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JNNP: Interocular differences and atrophy progression in the diagnosis of multiple sclerosis

 Last Update: 2021-12-03
 Source: Internet
 Author: User

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The potential role of optical coherence tomography (OCT) of the retina in the diagnostic criteria for multiple sclerosis (MS) has been determined
.

OCT can detect retinal atrophy caused by optic neuritis with high sensitivity, accuracy and repeatability

Several studies have now provided evidence that these retinal asymmetry measures can reliably identify past episodes of MS-related optic neuritis (MSON)

So far, retinal asymmetry has only been applied to cross-sectional datasets
.

It is currently unknown how effective it is to measure changes in retinal asymmetry over time

Therefore, this prospective longitudinal study explored the diagnostic value of DIS and DIT in retinal asymmetry

In this prospective study, MS patients and healthy control (HC) subjects were included in the study
.

All subjects underwent clinical and OCT assessments at baseline, 2 years, and 4 years

Spectral domain OCT (Spectralis, Heidelberg Engineering Company, Heidelberg, Germany) was performed.
The OCT quality assessment was based on validated and consistent standards, and the thickness of macular ganglion cells, inner plexiform layer (mGCIPL) and parapapillary nerve fiber layer were measured
.

The interocular difference of mGCIPL was calculated as described above

Block diagrams of (A) Inter-eye Percentage Difference (IEPD) and (B) Inter-eye Absolute Difference (IEAD) at baseline inspection

A total of 151 MS patients and 27 HCs patients were included
.

The average course of the patient's disease was 20.

A total of 151 MS patients and 27 HCs patients were included

Due to this low discriminating ability, the relevant diagnostic cut-off value for atrophy rate cannot be determined

The 5% cut-off value of the IEPD results in a sensitivity value between 41% and 49%

Bijvank NijJ ,UitdehaagBMJ ,Petzold A NIJ BijvankJNIJ Bijvank UitdehaagBMJUitdehaag Petzold A PetzoldARetinal and Inter-Eye -difference Multiple sclerosis Diagnostics atrophy progression inJournal of.

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