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Anhedonia refers to the defect of an individual's ability to evoke positive emotions under conditions that usually cause positive emotions
.
Anhedonia symptoms exist in a variety of mental disorders, and it is also a common adverse reaction after an individual experiences a traumatic event
.
A preliminary study by Wang Li's research group at the Key Laboratory of Mental Health of the Chinese Academy of Sciences found that anhedonia is an independent symptom dimension in post-traumatic stress disorder, which represents the impact of traumatic stress on the function of the positive valence system
.
Anhedonia has been proven to play an important role in the post-traumatic psychopathological process.
Understanding the biological basis of this symptom is of great significance for the early screening of trauma-related psychological diseases and the later precise intervention
.
However, the current research on the brain basis of anhedonia is mainly focused on patients with schizophrenia and depression, and there are not enough empirical studies to focus on the possible mechanism of post-traumatic anhedonia
.
Previous studies based on task-state functional magnetic resonance showed that the anhedonia symptoms of PTSD patients are closely related to abnormal reward function, and the lack of activation of reward loop-related brain regions (such as the ventral striatal nucleus accumbens) under reward conditions may be due to The neural basis for anhedonia
.
A few studies based on resting state functional magnetic resonance point out that post-traumatic anhedonia symptoms are related to the functional connection between the reward loop and the brain's default network nodes, but the results are few and inconsistent
.
Wang Li's research group collaborated with Israel Liberzon, a professor in the Department of Psychiatry at Texas A&M University, to conduct research on the possible neuroimaging basis of anhedonia symptoms in adult earthquake survivors in China
.
The study performed resting-state functional magnetic resonance imaging scans on 88 subjects, combined with whole-brain analysis and region-of-interest (ROI) analysis, and examined the resting-state functional connection related to the level of post-traumatic anhedonia symptoms Features
.
The results of the whole brain analysis showed that after controlling for gender, age and other PTSD symptoms, individuals with high PTSD anhedonia symptoms compared to individuals with low anhedonia symptoms, the left hemisphere of the brain ventral pallidus and bilateral posterior buckling The level of functional connectivity in the belt-back/precuneus region is lower (Figure 1)
.
Figure 1.
The results of whole brain analysis with the ventral pallidus of the left hemisphere as the seed point.
Further ROI analysis results show that the ventral pallidus of the left hemisphere and several main nodes of the default network, including the posterior cingulate gyrus and the left apex The functional connection of the cortex is weaker in individuals with high PTSD anhedonia symptoms (see Table 1)
.
There was no significant correlation between the functional connection between the ventral globus pallidus of the left hemisphere and the default network node and other symptom dimensions of PTSD
.
Table 1.
Comparison of the resting state functional connection between the left hemisphere ventral globus pallidus and the default network node between the high and low PTSD anhedonia groups.
The ventral globus pallidus is one of the important brain areas for coding reward motivation and reward consumption.
The nucleus accumbens jointly assumes the role of the reward center
.
The results of this study suggest that under the influence of traumatic stress, the functional connection of the ventral globus pallidus changes, causing abnormal reward processing functions and causing anhedonia
.
At the same time, the results of this study are also consistent with the findings of anhedonia in the cross-diagnostic research, and support that the collaborative work of the reward loop and the default network plays a key role in the generation and maintenance of the normal pleasure experience
.
Studies have speculated that the difficulty of switching between the two networks in different contexts is the possible neural mechanism of anhedonia response after traumatic stress
.
The research was supported by the National Natural Science Foundation of China (31971020, 31471004), the Ministry of Education Humanities and Social Sciences Key Research Base Project (16JJD190006), the Chinese Academy of Sciences Key Deployment Project (ZDRW-XH-2019-4) and the National Social Science Fund Project (20ZDA079) Funding
.
The research results have been published online in the Journal of Psychiatric Research
.
Paper information: Li, G.
, Cao, C.
, Fang, R.
, Liu, P.
, Luo, S.
, Liberzon, I.
, Wang, L.
(2021).
Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions.
Journal of Psychiatric Research, 140, 30-34.
https://doi.
org/10.
1016/j.
jpsychires.
2021.
05.
061 Source: Research by Wang Li, Key Laboratory of Mental Health, Chinese Academy of Sciences Group Lee Gen
.
Anhedonia symptoms exist in a variety of mental disorders, and it is also a common adverse reaction after an individual experiences a traumatic event
.
A preliminary study by Wang Li's research group at the Key Laboratory of Mental Health of the Chinese Academy of Sciences found that anhedonia is an independent symptom dimension in post-traumatic stress disorder, which represents the impact of traumatic stress on the function of the positive valence system
.
Anhedonia has been proven to play an important role in the post-traumatic psychopathological process.
Understanding the biological basis of this symptom is of great significance for the early screening of trauma-related psychological diseases and the later precise intervention
.
However, the current research on the brain basis of anhedonia is mainly focused on patients with schizophrenia and depression, and there are not enough empirical studies to focus on the possible mechanism of post-traumatic anhedonia
.
Previous studies based on task-state functional magnetic resonance showed that the anhedonia symptoms of PTSD patients are closely related to abnormal reward function, and the lack of activation of reward loop-related brain regions (such as the ventral striatal nucleus accumbens) under reward conditions may be due to The neural basis for anhedonia
.
A few studies based on resting state functional magnetic resonance point out that post-traumatic anhedonia symptoms are related to the functional connection between the reward loop and the brain's default network nodes, but the results are few and inconsistent
.
Wang Li's research group collaborated with Israel Liberzon, a professor in the Department of Psychiatry at Texas A&M University, to conduct research on the possible neuroimaging basis of anhedonia symptoms in adult earthquake survivors in China
.
The study performed resting-state functional magnetic resonance imaging scans on 88 subjects, combined with whole-brain analysis and region-of-interest (ROI) analysis, and examined the resting-state functional connection related to the level of post-traumatic anhedonia symptoms Features
.
The results of the whole brain analysis showed that after controlling for gender, age and other PTSD symptoms, individuals with high PTSD anhedonia symptoms compared to individuals with low anhedonia symptoms, the left hemisphere of the brain ventral pallidus and bilateral posterior buckling The level of functional connectivity in the belt-back/precuneus region is lower (Figure 1)
.
Figure 1.
The results of whole brain analysis with the ventral pallidus of the left hemisphere as the seed point.
Further ROI analysis results show that the ventral pallidus of the left hemisphere and several main nodes of the default network, including the posterior cingulate gyrus and the left apex The functional connection of the cortex is weaker in individuals with high PTSD anhedonia symptoms (see Table 1)
.
There was no significant correlation between the functional connection between the ventral globus pallidus of the left hemisphere and the default network node and other symptom dimensions of PTSD
.
Table 1.
Comparison of the resting state functional connection between the left hemisphere ventral globus pallidus and the default network node between the high and low PTSD anhedonia groups.
The ventral globus pallidus is one of the important brain areas for coding reward motivation and reward consumption.
The nucleus accumbens jointly assumes the role of the reward center
.
The results of this study suggest that under the influence of traumatic stress, the functional connection of the ventral globus pallidus changes, causing abnormal reward processing functions and causing anhedonia
.
At the same time, the results of this study are also consistent with the findings of anhedonia in the cross-diagnostic research, and support that the collaborative work of the reward loop and the default network plays a key role in the generation and maintenance of the normal pleasure experience
.
Studies have speculated that the difficulty of switching between the two networks in different contexts is the possible neural mechanism of anhedonia response after traumatic stress
.
The research was supported by the National Natural Science Foundation of China (31971020, 31471004), the Ministry of Education Humanities and Social Sciences Key Research Base Project (16JJD190006), the Chinese Academy of Sciences Key Deployment Project (ZDRW-XH-2019-4) and the National Social Science Fund Project (20ZDA079) Funding
.
The research results have been published online in the Journal of Psychiatric Research
.
Paper information: Li, G.
, Cao, C.
, Fang, R.
, Liu, P.
, Luo, S.
, Liberzon, I.
, Wang, L.
(2021).
Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions.
Journal of Psychiatric Research, 140, 30-34.
https://doi.
org/10.
1016/j.
jpsychires.
2021.
05.
061 Source: Research by Wang Li, Key Laboratory of Mental Health, Chinese Academy of Sciences Group Lee Gen
