Ann Neurol: The characteristics of intestinal microbes can effectively predict Parkinson's

Gastrointestinal pathological α-synaptic protein deposition and the existence of constipation in the precursor and clinical establishment of Parkinson's disease (PD) indicate that the intestinal-brain axis plays an indispensable role in the early pathogenesis of PD
.

It is speculated that synaptopathies rise from peripheral neurons of the gastrointestinal tract to the brain through the vagus nerve

In addition, the increased intestinal permeability, increased fecal inflammatory cytokines, and inflammation of the colon wall in PD patients have been proven, which may also represent the key gastrointestinal process of the precursor PD
.

Mice overexpressing α-synuclein showed increased motor dysfunction after being colonized by the gut microbiota of PD patients

Mice overexpressing α-synuclein showed increased motor dysfunction after being colonized by the gut microbiota of PD patients

Based on these evidences, it is possible to define specific predictive values ​​for these markers, and calculate the probability of individual precursor PD based on age and marker conditions
.

Several markers of pre-PD established in the research standards of the International Parkinson and Dyskinesia Society (MDS) are also related to changes in intestinal microbes by age and the International Society for Parkinson and Movement Disorders (MDS); these markers include risk markers such as men, diabetes , non-smokers and non-use Caffeine and precursor markers such as RBD, constipation, and depression

These markers include risk markers such as men, diabetes , non-smokers and non-caffeine use, and prodrome markers such as RBD, constipation, and depression

In this way, Sebastian Heinzel and others of the University of Kiel in Germany evaluated the diversity, intestinal type and taxonomic composition of gut microbes, and investigated their relationship with a comprehensive set of PD risk and precursor markers, overall precursor PD probability and a large number of The relationship between other potential confounding factors
.

And investigated their relationship with a comprehensive set of PD risk and precursor markers, overall precursor PD probability, and a large number of other potential confounding factors
.

And investigated their relationship with a comprehensive set of PD risk and precursor markers, overall precursor PD probability, and a large number of other potential confounding factors

They found that among the risk and prodrome markers, non-exercise, occupational solvent exposure, and constipation were associated with α-diversity
.

Insufficient physical activity, gender, constipation, possible REM-sleep behavior disorder (RBD), and smoking are related to β-diversity
.

Subliminal Parkinson's disease and insufficient physical activity show an interactive effect

Among other factors, age and uric acid lowering drugs are related to α- and β-diversity
.

Constipation is highest in individuals with intestinal types rich in Firmicutes, while non-exercise is most common in intestinal types rich in Bacteroides
.

Pu Lei Wote coli enrichment of individuals constipation lowest rate, the lowest incidence of sub-threshold Parkinson's disease

Individuals enriched with Revotella have the lowest constipation rate and the lowest incidence of subthreshold Parkinson's disease

The important significance of this study is that some risk and precursor markers of PD were found to be related to the composition of the gut microbiome
.
However, the impact of the gut microbiome on the risk of PD and the potential microbiome-dependent subtypes in PD prodromal symptoms need to be further explored.
Of course, this requires prospective clinical and (multi) global data based on incident PD cases
.

, Found that some of the risks and precursor markers of PD are related to the composition of the gut microbiome , and found that some of the risks and precursor markers of PD are related to the composition of the gut microbiome

Original source:
Heinzel S, Aho VTE, Suenkel U, von Thaler AK, Schulte C, Deuschle C, Paulin L, Hantunen S, Brockmann K, Eschweiler GW, Maetzler W, Berg D, Auvinen P, Scheperjans F.
Gut microbiome signatures of risk and prodromal markers of Parkinson's disease.
Ann Neurol.
2021 May 22.
doi: 10.
1002/ana.
26128.
Epub ahead of print.
PMID: 34021620.

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