Brain lacunar infarction, white matter hyperintensity, ischemic white matter lesions... these are the main causes of stroke and dementia!

 Brain stroke is an acute cerebral vascular disease with high incidence, high morbidity and mortality and high, has become a serious impact on human health and disease
.

There are many factors that cause stroke.

 Brain stroke is an acute cerebral vascular disease with high incidence, high morbidity and mortality and high, has become a serious impact on human health and disease

If you compare the brain to the crown of a tree, water is transported to each leaf from thick to thin branches, and the last branches are the "small cerebral blood vessels

In many cases, small cerebral vascular disease has no obvious symptoms.
Many patients only find that the report of head MRI after physical examination says "white matter hyperintensity", "ischemic white matter lesions", and "old lacunar infarction".
And other descriptions
.

If you take it lightly at this time, as the disease progresses, some patients may experience a variety of symptoms

In many cases, small cerebral vascular disease has no obvious symptoms.

For example, it becomes difficult to complete some daily tasks, slower reactions, and easy to lose focus.

Recently, experts in clinical neuroscience from the University of Cambridge in the United Kingdom adopted a case-control design for sporadic SVD ( n = 20 ), single-gene SVD (cerebral autosomal dominant arterial disease with subcortical infarction and leukoencephalopathy, CADASIL ) and normal controls ( N=20 ) Two disease groups were studied
.

Recently, experts in clinical neuroscience from the University of Cambridge in the United Kingdom adopted a case-control design for sporadic SVD ( n = 20 ), single-gene SVD (cerebral autosomal dominant arterial disease with subcortical infarction and leukoencephalopathy, CADASIL ) and normal controls ( N=20 ) Two disease groups were studied
.

Using PET-MRI and the radioligand transporter 11C-PK11195 while microglial activation is measured, and using dynamic contrast-enhanced MRI permeability measurements of blood-brain barrier
.

The glial activation and the increase in blood-brain barrier permeability were determined to be greater than the 95th percentile of the

Using PET-MRI and the radioligand transporter 11C-PK11195 while microglial activation is measured, and using dynamic contrast-enhanced MRI permeability measurements of blood-brain barrier

Comparison of 11C-PK11195 between sporadic SVD and CADASIL
.

Comparison of 11C-PK11195 between sporadic SVD and CADASIL
.

The results showed that in sporadic SVD, in addition to the increase in average blood-brain barrier permeability (P <0.
001), the 11C-PK11195 combination (P = 0.
003) and blood-brain barrier permeability (P = 0.
007) in the white matter of normal appearance ) The hot spot volume has also increased
.

The results show that in sporadic sporadic in sporadic SVD in addition to the average blood-brain barrier permeability (P <0.
001), the normal appearance of white matter binding 11C-PK11195 (P = 0.
003) and through the blood brain barrier The hot spot volume of permeability (P = 0.
007) also increased
.

In SVD, in addition to the increase in average blood-brain barrier permeability (P <0.

However , no increase in the permeability of the blood-brain barrier was detected in CADASIL ; the combination of 11C-PK11195 had an insignificant increasing trend ( P = 0.

The BBB permeability and hot spots of 11CPK11195 binding in four different SVD subject groups (AD)
.

The BBB permeability and hot spots of 11CPK11195 binding in four different SVD subject groups (AD)
.

The 93 blood biomarkers
related to cardiovascular disease, inflammation, and endothelial activation were further measured for each participant , and principal component analysis was performed .
The results show that the first component is related to the permeability of the blood-brain barrier and microglial activation, while the hot spots and the average volume of the blood-brain barrier permeability of the normal white matter in the sporadic SVD group are related to dimension 1 (β = 0.
829 and β = 0.
976 )
.
The above-mentioned correlation is not related to the 11C-PK11195 combination
.
No association with blood markers was found in the CADASIL group
.

The 93 cardiovascular blood biomarkers related to cardiovascular disease, inflammation and endothelial activation were further measured for each participant , and principal component analysis was performed .
The results show that the first component is related to the permeability of the blood-brain barrier and microglial activation, while the scattered results show that the first component is related to the permeability of the blood-brain barrier and the activation of microglia, and the scattered results show that the first Each component is related to the permeability of the blood-brain barrier and microglial activation .
The hot spots and the average volume of the blood-brain barrier permeability of the normal white matter in the sporadic SVD group are all related to dimension 1 (β = 0.
829 and β = 0.
976 SVD BBB permeability values and the average volume of hot white matter of the group are associated with a dimension (β = 0.
829 = 0.
976 and beta] ) .
above but correlated ) .
) .
The 11C-PK11195 combination is not related .
No association with blood markers was found in the CADASIL group .

In short, in sporadic SVD, microglia activation and blood-brain barrier permeability increase, but the performance is different in different brain regions
.

In short, in sporadic SVD, microglia activation and blood-brain barrier permeability increase, but the performance is different in different brain regions
.
In short, in sporadic SVD, microglia activation and blood-brain barrier permeability increase, but the performance is different in different brain regions
.

 

 

references:

references:

Microglial activation and blood--brain barrier permeability in cerebral small vessel disease, Brain, Volume 144, Issue 5, May 2021, Pages 1361–1371, https://doi.
org/10.
1093/brain/awab003

Microglial activation and blood–brain barrier permeability in cerebral small vessel disease, Brain, Volume 144, Issue 5, May 2021, Pages 1361–1371, https://doi.
org/10.
1093/brain/awab003 Microglial activation and blood–brain barrier permeability in cerebral small vessel disease, leave a message here