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ASCO-2021 Express: Spectral MRI can guide glioblastoma radiotherapy, safe and effective

 Last Update: 2021-06-10
 Source: Internet
 Author: User

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Glioblastoma (GBM) is the most common adult primary malignant brain tumor.

Magnetic resonance spectroscopy (MRS) measures the levels of specific metabolites in the brain, including choline (Cho) and N-acetylaspartic acid (NAA).

That is, spectral MRI (sMRI) is used to guide the feasibility and safety of the RT dose upgrade of newly diagnosed GBMs.

The Cho/NAA ratio was normalized to the normal white matter (NAWM) on the contralateral side.

GTV3 (=CTV3, sMRI definition) is produced by the combination of CE residual tumor and Cho/NAA≥2 times NAWM.

Planned target areas (PTVs) are created by applying 3 mm edges around CTVs.

A total of 30 patients were eligible and received study treatment.

The median follow-up time of excluded patients was 21.

Among the 7 patients 9 months after treatment, most can be attributed to TMZ (thrombocytopenia × 4, platelet/neutropenia × 1, transaminase × 1), and only one case (headache/fatigue × 1) It may be attributed to RT.

Hui-Kuo George Shu, Eric Albert Mellon, Lawrence Kleinberg, Saumya S Gurbani, Karthik K Ramesh, Mohammed Goryawala, Sulaiman Ahmed Sheriff, Vicki Huang, Peter B Barker, Andrew Maudsley, Eduard Schreibmann, Brent D Weinberg, Hyunsuk Shim; Department of Radiation Oncology, Winship Cancer Institute of Emory University, Atlanta, GA; University of Miami Miller School of Medicine, Miami, FL; Johns Hopkins University School of Medicine, Baltimore, MD; Emory University School of Medicine, Atlanta, GA; Emory University, Winship Cancer Institute, Atlanta, GA

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