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Diabetes is a metabolic disease characterized by chronically elevated blood sugar levels, mainly including type 1 diabetes and type 2 diabetes, and its prevalence and incidence have been high.
Due to an aging population, increasing obesity, lack of exercise, and energy-intensive diets, the prevalence of type 2 diabetes is rising.
More than 90% of diabetic patients suffer from type 2 diabetes.
Current studies have shown that diabetes is associated with higher cardiovascular disease morbidity and mortality.
Large-scale multi-cohort meta-analysis has shown that the risk ratio between diabetes and dementia is between 1.
43 and 1.
62.
But the main limitation of its research is that it cannot test the importance of age at onset of diabetes to dementia.
On April 27, 2021, the Archana Singh-Manoux team of the University of Paris, France, published the research results in the Journal of the American Medical Association, entitled "Association Between Age at Diabetes Onset and Subsequent Risk of Dementia", which studied the age at onset of diabetes and dementia.
The relevance of risks.
DOI: 10.
1001/jama.
2021.
4001 In order to explore whether the younger the onset of diabetes is more closely related to the risk of dementia, the research team conducted a population-based study in the UK.
This study is called the Whitehall II study.
The ongoing cohort study was established from 1985 to 1988, and the subjects were 10,308 people (6895 men and 3413 women, aged 35-55 years) in London.
Starting from the baseline, follow-up clinical examinations will be conducted approximately every 4-5 years, and each cycle needs to be completed in 2 years.
Data will be collected continuously during the 2020-2021 cycle and linked to the electronic health record. The relevant recorded data is updated once a year until March 31, 2019.
Type 2 diabetes is defined as a fasting blood glucose level greater than or equal to 126 mg/dL at the time of clinical examination, a doctor's diagnosis of type 2 diabetes, use of diabetes medications, or diabetes hospitalization records from 1985 to 2019.
The relationship between type 2 diabetes and the incidence of dementia and age at onset of diabetes.
67.
3% of the 10,095 participants were men.
The average follow-up was 31.
7 years.
The research group recorded 1,710 diabetic patients and 639 dementia patients.
Among participants without diabetes at the age of 70, the rate of dementia per 1,000 person-years was 8.
9; among participants who had onset 5 years ago, the rate of dementia per 1,000 person-years was 10.
0; those who had onset between 6 and 10 years ago Among the participants, the dementia rate per 1,000 person-years was 13.
0; among the participants who had onset 10 years ago, the dementia rate per 1,000 person-years was 18.
3.
Correlation between diabetes risk scores at 55, 60, 65, and 70 years and the incidence of dementia In a multivariate adjusted analysis, compared with participants without diabetes at 70, the risk of dementia in diabetic patients 10 years ago was higher The risk ratio of dementia in diabetic patients 6-10 years ago was 1.
49, and the risk ratio of dementia in patients with diabetes onset for less than 5 years was 1.
11; the linear trend test showed that there was a graded association between the age at onset of type 2 diabetes and dementia .
In an adjusted analysis of sociodemographic factors, health behaviors, and health-related measures, at the age of 70, the risk ratio of dementia is 1.
24 for every 5 years younger than the age of onset of type 2 diabetes.
The role of cardiovascular comorbidities in the association between diabetes and dementia, the study finally mentioned: the current research does not have strong evidence that there is a connection between pre-diabetes and dementia.
Fasting blood glucose within the normal range may not have an adverse effect on brain function.
There is only a slight correlation between fasting blood glucose in non-diabetics and the risk of vascular disease.
A certain threshold of high glucose levels may be a necessary condition for brain damage induced by hyperglycemia, so it is important to consider whether vascular comorbidities are related to the onset of dementia in diabetic patients.
In summary, in this longitudinal cohort study with a median follow-up of 31.
7 years, the younger age at onset of diabetes was significantly associated with a higher risk of subsequent dementia.
End reference materials: [1]https://jamanetwork.
com/journals/jama/article-abstract/2779197
Due to an aging population, increasing obesity, lack of exercise, and energy-intensive diets, the prevalence of type 2 diabetes is rising.
More than 90% of diabetic patients suffer from type 2 diabetes.
Current studies have shown that diabetes is associated with higher cardiovascular disease morbidity and mortality.
Large-scale multi-cohort meta-analysis has shown that the risk ratio between diabetes and dementia is between 1.
43 and 1.
62.
But the main limitation of its research is that it cannot test the importance of age at onset of diabetes to dementia.
On April 27, 2021, the Archana Singh-Manoux team of the University of Paris, France, published the research results in the Journal of the American Medical Association, entitled "Association Between Age at Diabetes Onset and Subsequent Risk of Dementia", which studied the age at onset of diabetes and dementia.
The relevance of risks.
DOI: 10.
1001/jama.
2021.
4001 In order to explore whether the younger the onset of diabetes is more closely related to the risk of dementia, the research team conducted a population-based study in the UK.
This study is called the Whitehall II study.
The ongoing cohort study was established from 1985 to 1988, and the subjects were 10,308 people (6895 men and 3413 women, aged 35-55 years) in London.
Starting from the baseline, follow-up clinical examinations will be conducted approximately every 4-5 years, and each cycle needs to be completed in 2 years.
Data will be collected continuously during the 2020-2021 cycle and linked to the electronic health record. The relevant recorded data is updated once a year until March 31, 2019.
Type 2 diabetes is defined as a fasting blood glucose level greater than or equal to 126 mg/dL at the time of clinical examination, a doctor's diagnosis of type 2 diabetes, use of diabetes medications, or diabetes hospitalization records from 1985 to 2019.
The relationship between type 2 diabetes and the incidence of dementia and age at onset of diabetes.
67.
3% of the 10,095 participants were men.
The average follow-up was 31.
7 years.
The research group recorded 1,710 diabetic patients and 639 dementia patients.
Among participants without diabetes at the age of 70, the rate of dementia per 1,000 person-years was 8.
9; among participants who had onset 5 years ago, the rate of dementia per 1,000 person-years was 10.
0; those who had onset between 6 and 10 years ago Among the participants, the dementia rate per 1,000 person-years was 13.
0; among the participants who had onset 10 years ago, the dementia rate per 1,000 person-years was 18.
3.
Correlation between diabetes risk scores at 55, 60, 65, and 70 years and the incidence of dementia In a multivariate adjusted analysis, compared with participants without diabetes at 70, the risk of dementia in diabetic patients 10 years ago was higher The risk ratio of dementia in diabetic patients 6-10 years ago was 1.
49, and the risk ratio of dementia in patients with diabetes onset for less than 5 years was 1.
11; the linear trend test showed that there was a graded association between the age at onset of type 2 diabetes and dementia .
In an adjusted analysis of sociodemographic factors, health behaviors, and health-related measures, at the age of 70, the risk ratio of dementia is 1.
24 for every 5 years younger than the age of onset of type 2 diabetes.
The role of cardiovascular comorbidities in the association between diabetes and dementia, the study finally mentioned: the current research does not have strong evidence that there is a connection between pre-diabetes and dementia.
Fasting blood glucose within the normal range may not have an adverse effect on brain function.
There is only a slight correlation between fasting blood glucose in non-diabetics and the risk of vascular disease.
A certain threshold of high glucose levels may be a necessary condition for brain damage induced by hyperglycemia, so it is important to consider whether vascular comorbidities are related to the onset of dementia in diabetic patients.
In summary, in this longitudinal cohort study with a median follow-up of 31.
7 years, the younger age at onset of diabetes was significantly associated with a higher risk of subsequent dementia.
End reference materials: [1]https://jamanetwork.
com/journals/jama/article-abstract/2779197
