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    Home > Active Ingredient News > Study of Nervous System > Neurobiology of Stress: Stress-induced changes in microglia-related synaptic circuits in the dorsal medial prefrontal cortex

    Neurobiology of Stress: Stress-induced changes in microglia-related synaptic circuits in the dorsal medial prefrontal cortex

    • Last Update: 2021-06-08
    • Source: Internet
    • Author: User
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    Stress is very common in modern life.


    Stress is very common in modern life.


     

    7d restraint stress (RS) reduced the branching and increased the process dynamics of microglia in dmPFC.


    7d restraint stress (RS) reduced the branching and increased the process dynamics of microglia in dmPFC.


    Contact with microglia makes it easier to eliminate dendritic spines.


    Contact with microglia makes it easier to eliminate dendritic spines.


    The experiment found that 7 7 days of restraint stress will damage the days of restraint stress impair 4- 4- selection odor discrimination test in reverse learning, this is a need complete selection odor discrimination test in reverse learning, this is a need Complete dmPFC dmPFC decision task decision task .


    In summary, this study shows that stress-induced glial stress-induced glial - - changes in synaptic interaction makes changes in synaptic interaction makes dmPFC dmPFC synapse loss, leading to neuronal circuits and defects identified Know that flexibility is impaired.


    Original source

    Taohui Liu, Ju Lu, Kacper Lukasiewicz, Bingxing Pan, Yi Zuo,Stress induces microglia-associated synaptic circuit alterations in the dorsomedial prefrontal cortex,Neurobiology of Stress,Volume 15,2021,100342,ISSN 2352-2895,https://doi .


    Taohui Liu, Ju Lu, Kacper Lukasiewicz, Bingxing Pan, Yi Zuo,Stress induces microglia-associated synaptic circuit alterations in the dorsomedial prefrontal cortex,Neurobiology of Stress,Volume 15,2021,100342,ISSN 2352-2895,https://doi .
    org/10.
    1016/j.
    ynstr.
    2021.
    100342.
    Taohui Liu, Ju Lu, Kacper Lukasiewicz, Bingxing Pan, Yi Zuo,Stress induces microglia-associated synaptic circuit alterations in the dorsomedial prefrontal cortex,Neurobiology of Stress,Volume 15,2021,100342 ,ISSN 2352-2895, https://doi.
    org/10.
    1016/j.
    ynstr.
    2021.
    100342.


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