Progress in Metz Neurology (Issue 003)

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Editor's note: Metz Medicine will regularly summarize the latest developments in the neurological field.

Editor's note: Metz Medicine will regularly summarize the latest developments in the neurological field.

For details in the previous issue: Progress in Metz Neurology (Issue 002)

1.

1.

However, whether the microstructure of cortical NDI is related to the pathology of AD before the onset of cognitive impairment remains to be determined.

For details, please refer to: Alzheimers Dementia: Pathological protein level in cerebrospinal fluid, which can reflect the density of cortical neurons

Alzheimers Dementia: Pathological protein levels in cerebrospinal fluid, which can reflect the density of cortical neurons

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2.

Researchers have discovered new glioblastoma activating proteins, in which PTPN11 and PLCG1 have more prominent functions.

Researchers have discovered new glioblastoma activating proteins, in which PTPN11 and PLCG1 have more prominent functions.

For details, refer to: Cancer cell: The largest glioblastoma "map" to date, Ding Lituan reveals the biological map that plays a key role in fatal brain tumors Cancer cell: The largest glioblastoma "map" to date, Ding Lituan reveals the fatal Biographies that play a key role in brain tumors

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3.

Small vessel disease and related risks of stroke and dementia are related to aging and hypertension, but it is unclear whether fluctuating or stable blood pressure (BP) is an important factor in the development of macroscopic hyperintensity and microscopic white matter damage.

The researchers determined the linear correlation between neuroimaging markers (white matter hyperintensity [WMH] volume and diffusion imaging index) and mean arterial pressure and pulse pressure (PP), including uncorrected and corrected age, gender, and cardiovascular Risk factors, antihypertensive drugs, blood pressure sources and assessment centers.

For details, please refer to: Hypertension: White matter hyperintensity and microstructure injury blood pressure determining parameter Hypertension: White matter hyperintensity and microstructure injury blood pressure determining parameter

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4.

Recently, research scholars from Virginia Tech published in the Journal of Cognitive Neuroscience found that early education has a lasting effect on brain structure.

The study began in 1970, with children mainly  (98%)  coming from African-American infants from very low  SES  (low-income and maternal education) families.
There were 78 study participants in the study (42 intervention group and 36 control group).
The intervention is a comprehensive development of appropriate cognitive and language enrichment plans to create a positive and responsive childcare environment for the experimental group of children, 5 days a week (6-8 hours), 50 weeks a year.
The study began in 1970, with children mainly  (98%)  coming from African-American infants from very low  SES  (low income and maternal education) families.
There were 78 study participants in the study (42 intervention group and 36 control group).
The intervention is a comprehensive development of appropriate cognitive and language enrichment plans to create a positive and responsive childcare environment for the experimental group of children, 5 days a week (6-8 hours), 50 weeks a year.
Children mainly  (98%)  come from African-American infants from very low  SES  (low income and maternal education) families.
There were 78 study participants in the study (42 intervention group and 36 control group).
The intervention is a comprehensive development of appropriate cognitive and language enrichment plans to create a positive and responsive childcare environment for the experimental group of children, 5 days a week (6-8 hours), 50 weeks a year.

In the decades that followed, participants blindly assessed their functions in all important areas of life, including cognitive, educational, socio-emotional, professional, economic, and health outcomes.
Cognition is assessed through IQ and academic performance tests of reading and math skills.
In follow-up examinations, 47 study participants were subjected to MRI scans of the brain structures .
Analysis of the scan results showed that the participants in the early education intervention group increased their entire brain volume , including the cortex .
And the intervention treatment of the male brain is significantly greater than that of the female .

In follow-up examinations, 47 study participants were subjected to MRI scans of the brain structures .
Scan analysis showed, early education early education intervention intervention group of the group of participants participants whole brain whole brain volume volume increased to increase , including skin , including skin .
.
And and the male brain of the male brain intervention results significantly larger than females therapeutic intervention results significantly larger than females .
.

For details, please refer to: J Cogn Neurosci: 50 years of observational research shows that early active learning in young children can affect the adult brain

For details, refer to: J Cogn Neurosci: 50 years of observational studies show that early childhood active learning can affect the adult brain J Cogn Neurosci: 50 years of observational studies show that early childhood active learning can affect the adult brain

5.
Neurology: The effect of neurofeedback promotion on gait and balance recovery after stroke

5.
Neurology: The effect of neurofeedback promotion on gait and balance recovery after stroke 5.

Experts from the Neuroengineering Department of the Center for Global Medical Engineering and Informatics, Osaka University, Japan conducted a double-center, double-blind, randomized controlled trial involving 54 Japanese patients, using a 3-meter timed start (TUG) test.
The researchers included patients with mild to moderate gait disorder caused by subcortical stroke, and used fNIRS-NFB for 6 SMA neurofeedback facilitation treatments in gait and balance-related motor imaging.

The results showed that the improvement of the intervention group in the TUG test was greater than that of the control group, and the recovery rate was 7.
89%.
That is the adjustment of covariates, differences still exist.
At the same time, only the intervention group showed a significant increase in image-related SMA activation, and the static connection between the SMA and the lateral premotor zone was enhanced.
Therefore, the use of fNIRS neurofeedback may enhance gait and balance recovery after stroke by adjusting SMA and its related networks.

The results showed that the improvement of the intervention group in the TUG test was greater than that of the control group, and the recovery rate was 7.
89%.
That is the adjustment of covariates, differences still exist.
The improvement of the intervention group in the TUG test was greater than that of the control group, and the recovery rate was 7.
89%.
That is , the improvement of the intervention group in the TUG test was greater than that of the control group, and the recovery rate was 7.
89%.
That is , the improvement of the intervention group in the TUG test was greater than that of the control group, and the recovery rate was 7.
89%.
That is, at the same time, only the intervention group showed a significant increase in image-related SMA activation, and the static state connection between the SMA and the lateral premotor area was enhanced.
Therefore, the use of fNIRS neurofeedback may enhance gait and balance recovery after stroke by adjusting SMA and its related networks.
At the same time, only the intervention group showed a significant increase in image-related SMA activation, and the static connection between the SMA and the lateral premotor zone was enhanced.
Therefore, the use of fNIRS neurofeedback may enhance gait and balance recovery after stroke by adjusting SMA and its related networks.

For details, please refer to: Neurology: The effect of neurofeedback promotion on gait and balance recovery after stroke

Details Reference: Neurology: Neurofeedback promoting effect on post-stroke recovery of gait and balance details Reference: Neurology: Neurofeedback promoting effect on post-stroke recovery of gait and balance details Reference: Neurology: Neurofeedback promote and gait after stroke The effect of balance recovery Neurology: The effect of neurofeedback promotion on gait and balance recovery after stroke

6.
Nature: Neuronal activity promotes tumor growth, which is originally related to it

6, Nature: Neuronal activity promotes tumor growth, which is originally related to it 6, 6,6,

On May 26, 2021, Michelle Monje of the Department of Neurology and Neuroscience of Stanford University and David H.
Gutmann of the Department of Neurology of Washington University School of Medicine published an article in the journal Nature revealing that neurofibromatosis type 1 gene mutations promote neural activity dependence Optic neuroma growth.

They injected optogenetic virus into RGC of Nf1-OPG transgenic mice, and assessed the tumor growth rate at 12 weeks after activating RGC at 6 weeks of age.
The results showed that the volume of the optic nerve became larger after light-activated RGC, and the proliferation of glioma cells increased significantly, which indicated that the nerve activity of RGC promoted the growth of optic neuroma.
After knocking out NLGN3, the tumor growth of Nf1-OPG transgenic mice seemed to be paused: the volume of the optic nerve was no different from normal, and the proliferation of tumor cells was significantly reduced.
This indicates that NLGN3 is involved in the tumor development process of poorly differentiated optic neuroma.

This is an exciting study.
This article uses a tumor gene model mouse to reveal the discovery that light-induced neuronal activity not only promotes tumor growth, but is also responsible for the tumor initiation process.

This article uses a tumor gene model mouse to reveal the discovery that light-induced neuronal activity not only promotes tumor growth, but is also responsible for the tumor initiation process.

For details, please refer to: Nature: Neuronal activity promotes tumor growth, which is originally related to it

For details, please refer to: Nature: Neuron activity promotes tumor growth, and it is related to it.
For more details: Nature: Neuron activity promotes tumor growth, which is related to it.
For details, refer to: Nature: Neuron activity promotes tumor growth.
About Nature: Neuronal activity promotes tumor growth, which is actually related to it

7.
Plos Pathogens: Magical! New research reveals: Nervous system may replace antibiotics to inhibit bacterial infections

7, 7, 7,

Recently, the journal Plos Pathogens published a study revealing a new mechanism by which the nervous system senses local bacterial infections and rapidly activates the immune response.
In the traditional impression, the nervous system is only the receiver and transmitter of information, but it is not so "simple".
The new study found that when encountering bacterial invasion, the human nervous tissue will activate the "sensing and alerting" system, which can quickly deliver early warning information to various tissues and organs within a few hours of infection.

In the early stages of bacterial infections, the nervous system plays an indispensable role as the emissary of immune surveillance and immune regulatory response.
This study fully highlights the importance of the nervous system in the early stages of bacterial infection.
In the post-antibiotic era, regulating bacterial infections through the nervous system may become a new way to detect or control infections.

The importance of the nervous system in the early stages of bacterial infections.
In the post-antibiotic era, regulating bacterial infections through the nervous system may become a new way to detect or control infections.

For details, please refer to: Plos Pathogens: Magical! New research reveals: Nervous system may replace antibiotics to inhibit bacterial infections

For details, please refer to: Plos Pathogens: Magical! New research reveals: The nervous system may replace antibiotics to inhibit bacterial infections.
For more details, please refer to: Plos Pathogens: Magic! New research reveals: The nervous system may replace antibiotics to inhibit bacterial infections.
For more details, please refer to: Plos Pathogens: Magic! New research reveals: The nervous system may replace antibiotics to inhibit bacterial infections.
Plos Pathogens: Miracle! New study reveals: the nervous system or alternative antibiotics inhibit bacterial infectionin this message