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As the oldest sister journal of Cell, Neuron is one of the most influential and trustworthy journals in the field of neuroscience.
It publishes interdisciplinary research, covering biophysics, cell, development and molecular methods and sensory, motor and high-level A systematic approach to cognitive function
.
Neuron has an impact factor of 17.
173 in 2020, which still maintains a growth rate of 19.
1%.
Let's review the outstanding highly cited papers that Neuron has in 2020! 10.
Dopamine-induced synaptic regulation in the nucleus accumbens of the brain requires astrocyte activity dopamine to participate in physiological processes such as learning and memory, motor control and reward, as well as pathological conditions such as Parkinson's syndrome and addiction
.
Compared with the extensive research related to neurons, the dopaminergic signal transmission involved in astrocytes is still largely unknown
.
This study by the Alfonso Araque team at the University of Minnesota in the United States used genetically modified mice, optogenetics and pharmacogenetics to explore the role of astrocytes in the dopaminergic system
.
Studies have shown that in free-behaving mice, dopamine released from synapses can increase Ca2+ in astrocytes in the nucleus accumbens.
This phenomenon is enhanced by amphetamine stimulation.
The nucleus accumbens is The key reward center in the brain
.
In brain slices, dopamine released from synapses increases Ca2+ in astrocytes, stimulates ATP/adenosine release, and inhibits excitatory synaptic transmission by activating presynaptic A1 receptors
.
Amphetamines inhibit nerve conduction by stimulating astrocytes and subsequent activation of A1 receptors
.
Astrocytes can also modulate the acute behavioral psychomotor effects caused by amphetamines
.
Therefore, astrocytes mediate synaptic regulation caused by dopamine and amphetamine, which reveals a new cellular pathway in the brain's reward system
.
▲
It publishes interdisciplinary research, covering biophysics, cell, development and molecular methods and sensory, motor and high-level A systematic approach to cognitive function
.
Neuron has an impact factor of 17.
173 in 2020, which still maintains a growth rate of 19.
1%.
Let's review the outstanding highly cited papers that Neuron has in 2020! 10.
Dopamine-induced synaptic regulation in the nucleus accumbens of the brain requires astrocyte activity dopamine to participate in physiological processes such as learning and memory, motor control and reward, as well as pathological conditions such as Parkinson's syndrome and addiction
.
Compared with the extensive research related to neurons, the dopaminergic signal transmission involved in astrocytes is still largely unknown
.
This study by the Alfonso Araque team at the University of Minnesota in the United States used genetically modified mice, optogenetics and pharmacogenetics to explore the role of astrocytes in the dopaminergic system
.
Studies have shown that in free-behaving mice, dopamine released from synapses can increase Ca2+ in astrocytes in the nucleus accumbens.
This phenomenon is enhanced by amphetamine stimulation.
The nucleus accumbens is The key reward center in the brain
.
In brain slices, dopamine released from synapses increases Ca2+ in astrocytes, stimulates ATP/adenosine release, and inhibits excitatory synaptic transmission by activating presynaptic A1 receptors
.
Amphetamines inhibit nerve conduction by stimulating astrocytes and subsequent activation of A1 receptors
.
Astrocytes can also modulate the acute behavioral psychomotor effects caused by amphetamines
.
Therefore, astrocytes mediate synaptic regulation caused by dopamine and amphetamine, which reveals a new cellular pathway in the brain's reward system
.
▲
