JAMA Neuro: Go exercise!

Parkinson's disease (PD) is the second largest neurodegenerative disease in the world and is characterized by motor retardation, limb stiffness, and tremor
.

PD patients may also have cognitive and behavioral problems.

Parkinson's disease (PD) is the second largest neurodegenerative disease in the world and is characterized by motor retardation, limb stiffness, and tremor

In the past, some scholars believed that physical activity (PA) has a protective effect on the development of PD; however, the relationship between PA and the mortality of PD is still unclear

From 2010 to 2013, use the code G20 of the tenth revision of the International Statistical Classification of Diseases and Related Health Problems and the registration code V124 in the Rare and Refractory Disease Program to select individuals newly diagnosed with PD
.

PA levels are collected through self-reported questionnaires

Results The study identified a total of 45,923 people; 10,987 people were included, and 34 people younger than 40 years old and 254 people with missing data were excluded
.

A total of 10699 PD patients were included; 4925 (46%) were men, 5774 (54%) were women, and the average (SD) age was 69.

In general, at all PA intensities, compared with people who are not physically active, the mortality rate of physically active people is reduced by 19%-34% (severe: hazard ratio = 0.
80 [95% CI, 0.
69-0.
93]; Moderate: HR=0.
66 [95% CI, 0.
55-0.
78]; mild: HR=0.
81 [95% CI, 0.
73-0.
90])
.

At all PA intensities, compared with people who are not physically active, the mortality rate of physically active people is reduced by 19%-34% (severe: hazard ratio=0.
80 [95%CI, 0.
69-0.
93]; moderate: HR= 0.
66 [95% CI, 0.
55-0.
78]; mild: HR=0.
81 [95% CI, 0.
73-0.
90])
.

At all PA intensities, compared with people who are not physically active, the mortality rate of physically active people is reduced by 19%-34% (severe: hazard ratio=0.

The relationship between the amount of exercise and the progression of Parkinson's disease

The relationship between the amount of exercise and the progression of Parkinson's disease

At the same time, there is an obvious anti-dose response relationship between the total amount of PA activity and mortality (HRs: severe=0.
80 [95% CI, 0.
69-0.
93]; moderate=0.
66 [95% CI, 0.
55-0.
78]; mild =0.
81[95% CI, 0.
73-0.
90]; P <.
001)
.

In addition, maintaining PA is associated with mortality

At the same time, there is an obvious anti-dose response relationship between the total amount of PA activity and mortality (HRs: severe=0.

PD patients who performed physical exercises before and after diagnosis had the largest reduction in mortality among all PA intensities, with the highest reduction of 51% (HRs: severe=0.

In summary, there is a dose-response relationship between PA and all-cause mortality in PD

references:

Association of Physical Activity, Including Amount and Maintenance, With All-Cause Mortality in Parkinson Disease.

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