EClinicalMedicine: Heavy!

Alzheimer's disease (AD) is the most common, irreversible and progressive form of dementia
.

The "World Report on Alzheimer's Disease 2018" shows that every 3 seconds, 1 patient with dementia occurs globally

Alzheimer's disease (AD) is the most common, irreversible and progressive form of dementia

Alzheimer's disease was widely known as the "long farewell" in the late 20th century due to the slow deterioration of brain function and memory

But is this drug really effective ? Many experts are skeptical ! In a recently published study of EClinicalMedicine again again again subvert the accumulation of β-amyloid plaques in the brain is the traditional view of the cause of Alzheimer's Disease

The team believes that cognitive impairment may be due to the reduction of soluble amyloid beta peptides rather than the corresponding accumulation of amyloid plaques
.

To test their hypothesis, they analyzed the brain scans and spinal fluid of 600 people who participated in the Alzheimer's Neuroimaging Program study, all of whom had amyloid plaques

The team believes that cognitive impairment may be due to the reduction of soluble amyloid beta peptides rather than the corresponding accumulation of amyloid plaques

NC: normal cognition; MCI: mild cognitive impairment; AD: Alzheimer's disease Aβ42: amyloid β peptide of 42 amino acids; Aβ40: amyloid β peptide of 40 amino acids

They also found that the level of soluble Aβ42 observed in NC (864.
00 pg/ml) was higher than that of MCI (768.
60 pg/ml) or AD (617.
46 pg/ml).
The higher soluble Aβ42 level was also associated with better neuropsychology.
Function is related to the larger size of the hippocampus, which is the most important area of ​​the brain for memory
.

Despite increased cerebral amyloidosis, normal cognition and hippocampal volume are associated with maintaining high levels of soluble Aβ42

They also found that the level of soluble Aβ42 observed in NC (864.

Compared with subjects with mild cognitive impairment and Alzheimer's disease, the adjustment analysis of amyloid-positive normal cognition
.

(A) Soluble Aβ42 levels in each diagnostic category; (B) Soluble Aβ42 levels in each diagnostic category in the CL tertiles

Compared with subjects with mild cognitive impairment and Alzheimer's disease, the adjustment analysis of amyloid-positive normal cognition

According to the authors, most people will develop amyloid disease as they get older, but very few people will develop dementia

The key finding of the study is that the symptoms of Alzheimer's disease seem to depend on normal levels

The research team is now working to test their findings in animal models
.
If successful, the treatments in the future may be very different from the treatments tried in the past two decades
.
Espay said that treatment may include increasing the normal soluble Aβ42 protein to keep the brain healthy while preventing the protein from hardening into plaque
.

references:

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with brain amyloidosis

DOI: https://doi.
org/10.
1016/j.
eclinm.
2021.
100988

DOI: https://doi.
org/10.
1016/j.
eclinm.
2021.
100988 Leave a message here