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Cell Death Differ︱ Shaanxi Normal University Qi Yitao’s team discovered the molecular mechanism of SUMO modification regulating neurogenesis in adult mice
Time of Update: 2021-10-02
On August 31, 2021, Qi Yitao, Wu Hongmei of the School of Life Sciences of Shaanxi Normal University and Edward Yeh of the University of Arkansas jointly published an online report entitled "SENP2-PLCβ4 signaling regulates neurogenesis through the" in Cell Death and Differentiation (IF=15.
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Liqun Luo Science Heavy Review System Interpretation ︱ Neural circuit structure-the system that makes the brain "computer" run at high speed
Time of Update: 2021-10-02
Models and other different technologies study the different connection modes and functions between neurons, and discuss the possible situations of these loop structures in the process of development and differentiation, providing us with another comprehensive system of neural loop knowledge Summary .
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Neuron 2020 Top 10 Highly Cited Articles!
Time of Update: 2021-10-02
In brain slices, dopamine released from synapses increases Ca2+ in astrocytes, stimulates ATP/adenosine release, and inhibits excitatory synaptic transmission by activating presynaptic A1 receptors .
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Uncovering the mystery of the origin of Alzheimer's disease: Is the replication of prions in the human brain the culprit?
Time of Update: 2021-10-02
Recently, researchers from Case Western Reserve University in the United States published a research paper titled: Structurally distinct external solvent-exposed domains drive replication of major human prions in the journal PLOS Pathogens .
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Prevent protein misfolding, new discoveries by Chinese scholars guide new therapies for cancer and Alzheimer's disease
Time of Update: 2021-10-02
Experiments have shown that DAXX can prevent the misfolding, tangling and formation of extracellular plaques and intracellular aggregates of proteins related to neurodegenerative diseases, such as β-amyloid and α-synuclein .
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Sci Adv︱ heavyweight!
Time of Update: 2021-10-02
On September 1, 2021, Professor Weng Jiemin's team from East China Normal University and Professor Li Xuekun's team from Zhejiang University published a research paper entitled "Mutation-induced DNMT1 cleavage drives neurodegenerative disease" online on "Science Advances" .
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EMBO J︱ new discovery!
Time of Update: 2021-10-02
The study found that ARHGAP11B induced the expansion of mouse cortex and the increase of neurons can continue into adulthood, and significantly improved the memory ability of mice .
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NBT cholesterol functionalized ASO crosses the blood-brain barrier and knocks down genes in the brain
Time of Update: 2021-10-02
On August 12, 2021, the team of Professor Takanori Yokota from Tokyo Medical and Dental University published a work titled Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS in Nature Biotechnology, which they developed A cholesterol-modified DNA/RNA hybrid double-stranded oligonucleotide molecule (Chlo-HDOs) can be injected subcutaneously or intravenously to inhibit the expression of target genes in brain and spinal cord cells .
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Quiz: Diagnosis of myasthenia gravis. Have you mastered these 5 questions?
Time of Update: 2021-10-02
C. About 10% of patients who test negative for anti-AChR antibodies have a positive MuSK antibody test result.
Approximately 2%-4% of MG patients with negative AChR binding antibody test results will have regulatory antibodies, which is associated with an increased risk of thymoma .
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Study the functional connection between the ventral globus pallidus of the brain and the default network and the relationship between post-traumatic anhedonia symptoms
Time of Update: 2021-10-02
A few studies based on resting state functional magnetic resonance point out that post-traumatic anhedonia symptoms are related to the functional connection between the reward loop and the brain's default network nodes, but the results are few and inconsistent .
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Revealing the molecular mechanism of the "black hole" of multiple sclerosis iron deposition inflammation-lymphocyte-glia immune axis
Time of Update: 2021-10-02
In summary, this article analyzes the molecular characteristics of paramagnetic borderline inflammatory lesions in multiple sclerosis through single-cell nuclear sequencing technology, and finds that complement C1q is a key molecule that regulates the activation of microglia .
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Research finds that deep electrical stimulation of the prethalamic nucleus can improve working memory accuracy
Time of Update: 2021-10-02
In half of the randomly selected trials, the subjects’ anterior thalamic nucleus received electrical stimulation for 1 second (Figure 1) .
The behavioral results show that the subjects' working memory accuracy will be significantly improved for the trials of receiving electrical stimulation (Figure 2) .
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Neuron's new discovery of the mechanism of early drug addiction formation
Time of Update: 2021-10-02
The authors found that cocaine exposure did not change the expression of D2 receptors in the nucleus accumbens, but changed the efficacy of D2 receptor signaling and the sensitivity of D2 receptors to dopamine .
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The Qinchuan team discovered for the first time the molecular mechanism of the new coronavirus that can cross the blood-brain barrier and infect the brain
Time of Update: 2021-10-02
Tight junctions alteration" research paper, the study found that SARS-CoV-2 RNA was occasionally detected in the blood vessel wall and perivascular space and brain microvascular endothelial cells (BMEC) of infected K18-hACE2 transgenic mice .
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High-fat diet can destroy the biological clock, leading to overeating and obesity
Time of Update: 2021-10-02
The study shows that a high-fat diet can disrupt the brain's biological clock that controls satiety, leading to overeating and obesity .
In short, the study emphasized that a high-fat diet can disrupt the brain's biological clock that controls satiety, and ultimately lead to overeating and obesity .
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The abnormal timing of Cereb Cortex®MET tyrosine kinase signal transduction is a key mechanism affecting the development and behavior of normal cortical neural circuits in mice
Time of Update: 2021-10-02
A large number of neurodevelopmental studies have shown that the MET protein regulates the dendritic branching, dendritic spine morphology, excitatory synaptic maturation and cortical plasticity of excitatory pyramidal neurons by participating in multiple intracellular molecular pathways, as well as mediating developmental Signal transduction in the cortex and hippocampus [7, 8] .
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Science is uncharacteristic!
Time of Update: 2021-10-02
PAZ team from the University of California, San Francisco published a research paper titled "Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury" in Science.
The study used a mouse model of mild TBI (mTBI) and found a chronic increase in C1q expression in the corticothalamus .
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Cell︱ New Discovery!
Time of Update: 2021-10-02
This new study uses the Inscopix free behavior microscopic calcium imaging system to observe the excitability of different groups of midbrain motor region (MLR) neurons and found two spatially mixed glutamatergic groups: one connected to the spinal cord and the other Connect the basal ganglia .
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Express sword refers to a variety of neurodegenerative diseases, Xinrui receives 85 million US dollars in assistance
Time of Update: 2021-10-01
The funds obtained in this round of financing will be used to advance the development of innovative treatments for neurodegenerative diseases, including Parkinson's disease (PD), Gaucher disease (GD), Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) .
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Thrombolysis, dissection, infarction... twists and turns
Time of Update: 2021-10-01
According to the medical history, the patient has chest pain accompanied by numbness and weakness of the left lower extremity, physical examination of left lower extremity muscle strength, decreased left lower extremity pain and tactile sensation, and positive left Babinski sign.
