, the report of this case suggests that in clinical diagnosis, if ALS patients have AQP4 antibodies, it is recommended to follow up the risk of NMOSD carefully.
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The first child with dual route gene therapy!
Time of Update: 2021-05-22
S. Authority The newspaper USA TODAY reported a story about gene therapy and a child with Sandhoff's disease-Now, instead of certain death, she faces an uncertain future.
Alissa was a gene therapy patient who received both routes of administration at the same time.
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Short-term air pollution exposure is linked to cognitive dysfunction in elderly men | "Nature-Aging" paper
Time of Update: 2021-05-22
A paper published in "Nature-Aging" Short-term air pollution, cognitive performance and nonsteroidal anti-inflammatory drug use in the Veterans Affairs Normative Aging Study pointed out that short-term exposure (up to 28 days) is associated with high levels of air pollution.
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The diagnosis and treatment of vascular cognitive impairment, a summary of the article
Time of Update: 2021-05-22
Cerebrovascular diseases represented by stroke, in addition to causing movement, sensation, vision and swallowing disorders, can also cause anxiety, depression, emotional incontinence, apathy, insomnia, fatigue, lack of willpower and other personality behavior changes, as well as decreased attention , Unresponsiveness, memory decline, aphasia, executive function decline and other vascular cognitive disorders.
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Sub-Journal of "Nature": Middle-aged people sleep less, old age is prone to dementia!
Time of Update: 2021-05-22
After adjusting for behavioral and health-related factors in the above model, the researchers only found that in the study population of 50 and 60 years old, compared with participants who slept for about 7 hours, the daily sleep time was less than or equal to 6 Hours are associated with a 22% and 37% increase in the risk of dementia.
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With the spear of the son and the shield of the attack, Nantah's Dong Lei team used apoptotic bodies to break through the blood-brain barrier and deliver therapeutic drugs
Time of Update: 2021-05-22
The study confirmed that nano-scale apoptotic bodies secreted by brain metastatic cancer cells can be used as a new type of drug delivery vehicle that can break through the blood-brain barrier.
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Important finding: Obesity can reduce blood supply to the brain, which may accelerate aging and dementia. Strengthening exercise can improve negative effects
Time of Update: 2021-05-22
The study revealed an important finding: Being overweight or obese greatly reduces blood flow in the brain, and decreased cerebral blood flow is an early mechanism of vascular dementia and Alzheimer's disease.
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Express | Better than the approved DMD therapy, the new generation of oligonucleotide therapy Phase 2 clinical results are positive
Time of Update: 2021-05-22
▎Editor of WuXi AppTec's content team On May 3, 2021, Sarepta Therapeutics announced its new generation antisense oligonucleotide therapy SRP-5051 for the treatment of patients with Duchenne muscular dystrophy (DMD).
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Milestone in the treatment of muscular dystrophy: single-base editing allows muscle stem cells to develop into muscle fibers
Time of Update: 2021-05-22
The research team took a sample of muscle tissue from a 10-year-old patient and isolated muscle stem cells, then cultured these stem cells in vitro, and used single-base editing (Base Editing) technology to replace the base pairs at the mutation site.
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JAHA: The relationship between air particulate pollution and the risk of cardiovascular events in adults with stroke or acute myocardial infarction
Time of Update: 2021-05-21
StrokeThe Cox proportional hazards model estimated the risks of stroke, acute myocardial infarction, and cardiovascular death associated with PM2.
Particulate Air Pollution and Risk of Cardiovascular Events Among Adults With a History of Stroke or Acute Myocardial Infarction .
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The correlation between new antiepileptic drugs and drug-induced liver injury: a real-world study from the FDA's adverse event reporting system
Time of Update: 2021-05-21
2% were "serious" reactions: death (262) disability (26) hospitalization (1,232) life-threatening reactions (248) congenital abnormalities or birth defects (4) And other serious reactions (1,475) ➤ Anti-epileptic drugs such as carbamazepine, phenobarbital, oxcarbazepine, phenytoin, valproic acid, lamotrigine, clobazan, levetiracetam, and diazepam, The incidence of drug-induced liver injury is higher than that of non-antiepileptic drugs (see Table 1).