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Lancet Sub-Journal: What is the probability of recurrence of stroke after cerebral hemorrhage?
Time of Update: 2021-06-10
Comparing population-based research data with data from patients who did not receive antiplatelet therapy when restarting, there is no evidence that there is a difference in recurrence rates of cerebral hemorrhage or ischemic stroke.
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Aging Cell: Inhibition of longevity gene SIRT2 can treat neuropathy
Time of Update: 2021-06-10
SIRT2 heredity Inhibition can save axonal CMT neuropathy caused by GARS and prolong life .
Inherited inhibition of SIRT2 can save axonal CMT neuropathy caused by GARS and prolong life.
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Brain: This group of plasma markers may predict future brain atrophy and dementia
Time of Update: 2021-06-10
Plasma P-tau217 and NfL levels independently predict the changes of longitudinal brain atrophy in non-dementia individuals.
Plasma P-tau217 and NfL levels independently predict the changes of longitudinal brain atrophy in non-dementia individuals.
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Nat Genet: A transcriptional map of microglia related to the central nervous system
Time of Update: 2021-06-10
In this study, the researchers aimed to conduct a population-scale study of microglia to understand how age, gender, pathology, cortical anatomy, and common germline genetic variations affect the transcriptome of microglia.
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Academician Luo Liqun discovered a new mechanism of the complex network connection of brain neurons: molecular mutual repulsion
Time of Update: 2021-06-10
The study found that the cell surface in the inner and outer hippocampal loops in mice The complementary expression of molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) respectively guide the precise loop assembly of CA1 to subiculum connection.
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Nat Commun: Outcomes after acute ischemic stroke are related to gender
Time of Update: 2021-06-10
Therefore, the results of this study indicate that there are gender-specific brain function asymmetries in the population , which may be important for future research on gender-stratified management methods for acute ischemic stroke .
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Stroke: The relationship between menopausal age and the risk of ischemic and hemorrhagic stroke
Time of Update: 2021-06-10
StrokeRecently, the heart blood vessels published a research article on the disease areas authoritative journal Stroke, researchers to investigate (natural and surgical) whether age at menopause is a risk factor for women of all types, ischemic and hemorrhagic stroke.
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IEEE trans: Use wearable inertial sensors to assess the level of upper limb injury in stroke survivors
Time of Update: 2021-06-10
This study aims to estimate the upper limb injury of stroke survivors by introducing a method based on a single, minimal-burden motor task and two wearable inertial sensors (one worn on the wrist of the stroke-affected limb and the other on the sternum) , Thereby minimizing the burden of instruments and tasks for wearable sensing evaluation.
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Neurology: With these characteristics, the risk from mild cognitive impairment to dementia is greatly increased!
Time of Update: 2021-06-10
However, it is still unclear whether MCI (rapid eye movement sleep behavior disorder [RBD], Parkinson's disease, complex visual hallucinations and cognitive fluctuations) with the core clinical features of DLB has a worse clinical prognosis than MCI-AD, and the onset of dementia Faster.
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Brain: DPP4 inhibitors provide long-term benefits for patients with diabetic Parkinson's disease
Time of Update: 2021-06-10
So, does the treatment of DPP4 inhibitors have a beneficial effect on the substantia nigra dopamine and longitudinal exercise performance of diabetic patients with PD?
In addition, PD diabetic patients receiving DPP4 inhibitors had higher dopamine transporter availability in the posterior putamen than non-diabetic Parkinson's disease patients (1.
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ASCO-2021 Express: Recurrent glioblastoma, Nivolumab combined with standard bevacizumab can benefit older patients
Time of Update: 2021-06-10
Therefore, the combination of anti-PD1 and anti-vascular endothelial growth factor may be a promising treatment for rGBM.
Therefore, the combination of anti-PD1 and anti-vascular endothelial growth factor may be a promising treatment for rGBM.
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Progress in Metz Neurology (Issue 003)
Time of Update: 2021-06-10
New research reveals: Nervous system may replace antibiotics to inhibit bacterial infectionsFor details, please refer to: Plos Pathogens: Magical!
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ASCO-2021 Express: Spectral MRI can guide glioblastoma radiotherapy, safe and effective
Time of Update: 2021-06-10
The inclusion criteria include newly diagnosed GBM patients, aged ≥18 years, and the tumor site can be fully imaged by sMRI.
Under the guidance of sMRI, the dose-escalation RT reached 75Gy, which seems feasible and safe for newly diagnosed GBMs patients.
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Nat Commun: Infant gut microbial composition is related to non-social fear behavior
Time of Update: 2021-06-10
Recently, in a pilot study of 34 infants, researchers found that the composition of the gut microbiome (Weighted Unifrac; lower abundance of Bacteroides, increased abundance of Veillonella, Dialister, and Clostridiales) at the age of 1 The increase in fear behavior in the social fear paradigm is clearly related .
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The first domestic hormone replacement therapy for the treatment of hypoparathyroidism was approved for Phase III...
Time of Update: 2021-06-08
The primary endpoint includes evaluating the safety, tolerability and efficacy of once daily subcutaneous injection of TransCon™ parathyroid hormone in the treatment of adult HP The randomized, double-blind, placebo-controlled, parallel-designed, multi-center phase III clinical trial aimed at bringing the subjects’ blood calcium to normal while discontinuing conventional treatments.
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Research and develop new fluorescent probes to achieve accurate detection of dynamic changes of serotonin in vivo
Time of Update: 2021-06-08
On April 5, 2021, the research group of Professor Li Yulong from the School of Life Sciences of Peking University published a research paper entitled "A genetically encoded sensor for measuring serotonin dynamics" online in Nature Neuroscience, reporting a new genetically encoded 5-HT fluorescent probe Development and its application in a variety of model organisms.
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Nurtec Prevents and Treats Migraine
Time of Update: 2021-06-08
Recently, the US FDA announced the approval of an oral CGRP inhibitor Nurtec ODT (Rimegepant, 75mg) as an extended indication for the preventive treatment of paroxysmal migraine.
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Cell Journal: What determines your appetite, is it your belly?
Time of Update: 2021-06-08
Recently, a new study published in a sub-Journal of Cell shows that the intestinal-brain communication of different sensory neurons controls eating and glucose metabolism in different ways .
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The first oral new drug for overactive bladder (OAB) in the past 10 years!
Time of Update: 2021-06-08
Gemtesa is an oral, once-a-day tablet, each containing 75mg vibegron, which is a small molecule β3 adrenergic receptor agonist, which relaxes the detrusor muscle and enables the bladder to hold more urine, thereby Reduce the annoying symptoms of OAB.
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Neurobiology of Stress: Stress-induced changes in microglia-related synaptic circuits in the dorsal medial prefrontal cortex
Time of Update: 2021-06-08
In vivo two-photon imaging further revealed that stress increases the elimination of dmPFC dendritic spines , especially mushroom-shaped, without affecting the formation of spinous processes.
