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Brain: Sleep disorders related to impaired brain microcirculation may indicate early signs of Parkinson's disease
Time of Update: 2021-08-02
At the same time, researchers have observed that abnormal cortical blood flow in RBD patients may be related to impaired neurogenic control and the degree of cognitive dysfunction .
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Science: Scientists have discovered a new type of memory cells in the brain
Time of Update: 2021-08-02
Recently, a new study published in the journal Science showed that there is a type of neurons in the temporal poles of the brain that connect facial perception with long-term memory .
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Ann Neurol: The characteristics of intestinal microbes can effectively predict Parkinson's
Time of Update: 2021-08-02
Several markers of pre-PD established in the research standards of the International Parkinson and Dyskinesia Society (MDS) are also related to changes in intestinal microbes by age and the International Society for Parkinson and Movement Disorders (MDS); these markers include risk markers such as men, diabetes , non-smokers and non-use Caffeine and precursor markers such as RBD, constipation, and depression .
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Nature: Obesity really causes hair loss!
Time of Update: 2021-08-02
However, after 3 months of high-fat diet, the number of hair follicle stem cells in the bulge area was significantly reduced, and the differentiated progeny cells migrated closer to the skin .
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Alzheimers Dement: Small vessel disease is better than Alzheimer's disease in determining the diffusion MRI changes in clinical patients with memory
Time of Update: 2021-08-02
Blood vesselThe microstructural changes assessed by diffusion tensor imaging (DTI) are key findings in Alzheimer's disease (AD) and small vessel disease (SVD) .
Simple linear regression analysis between diffusion measurements and Alzheimer's disease (AD) biomarkers or small vessel disease (SVD) markers .
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IEEE trans: Evaluation of Fugl-Meyer Upper Limb Motion Score in Stroke Patients from Functional Connectivity Measurements
Time of Update: 2021-08-02
Use the PLI processing algorithm and four determined connected channels (F7-F3, FP2-F7, F8-C4, and FC2-CZ) to perform PLSR analysis on the training set at a medium alpha frequency (11 Hz) to generate a set of regression coefficients, It is then used to predict the FMU of stroke participants in the test set .
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Brain Structure and Function: There are abnormalities in the gray matter network of early Parkinson's patients
Time of Update: 2021-08-02
In addition, since recent studies have shown that connective measurements have diagnostic value in brain diseases, it is assumed that the GM network matrix and graph-based metrics will distinguish PD patients from HC and different motor subtypes at the individual level with significant accuracy .
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Ann Neurol: Columbia University found that: genetic risk score can effectively predict Alzheimer's disease
Time of Update: 2021-08-02
In fact, early studies used European ancestry GWAS to construct the PRS of other ethnic groups due to the lack of large-scale matching genetic studies, and the results were not satisfactory .
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Ann Neurol-Multiple sclerosis, the "effect" of the intestinal flora is extraordinary
Time of Update: 2021-08-02
They sequenced the microbiota of healthy controls, relapsing multiple sclerosis (RRMS), and progressive multiple sclerosis patients, and correlated bacterial levels with clinical features of the disease, including an expanded disability status scale ( EDSS), quality of life, and brain magnetic resonance imaging lesions/atrophy .
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EClinicalMedicine: Heavy!
Time of Update: 2021-08-02
A recent study published in EClinicalMedicine has once again subverted the traditional view that the accumulation of amyloid beta plaques in the brain is the cause of Alzheimer's disease .
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Brain lacunar infarction, white matter hyperintensity, ischemic white matter lesions... these are the main causes of stroke and dementia!
Time of Update: 2021-08-02
The hot spots and the average volume of the blood-brain barrier permeability of the normal white matter in the sporadic SVD group are all related to dimension 1 (β = 0.
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JNNP: Long-term changes in cognitive and daily function decline before and after stroke
Time of Update: 2021-08-02
Vascular stroke preventionBetween 1990 and 2016, our subjects’ cognitive abilities (Mini Mental State Examination (MMSE), 15-character learning, letter-number substitution, Stroop, language fluency, Purdue nail board) and basic daily tools activities (BADL and IADL) repeated evaluations .
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JECH: The calculator can predict the risk of dementia!
Time of Update: 2021-08-02
Recently, Canadian researchers from the Ottawa Hospital, the University of Ottawa, the Bruyere Institute, and ICES have established and verified an online calculator that enables people 55 and older to better understand their brain health and They are at risk of being diagnosed with dementia within the next five years .
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Ann Neurol-Fully automatic speech analysis, may assist Parkinson's diagnosis
Time of Update: 2021-08-02
The objectives are: (1) What are the possible differences in motor speech abnormalities among the 5 Indo-European languages, (2) Which speech patterns are most sensitive to iRBD and early PD, (3) Whether speech analysis can be within 12 months The progress of the disease was found in the follow-up evaluation .
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Stroke: Analysis of related risk factors for delirium after stroke
Time of Update: 2021-08-02
Quantile regression showed that PSD-related care and total costs increased, the National Institutes of Health stroke scale was higher, and hospital stays were longer (all P<0.
PSD is associated with more severe strokes, longer hospital stays, and increased care and total costs .
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Science: Crack the mystery of "face blindness"!
Time of Update: 2021-08-02
This new study reveals the mechanism of human face recognition: There are a class of neurons in the temporal poles of the brain that can link face perception with long-term memory .
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Ann Neurol-Blood-brain barrier destruction is closely related to cognitive decline
Time of Update: 2021-08-02
In vivo studies also showed that compared with healthy controls, patients with cognitive impairment had a higher concentration of blood-derived albumin in the cerebrospinal fluid (CSF), which indicated that the BBB was destroyed .
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Cerebral Cortex: Regular physical activity is linked to a "healthier" brain
Time of Update: 2021-08-02
1093 /cercor/bhab126 References : Skylar J Brooks, Sean M Parks, Catherine Stamoulis, Widespread Positive Direct and Indirect Effects of Regular Physical Activity on the Developing Functional Connectome in Early Adolescence, Cerebral Cortex , 2021;, bhab126, https://doi.
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J Neurol Neurosurg Psychiatry: Cerebrovascular disease is a contributing factor for cerebral hemorrhage in patients on anticoagulation therapy
Time of Update: 2021-08-02
Cerebral small vessel disease (SVD) is the most common cause of non-traumatic spontaneous intracerebral hemorrhage (ICH).
A meta-analysis of randomized controlled trials showed that oral anticoagulants vitamin K antagonists and direct oral anticoagulants (apixaban, dabigatran, edoxaban, and rivaroxaban) are risk factors for cerebral hemorrhage .
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Ann Neurol-Strengthening blood pressure, it is indeed beneficial to improve acute cerebral hemorrhage
Time of Update: 2021-08-02
They used the data from the antihypertensive treatment of acute cerebral hemorrhage II (ATACH-2) trial to conduct an HE transition analysis on the response to enhanced blood pressure, according to a) the previously established definition of HE, b) the percentile of hematoma volume change/ Absolute quartile, c) The quartile of hematoma volume in the 24-hour follow-up, resulting in a multi-quantile layer .
