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Neuromodulation: The dorsal root ganglion as a new neuromodulation target induces a strong and reproducible motor response in chronic motor complete spinal cord injury: a study of 5 patients

 Last Update: 2021-12-03
 Source: Internet
 Author: User

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Spinal cord injury (SCI) is one of the most destructive injuries to the human central nervous system, causing many problems, including loss of autonomic nerve control, muscle atrophy, spasms, and most prominently sensory and motor injuries
.

Sports injury originates from the disconnection between the descending pathway and the injured caudal spinal cord circuit, depriving the latter of the necessary nerve input to generate and control the motor response

The dorsal root ganglion (DRG) contains the first-level neurons of the sensory pathway and is therefore responsible for a series of sensory processes, such as pain (pain), mechanical sensation (pressure), and proprioception (position in body space)
.

Although the importance of afferent input to motor recovery after spinal cord injury has been reported, DRG itself has not been used as a stimulus source to stimulate the motor response of patients with spinal cord injury

The purpose of this study is to demonstrate for the first time the possibility of DRG stimulation as a new target for neuromodulation in patients with exercise-induced complete spinal cord injury

Experimental flowchart

For each patient, the study period is five days in total
.

On day 1, the patient received temporary electrode placement for non-surgical resection at the end of the study period

Patient training

In all patients, DRG stimulation induced MRC phase 1 and phase 2 motor responses ≥ 4 all thigh muscles (rectus femoris, lateral femoris, medial femoris, and biceps femoris) (p

This article proves for the first time that bilateral L4 dorsal root ganglion stimulation can cause a reproducible upper limb motor response, which is sufficient to assist patients with chronic motor complete spinal cord injury to bear weight
.

Soloukey, S.

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