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Stroke patients show acute and accelerated declines in cognitive and daily functions immediately after the event
.
This decline is mainly due to accumulated cerebral small vessel disease, neurodegeneration and inflammation
Vascular stroke prevention
Between 1990 and 2016, our subjects’ cognitive abilities (Mini Mental State Examination (MMSE), 15-character learning, letter-number substitution, Stroop, language fluency, Purdue nail board) and basic daily tools activities (BADL and IADL) repeated evaluations
.
At the beginning of the study, on average every 4 years, participants were interviewed at home and received extensive physical and cognitive examinations at the research center
experiment process
BADL uses the disability index in the Stanford Health Assessment Questionnaire.
The index consists of 20 items and constitutes the eight components of physical activity: getting up, dressing and grooming, hygiene, eating, walking, grasping, reaching and moving
.
The item score from 0 to 3 is higher, indicating poorer ability (0: no difficulty, 1: some difficulty, 2: very difficult, 3: no)
management
Participants received a standardized questionnaire survey on health, drug use, and medical history at home every 4 years
.
Also underwent a physical examination at the research center
cholesterol
During the mean ±SD follow-up period of 12.
5±6.
8 years (maximum 28.
4 years), a total of 1662 participants had a stroke for the first time
.
The average age of 1662 cases of stroke at the time of occurrence was 80.
diagnosis
Cognitive and daily function changes before and after stroke
The trajectories of BADL and IADL for stroke patients in the future began to deviate from the stroke-free control group by ±8 years and the control group by ±7 years (Figure 3)
.
The difference between the trajectories of BADL and IADL at 2.
Compared with patients without stroke, the cognitive ability and daily function decline of stroke patients was greater in the 10 years before the first stroke
.
The results of the study indicate that cumulative brain pathology has a clinical impact before stroke
HeshmatollahA ,DommershuijsenLJ , Fani L Heshmatollah AHeshmatollah Dommershuijsen LJDommershuijsen Fani LFani, et alLong-term trajectories of decline in cognition and daily functioning before and after strokeJournal of Neurology, Neurosurgery & Psychiatry Published Online First: 06 July 2021 Published Online First: doi: 10.
1136/jnnp-2021-326043doi:leave a message here
