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Science: A textbook discovery! Astrocytes regulate neural circuits through electrical activity
Time of Update: 2021-11-05
The expression of A2a adenosine receptor and HCN at the initial segment of axons and Langfei’s junction provides a rich material basis for astrocytes to regulate the electrical activities of neurons .
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The 2021 primary diagnosis and treatment guidelines for ischemic stroke are released. These 5 details should be known!
Time of Update: 2021-11-05
In September 2021, "Chinese Journal of General Practitioners" published "Guidelines for Primary Diagnosis and Treatment of Ischemic Stroke (2021)" (hereinafter referred to as non-practical version) and "Guidelines for Primary Diagnosis and Treatment of Ischemic Stroke (Practical Edition 2021)" ( Hereinafter referred to as the practical version) (Figure 1), "Medical Neurology Channel" will take you into these two guides .
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Nature: I never thought that fat is the "accomplice" of inflammatory astrocytes to kill neurons
Time of Update: 2021-11-05
After oligodendrocytes are cultured in a medium containing reactive glial cells, the expression of PUMA increases and caspase-3 is lysed, which indicates that the apoptosis signal pathway of adipocytes is enhanced .
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How to diagnose "vestibular migraine" more accurately based on the characteristics of eye movements?
Time of Update: 2021-11-05
Figure 1: VM diagnostic criteria jointly developed by the Barrány Association and the International Headache Society in 2012 (Source: Professor Ju Yi's PPT) Vestibular migraine eye movement abnormal types 1.
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How effective are neuroprotective agents?
Time of Update: 2021-11-04
Clinical research results: Phase IIb and III According to the summary data of clinical trials, it is safe to start HUK within 48 hours after the onset of symptoms, and as a treatment method for acute ischemic stroke, regardless of age, gender, and complications, it has potential clinical benefits .
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The symptoms of a brain infection resemble a stroke, but the operation found that the cotton swab was left behind!
Time of Update: 2021-11-04
Recently, the medical journal CHEST published such a case where the residual cotton swab eventually caused a brain infection .
This case was published in the medical journal CHEST under the title "Cotton Swab Today, Brain Infection Tomorrow".
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Nature: Don't know how to comfort people, the amygdala is back?
Time of Update: 2021-11-04
On October 13, 2021, the Weizhe Hong research team at the David Geffen School of Medicine at the University of California, University of California, discovered that mice performed comforting behaviors to mice that had been stressed, and further revealed inhibitory neurons that express tachykinin in the medial amygdala The neural circuit projecting to the medial preoptic zone mediates this comforting behavior .
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Sleeping in is really cool, but the price is that cognitive ability may be impaired...
Time of Update: 2021-11-04
With age, the decline in individual sleep quality and the increase in Alzheimer's risk will affect the cognitive function of the brain .
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Nature: The neural circuit mechanism of estrogen driving an active lifestyle
Time of Update: 2021-11-04
(Referred to as VMHvl-ERα neuron) after weight gain, nocturnal activity decreases; but knocking out the estrogen receptor-α in the arcuate nucleus of the hypothalamus does not cause this change .
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The most complete summary of the causes of "Middle-aged and Young People Stroke", with pictures and detailed explanations of the cases!
Time of Update: 2021-11-04
Professor Liu introduced a case: a 29-year-old female, the main cause was "abrupt loss of left eye with headache and dizziness for 3 days during rhinoplasty surgery" .
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STM｜Xianyuan Xiang and others revealed that microglia-mediated inflammation changes brain energy metabolism and helps early diagnosis of neurodegenerative diseases
Time of Update: 2021-11-04
In this study, the authors analyzed whether glucose-PET imaging results are directly affected by the glucose uptake of microglia in mouse models and patients with neurodegenerative diseases .
Personal forwarding and sharing are welcome, and it is prohibited without permission Reprinted, the author has all legal rights, offenders must be investigated194-206 (1993).
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PNAS｜Song Jianren/Hua Yunfeng jointly discovered new interneurons in the spinal cord to analyze new behavioral decision mechanisms
Time of Update: 2021-11-04
Recently, Professor Song Jianren of Tongji University, Professor El Manira of Karolinska Institutet, and Researcher Hua Yunfeng of Shanghai Institute of Precision Medicine published a research paper in PNAS: A specialized spinal circuit for command amplification and directionality during escape behavior .
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Nat Metab Rao Feng/Dynasty's team discovered a new messenger in the GPCR pathway that regulates vesicle secretion and metabolic homeostasis: IP7
Time of Update: 2021-11-04
Rao Feng's research group from the School of Life Sciences of Southern University of Science and Technology is mainly studying the functional mechanism of emerging small molecule messengers in cells represented by high-grade inositol polyphosphate .
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Always eating processed foods will make the brain lose memory?
Time of Update: 2021-11-04
The good news is that research has also found that as long as the omega-3 fatty acid DHA is added to the diet, it can effectively slow down or prevent the damage to the brain from processed foods .
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Nature's new understanding of a new mechanism by which astrocytes "toxic" neurons-related to metabolism
Time of Update: 2021-11-04
In order to identify specific toxic factors, the authors analyzed the changes in protein abundance in reactive glial cells and control (resting) glial cells and astrocyte conditioned medium (ACM) (Figure 1), and use mature oligodendrocytes to assess the toxicity of ACM .
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Nat Commun︱non-human primate (monkey marmoset) autism model reveals the biological abnormalities in the early development of human diseases
Time of Update: 2021-11-04
Figure 5 The relationship between VPA-induced marmosets and human ASD gene expression regulation (Figure quoted from: Watanabe S, et al.
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Conquer the dawn of Alzheimer's disease!
Time of Update: 2021-11-04
The scientific performance proves that this composite material can improve the efficiency of crossing the blood-brain barrier and target neurons, eliminate excessive ROS in cells, maintain mitochondrial membrane potential and calcium ion levels, inhibit the production and aggregation of Aβ, and reduce nerves Inflammation, protect neurons, and further improve the cognitive impairment of AD mice, can effectively alleviate the symptoms of AD .
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Viral infection or related to neurodegenerative diseases?
Time of Update: 2021-11-04
"Nature-Communication" published a proof-of-concept study in mammalian cells, Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions, and found that glycoproteins on the surface of viruses that help them enter target cells may promote neurodegeneration Proliferation of protein polymers in sexual diseases .
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Interview with Prof. Ying Han: New advances in early diagnosis and treatment of Alzheimer's disease
Time of Update: 2021-11-04
After the meeting, Yimaitong had the honor to interview the chairperson of this conference, Professor Han Ying, to explain the new progress in early diagnosis and treatment of AD.
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Dev Cell︱ Lactic acid promotes peripheral nerve injury and repair B side: Long-term increase in lactic acid metabolism of axons can lead to oxidative stress and axon degeneration
Time of Update: 2021-11-04
Figure 5 The massive input of lactic acid into the Schwann cells of Rheb cKO mice caused the mitochondria in the sciatic nerve to overload and produce high doses of ROS (picture quoted from: Jia et al.
