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Neurology: Nasopharyngeal cancer survivors have an increased overall risk of stroke, especially in stage 1
Time of Update: 2021-12-03
Taking the Cancer and Stroke Disease Registry and the Singapore general population as the reference population, the age-standardized incidence difference (SIRDs) ratios (SIRs) of all causes of death within 30 days after stroke of nasopharyngeal cancer survivors are reported, as well as the cumulative incidence of stroke and all causes of death.
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NEJM: Autologous Hematopoietic Stem Cell Gene Therapy for Treatment of Children with Mucopolysaccharidosis Type I
Time of Update: 2021-12-03
Recently, researchers investigated the therapeutic effect of autologous hematopoietic stem cell and progenitor cell (HSPCs) gene therapy on children with MPSI .
Recently, researchers investigated the therapeutic effect of autologous hematopoietic stem cell and progenitor cell (HSPCs) gene therapy on children with MPSI .
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Alz Res Therapy: Eye tracking task, which can predict emotion recognition disorders in frontotemporal dementia
Time of Update: 2021-12-03
05) ;In a simple emotion recognition task, the average (standard deviation) change score of the stay time in the target area of interest in the control group was 35 (27)%, while the bvFTD group had only 4 (18)% (P<0.
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Knowledge card diagnosis flowchart of adult late-onset Pompe disease
Time of Update: 2021-12-03
Glycogen Accumulation Disease Type II (GSD II, OMIM232300), also known as Pompe disease, is a rare hereditary due to a genetic defect in the GAA gene encoding acid alpha glucosidase (GAA) in the lysosome, that is, acid maltase Metabolic myopathy .
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NEJM: Efficacy of intravenous alteplase before endovascular treatment in stroke patients
Time of Update: 2021-12-03
The researchers evaluated the superiority of EVT alone over alteplase combined with EVT, as well as the non-inferiority of the odds ratio of the two test groups and the lower limit of the 95% confidence interval of 0.
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NEJM: The blood vessels in the brain form a "sponge shape"?
Time of Update: 2021-12-03
The researchers found that in mice expressing one of the two common genetic drivers of meningiomas in PGDS-positive cells-Pik3caH1047R or AKT1E17K, a typical lineage of CCMs (22% and 11% of mice, respectively) , Rather than meningioma, which prompted them to analyze tissue samples of sporadic CCMs from 88 patients .
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Alz Res Therapy: Fudan University: Hereditary hypotension, lower risk of dementia
Time of Update: 2021-12-03
In observational studies, a new method of using genetic variation to estimate the causal effects of risk factors is Mendelian randomization (MR) .
A study used 24 single nucleotide polymorphisms (SNPs), showing that genetically predicted higher systolic blood pressure (SBP) is causally related to lower AD risk .
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Neurology: Optimizing the early blood pressure management of intravascular thrombectomy for acute ischemic stroke can improve patient prognosis
Time of Update: 2021-12-03
The increase in the average systolic blood pressure level within 24 hours after EVT is independently associated with the increased chances of symptomatic intracranial hemorrhage, early neurological deterioration, 3-month mortality, and 3-month poor prognosis .
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NEJM: "Changing evil and returning to the right"?
Time of Update: 2021-12-03
In this phase 2 double-blind randomized controlled trial involving patients with long-standing moderate to severe depression, the researchers compared siloxibin with the SSRIs escitalopram for a period of 6 weeks .
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JAMA Neuro: Go exercise!
Time of Update: 2021-12-03
At the same time, there is an obvious anti-dose response relationship between the total amount of PA activity and mortality (HRs: severe=0.
At the same time, there is an obvious anti-dose response relationship between the total amount of PA activity and mortality (HRs: severe=0.
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Radiology: When encountering patients with acute ischemic stroke, we must check for these signs!
Time of Update: 2021-12-03
Recently, published in a journal Radiology study analyzed 24 hours of follow-up scan of qualitative and quantitative variables infarction CT and diffusion-weighted MRI can see, discusses the clinical pattern infarction and infarct volume of tissue for specific prognostic impact , It provides a reference diagnosis for the early diagnosis and treatment evaluation of the prognosis of acute stroke patients .
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Alz Res Therapy: How does angiotensin antihypertensive drug affect cognitive function?
Time of Update: 2021-12-03
In APOE ε4 non-carriers with AD, the use of ARB is associated with greater preservation of memory and attention/psychomotor processing speed, especially when compared to ACE-Is that do not cross the blood-brain barrier .
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Alz Res Therapy: Data-driven PET analysis is conducive to the classification of dementia
Time of Update: 2021-12-03
In view of the fact that the "AD typical" hypermetabolic pattern detected by visual inspection of individual patients' FDGPET scans is usually used for differential dementia diagnosis in research and clinical settings , systematically assess whether and how specific AD neurodegenerative subtypes are reflected in FDG-PET The data may have important diagnostic significance .
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Alz Res Therapy: Hypometabolic anterior cingulate gyrus can predict frontotemporal dementia
Time of Update: 2021-12-03
explored whether P301L MAPT mutation carriers have asymptomatic neuronal dysfunction measured by FDG-PET, and whether the pattern of low metabolism is different from the pattern of atrophy .
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Lancet Psychiatry: In addition to drugs, psychosocial intervention is of great significance to the treatment of schizophrenia!
Time of Update: 2021-12-03
In order to comprehensively evaluate the efficacy, acceptability and tolerability of psychosocial and psychological interventions in preventing the recurrence of schizophrenia, experts from the Department of Psychiatry and Psychotherapy of the Faculty of Medicine of the Technical University of Munich conducted a systematic review and network meta-analysis The results were published in the journal Lancet Psychiatry .
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Radiology: DTI helps identify brain structural changes in people with genetic risk of early-onset AD
Time of Update: 2021-12-03
published a research article in the journal Radiology to assess the differences in the structural connections of the cortical network between the cognitively normal autosomal dominant Alzheimer's disease (ADAD) mutation carriers and non-carriers, and to determine the structural connections and cortex The cross-sectional relationship between amyloid load and estimated years of onset of dementia (EYO) .
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Neuromodulation: The dorsal root ganglion as a new neuromodulation target induces a strong and reproducible motor response in chronic motor complete spinal cord injury: a study of 5 patients
Time of Update: 2021-12-03
This article proves for the first time that bilateral L4 dorsal root ganglion stimulation can cause a reproducible upper limb motor response, which is sufficient to assist patients with chronic motor complete spinal cord injury to bear weight .
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JNNP: Interocular differences and atrophy progression in the diagnosis of multiple sclerosis
Time of Update: 2021-12-03
Similar to the rate of atrophy, the IEPD and IEAD of MS and HCs patients did not change substantially over time .
Similar to the rate of atrophy, the IEPD and IEAD of MS and HCs patients did not change substantially over time .
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Alz Res Therapy: Blood GFAP can predict future dementia in advance
Time of Update: 2021-12-03
There is currently no study on patients with mild cognitive impairment (MCI), specifically investigating whether plasma GFAP can predict future conversion to AD dementia .
Plasma GFAP can detect the pathology of AD in MCI patients and predict the conversion to AD dementia .
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Stroke: Imaging features of patients with mild ischemic stroke with intracranial occlusion
Time of Update: 2021-12-03
Compared with patients with a score of >5 on the National Institutes of Health Stroke Scale, in mild patients, the time from symptom onset to evaluation (start to computed tomography [240 vs.
