Alzheimers Dement: Small vessel disease is better than Alzheimer's disease in determining the diffusion MRI changes in clinical patients with memory

Alzheimer's disease (AD) and cerebral small vessel disease (SVD) are two main reasons cognitive decline and dementia
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The change in white matter microstructure is considered to be the key finding in these two situations, and has always been associated with cognitive deficits

Blood vessel

The microstructural changes assessed by diffusion tensor imaging (DTI) are key findings in Alzheimer's disease (AD) and small vessel disease (SVD)
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Sofia Finsterwalder et al.

Sofia Finsterwalder et al.

Research concept and participant selection flowchart
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The samples cover Alzheimer's disease (AD), mixed disease and small vessel disease (SVD)

Research concept and participant selection flowchart

Simple regression analysis
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Simple linear regression analysis between diffusion measurements and Alzheimer's disease (AD) biomarkers or small vessel disease (SVD) markers

Simple regression analysis

Multivariate analysis
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Random forest regression analysis is used to estimate Alzheimer's disease (AD) biomarkers (grey band), small vessel disease (SVD) markers (black band), age and gender (white band) relative to conventional spread Tensor imaging (DTI) measures relative variable importance (uncorrected partial anisotropy (FAu)), uncorrected mean diffusivity (MDu), while taking into account all other variables (conditional importance)

Multivariate analysis

SVD markers are closely related to diffusion indicators.

In clinical memory patients, changes in diffusion MRI are largely determined by SVD

In clinical memory patients, the influence of SVD on diffusion changes far exceeds that of AD, which supports the value of diffusion measurement as a marker of SVD
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In clinical memory patients, the influence of SVD on diffusion changes far exceeds that of AD, which supports the value of diffusion measurement as a marker of SVD
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Original source

Finsterwalder S, Vlegels N, Gesierich B, et al.
Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
Alzheimers Dement .
2020;16(11):1504-1514.
doi:10.
1002/alz.
12150

Finsterwalder S, Vlegels N, Gesierich B, et al.
Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
  Alzheimers Dement .
2020;16(11):1504-1514.
doi:10.
1002/alz.
12150 Finsterwalder S, Vlegels N, Gesierich B, et al.
Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.
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