-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Working memory is a system for short-term storage and manipulation of information, supporting cognitive functions such as learning, decision-making, and language understanding
.
The multiplexing buffer model believes that the content of working memory is characterized by different gamma oscillations generated by the synchronous discharge of neuron groups, and these gamma oscillations are locked on a specific phase of the low-frequency oscillation
.
Consistent with the assumptions of this model, previous studies have found that when multiple objects are encoded at the same time, hippocampal gamma activity becomes stronger as the working memory load increases
.
The hippocampal gamma oscillation not only supports working memory, but also participates in the processing of memory accuracy
.
However, previous studies have found that directly stimulating the hippocampus will destroy the memory function, and the network function can be adjusted by stimulating the key nodes in the functional network
.
The anterior nucleus of thalamus (ANT) is located in the upper reaches of the hippocampus and is closely related to the hippocampus
.
Animal studies have found that disrupting the flow of information between the hippocampus and the prethalamic nucleus can impair the performance of spatial working memory
.
Is it possible to regulate the performance of working memory by electrically stimulating the human ANT brain area? To explore this issue, Wang Liang's research group at the Key Laboratory of Mental Health of the Chinese Academy of Sciences and Xuanwu Hospital of Capital Medical University launched a collaborative study
.
The study took 8 patients with temporal lobe epilepsy as subjects.
The subjects were required to complete the classic color recall task of measuring the accuracy of working memory
.
In half of the randomly selected trials, the subjects’ anterior thalamic nucleus received electrical stimulation for 1 second (Figure 1)
.
The behavioral results show that the subjects' working memory accuracy will be significantly improved for the trials of receiving electrical stimulation (Figure 2)
.
The electrophysiological analysis of the hippocampus found that in the trials of receiving electrical stimulation, the gamma activity of the hippocampus was significantly enhanced before the stimulation, the encoding stage, and the extraction stage.
Among them, the hippocampal gamma activity changes and behaviors were significantly improved before the stimulation and the extraction stage.
Related (Figure 3)
.
These results provide direct evidence for the involvement of the human hippocampus-prethalamic nucleus loop in the precision processing of working memory
.
The research results have been published in Brain Stimulation
.
The research was funded by the National Natural Science Foundation of China, the Strategic Leading Science and Technology Project of the Chinese Academy of Sciences (Category B), and the Cross-Innovation Team Project of the Chinese Academy of Sciences
.
Figure 1 Behavioral paradigm diagram: Two color blocks appear on the screen in turn, and then a number appears.
The number 1 prompts the participant to remember the first color, and the number two prompts the participant to remember the second color
.
After a short delay, the subjects needed to use the mouse to click on the color to be memorized in the color circle that appeared afterwards
.
Figure 2 Behavioral results: A.
The working memory accuracy of electrical stimulation trials is significantly improved (the lower the Recall SD is, the higher the working memory accuracy is); B The percentage of each subject's working memory accuracy is improved.
Figure 3 Electrophysiological results: A Prethalamic nucleus electrode Schematic diagram: 1 second to 0.
2 seconds before B stimulation, there are electrical stimulation attempts, hippocampal gamma activity is significantly enhanced; C before stimulation, the increase in hippocampal gamma is significantly related to the improvement of behavior; D all subjects hippocampal electrode distribution diagram; E extraction In the stage, there are electrical stimulation attempts, the hippocampal gamma activity is significantly enhanced; the increase in hippocampal gamma in the F extraction stage is significantly related to the improvement of behavior.
Source: Institute of Psychology, Chinese Academy of Sciences
.
The multiplexing buffer model believes that the content of working memory is characterized by different gamma oscillations generated by the synchronous discharge of neuron groups, and these gamma oscillations are locked on a specific phase of the low-frequency oscillation
.
Consistent with the assumptions of this model, previous studies have found that when multiple objects are encoded at the same time, hippocampal gamma activity becomes stronger as the working memory load increases
.
The hippocampal gamma oscillation not only supports working memory, but also participates in the processing of memory accuracy
.
However, previous studies have found that directly stimulating the hippocampus will destroy the memory function, and the network function can be adjusted by stimulating the key nodes in the functional network
.
The anterior nucleus of thalamus (ANT) is located in the upper reaches of the hippocampus and is closely related to the hippocampus
.
Animal studies have found that disrupting the flow of information between the hippocampus and the prethalamic nucleus can impair the performance of spatial working memory
.
Is it possible to regulate the performance of working memory by electrically stimulating the human ANT brain area? To explore this issue, Wang Liang's research group at the Key Laboratory of Mental Health of the Chinese Academy of Sciences and Xuanwu Hospital of Capital Medical University launched a collaborative study
.
The study took 8 patients with temporal lobe epilepsy as subjects.
The subjects were required to complete the classic color recall task of measuring the accuracy of working memory
.
In half of the randomly selected trials, the subjects’ anterior thalamic nucleus received electrical stimulation for 1 second (Figure 1)
.
The behavioral results show that the subjects' working memory accuracy will be significantly improved for the trials of receiving electrical stimulation (Figure 2)
.
The electrophysiological analysis of the hippocampus found that in the trials of receiving electrical stimulation, the gamma activity of the hippocampus was significantly enhanced before the stimulation, the encoding stage, and the extraction stage.
Among them, the hippocampal gamma activity changes and behaviors were significantly improved before the stimulation and the extraction stage.
Related (Figure 3)
.
These results provide direct evidence for the involvement of the human hippocampus-prethalamic nucleus loop in the precision processing of working memory
.
The research results have been published in Brain Stimulation
.
The research was funded by the National Natural Science Foundation of China, the Strategic Leading Science and Technology Project of the Chinese Academy of Sciences (Category B), and the Cross-Innovation Team Project of the Chinese Academy of Sciences
.
Figure 1 Behavioral paradigm diagram: Two color blocks appear on the screen in turn, and then a number appears.
The number 1 prompts the participant to remember the first color, and the number two prompts the participant to remember the second color
.
After a short delay, the subjects needed to use the mouse to click on the color to be memorized in the color circle that appeared afterwards
.
Figure 2 Behavioral results: A.
The working memory accuracy of electrical stimulation trials is significantly improved (the lower the Recall SD is, the higher the working memory accuracy is); B The percentage of each subject's working memory accuracy is improved.
Figure 3 Electrophysiological results: A Prethalamic nucleus electrode Schematic diagram: 1 second to 0.
2 seconds before B stimulation, there are electrical stimulation attempts, hippocampal gamma activity is significantly enhanced; C before stimulation, the increase in hippocampal gamma is significantly related to the improvement of behavior; D all subjects hippocampal electrode distribution diagram; E extraction In the stage, there are electrical stimulation attempts, the hippocampal gamma activity is significantly enhanced; the increase in hippocampal gamma in the F extraction stage is significantly related to the improvement of behavior.
Source: Institute of Psychology, Chinese Academy of Sciences
