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Investigate the brain mechanism of the impact of sexism on pain perception
Time of Update: 2021-11-05
Past neuroimaging studies have found that experiencing social pain can activate brain areas related to physical pain, such as the dorsal anterior cingulate cortex (dACC), basal nucleus, etc.
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Nature cover is heavy!
Time of Update: 2021-11-05
Researchers such as Sjors HW Scheres and Michel Goedert of the University of Cambridge in the United Kingdom published articles on Nature, classifying "tau protein diseases" based on different protein folding structures, and they were featured on the cover of Nature .
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Sci Transl Med︱ Xiang Xianyuan and others revealed the crazy sugar phagocytosis of brain immune cells to help early diagnosis of neurodegenerative diseases
Time of Update: 2021-11-05
Xiang Xianyuan (first author of the article), Matthias Brendel, Christian Haass (co-corresponding author) of the University of Munich and others published an online publication on Science Translational Medicine entitled "Microglial activation states drive glucose uptake and The article titled "FDG-PET alterations in neurodegenerative diseases" revises people's understanding of brain FDG-PET imaging and helps early diagnosis of neurodegenerative diseases .
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Adv Sci Ji Shengjian's group reveals the molecular mechanism of m6A modification regulating axon growth
Time of Update: 2021-11-05
202101329FCDB: https:// Platemaker: Notes for reprinting on the 11th [ Non-original articles] The copyright of this article belongs to the author of the article.
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How to make early diagnosis and treatment when encountering a comatose patient?
Time of Update: 2021-11-05
(2) Grading evaluation is based on a study published in the Chinese Journal of Neurology in 2005: 44 patients were enrolled, SLSEP and SLAEP were combined, and the results showed that: the sensitivity and sensitivity of predicting poor prognosis The specificity is improved, suggesting that multi-mode is better than single-mode .
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Nature: I never thought that fat is the "accomplice" of inflammatory astrocytes to kill neurons
Time of Update: 2021-11-05
After oligodendrocytes are cultured in a medium containing reactive glial cells, the expression of PUMA increases and caspase-3 is lysed, which indicates that the apoptosis signal pathway of adipocytes is enhanced .
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Science: A textbook discovery! Astrocytes regulate neural circuits through electrical activity
Time of Update: 2021-11-05
The expression of A2a adenosine receptor and HCN at the initial segment of axons and Langfei’s junction provides a rich material basis for astrocytes to regulate the electrical activities of neurons .
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Fudan Faifei Wong/Ma Lan team discovered neuronal clusters and loop mechanisms that cause negative emotions in morphine withdrawal
Time of Update: 2021-11-05
Recently, the research team of Feifei Wong/Ma Lan team from the Institute of Brain Science, Fudan University/State Key Laboratory of Medical Neurobiology, discovered that corticotropin releasing hormone (CRH) neurons in the central amygdala brain area and the ventral tegmental area (VTA) Inhibitory neural circuits between reward neurons activated by morphine mediate negative emotions caused by morphine withdrawal .
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Cell reveals how male nematode mating behavior drives brain activity
Time of Update: 2021-11-05
Finally, the researchers combined functional imaging, behavior analysis, and single neuron manipulation to analyze in detail the neural circuits in different mating behavior modules, and explain the mechanisms that diversify the brain's activity patterns and give each neuron unique functional characteristics .
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Does missing teeth affect brain health?
Time of Update: 2021-11-05
After adjusting for the effects of other factors, the researchers found that tooth loss was associated with an increased risk of cognitive impairment and dementia in participants.
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"Agatroban in the Treatment of Acute Ischemic Stroke Chinese Expert Consensus 2021" Highlights Quick View of Stroke "Miscellaneous" Issue 11
Time of Update: 2021-11-05
Antiplatelet drugs ① For patients with moderate ischemic stroke (NIHSS 5-15 points) and low bleeding risk, it is recommended to treat argatroban combined with aspirin [weak (limited conditions) recommendation , Moderate-quality evidence] .
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How to diagnose "vestibular migraine" more accurately based on the characteristics of eye movements?
Time of Update: 2021-11-05
Figure 1: VM diagnostic criteria jointly developed by the Barrány Association and the International Headache Society in 2012 (Source: Professor Ju Yi's PPT) Vestibular migraine eye movement abnormal types 1.
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Express about 380 million US dollars to help develop gene therapy to treat epilepsy, Spark reached a cooperation
Time of Update: 2021-11-05
▎The content team editor of WuXi AppTec recently, Spark Therapeutics, a subsidiary of Roche, announced that it has reached an exclusive cooperation and licensing agreement with CombiGene on the research-in-progress gene therapy CG01, aimed at the treatment of drug-resistant focal epilepsy .
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Roche and CombiGene sign an agreement to develop AAV gene therapy for the treatment of drug-resistant epilepsy
Time of Update: 2021-11-05
Recent popular reports from Yimaike ★Medical ClassApplication and prospects of CAR-T cell technology in the functional cure of AIDS EMedClub PR News/--Recently, Roche's gene therapy company Spark Therapeutics and Swedish gene therapy company CombiGene announced the signing of an exclusive cooperation and licensing agreement for the CG01 project, a project designed to treat drug-resistant focal epilepsy Research-based gene therapy .
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Express significantly reduces inflammation indicators in patients with multiple sclerosis, and the phase 2 clinical results of brain-permeable BTK inhibitors are positive
Time of Update: 2021-11-05
▎Editor of WuXi AppTec content team Recently, Merck KGaA of Germany announced the post-mortem analysis data of a phase 2 clinical trial of the brain-permeable BTK inhibitor evobrutinib for the treatment of patients with multiple sclerosis (MS) .
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Headache for August, weakness of the right limb with speech failure for 10 days, what do you think about it?
Time of Update: 2021-11-05
Combined with the patient's headache, fever, and rapid erythrocyte sedimentation rate in experimental examinations, TB-SPOT is positive, and imaging shows that the blood vessel wall is thickened and the lumen is narrow.
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Reprogramming of neural circuits in the hippocampus of the adult brain induced by a single transcriptional regulator Id2 in PNAS
Time of Update: 2021-11-05
The granulosa cells in the hippocampus of healthy mice and rats express the transcriptional regulator Id2, which successfully drives specific molecular programs, induces the growth of mature neuron axons, and establishes synaptic connections with target neurons.
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12-year follow-up study: How harmful is poor blood glucose control?
Time of Update: 2021-11-05
A recent study published in the journal "Alzheimer's & Dementia" found that diabetes, which is characterized by poor blood sugar control or cardiovascular complications, is associated with an increased risk of developing cognitive impairment; Inflammation may play an important role in the process .
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Interpretation of the latest basic and clinical research on ECTRIMS 2021 in multiple sclerosis
Time of Update: 2021-11-05
EXPAND’s post-event analysis study evaluated the effects of sinimod treatment on EDSS, 9-hole peg test (9HPT), and timed 25-foot walk test (ambulation) in patients with secondary progressive multiple sclerosis (SPMS).
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The 2021 primary diagnosis and treatment guidelines for ischemic stroke are released. These 5 details should be known!
Time of Update: 2021-11-05
In September 2021, "Chinese Journal of General Practitioners" published "Guidelines for Primary Diagnosis and Treatment of Ischemic Stroke (2021)" (hereinafter referred to as non-practical version) and "Guidelines for Primary Diagnosis and Treatment of Ischemic Stroke (Practical Edition 2021)" ( Hereinafter referred to as the practical version) (Figure 1), "Medical Neurology Channel" will take you into these two guides .
