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NEJM: Should patients with depression in primary care maintain or stop antidepressants?
Time of Update: 2021-10-09
ScreeningIt can be seen that among the patients who felt good in primary care practice and stopped antidepressant treatment, those who were assigned to the discontinuation group had a higher risk of recurrence of depression at 52 weeks than those who were assigned maintenance treatment .
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Stroke: Baseline perfusion imaging to predict the growth rate of stroke infarction
Time of Update: 2021-10-09
It can be seen that the researchers verified a deep learning-based method, which improves the final infarct volume estimation compared with the classic computed tomography perfusion imaging examination .
The researchers verified a deep learning-based method that improved the final infarct volume estimation compared with the classic computed tomography perfusion imaging examination .
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JAMA Neurol: Can the anti-epileptic drug Levetiracetam improve mild cognitive impairment in Alzheimer's disease?
Time of Update: 2021-10-09
Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity: A Randomized Clinical Trial.
BL, the SS Nagarajan, Kirsch HE Effect of Levetiracetam oN Cognition of Alzheimer Disease in Patients With and Without Epileptiform With the Activity: A Randomized Clinical Trial.
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JNNP: GBA gene mutation affects the cognitive status of patients with amyotrophic lateral sclerosis
Time of Update: 2021-10-09
Cognitive phenotype frequency of GBA risk variant carriersA GBA mutation known to cause Gaucher disease in homozygous carriers, a possible pathogenic variant (p.
In summary, this article found that GBA gene mutations are associated with an increased risk of cognitive impairment in ALS patients .
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Stroke: After stroke, thrombolytic therapy, antiplatelet therapy, whether to improve the prognosis
Time of Update: 2021-10-09
After IVT, recent meta-analysis reports show that the risk of antiplatelet-related symptomatic intracerebral hemorrhage (sICH) is higher, but in previous APT users, the rate of favorable functional outcomes and early recanalization has increased .
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Neurology: How does long-term cognitive and movement disorders change in relapsing-remitting multiple sclerosis?
Time of Update: 2021-10-09
Using computerized tests to monitor cognition in clinical practice may find the trajectory of cognitive changes and patients with relapsing-remitting multiple sclerosis who are at risk of disability progression .
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Stroke: How does blood pressure 6 hours after stroke affect the prognosis?
Time of Update: 2021-10-09
Two observational studies found that peak systolic blood pressure (SBP) within 24 hours after stroke was associated with increased risk of symptomatic intracranial hemorrhage (sICH) and functional dependence .
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Neurology: Attention, physical examination found "lacunar infarction", the risk of stroke in the future will increase exponentially!
Time of Update: 2021-10-09
It was first described by scholars about 50 years ago, including occult cerebral infarction (SBI) and white matter degeneration (WMD), occult stroke ( SCD is a type of stroke with only imaging manifestations and lack of neurolocalization signs.
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Neurology: 20 years of follow-up, what factors affect the risk of stroke
Time of Update: 2021-10-09
Data from our long-term population-based stroke study in southern Texas showed that from 2000 to 2010, both Mexican Americans (MAs) and non-Hispanic whites (NHWs) experienced a decline in ischemic stroke rates.
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JNNP: predictors of short-term impulsivity and compulsive behavior in patients with Parkinson's disease after receiving hypothalamic stimulation
Time of Update: 2021-10-09
The subthalamic nucleus (STN) deep brain stimulation (DBS) is a mature treatment method for patients with advanced Parkinson's disease (PD), which can improve the quality of life, sports and non-motor symptoms (NMS) .
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Neurology: Don't just know about dementia, MCI before dementia is preventable and treatable, and it is more worthy of attention!
Time of Update: 2021-10-09
In order to distinguish MCI into meaningful cognitive subtypes based on experience, experts in neurology apply actuarial methods to comprehensive neuropsychological data from the Alzheimer's Disease Research Center (ADRC) of the University of California, San Diego, to determine ADRC participation There is no cognitive subgroup of dementia among the patients, and the trajectories of cognition, biomarkers and neuropathology are studied .
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Neurology: The neuropsychiatric and cognitive symptoms of Alzheimer’s patients may be more common than we thought
Time of Update: 2021-10-09
In order to study the prevalence of neuropsychiatric symptoms (NPS) and the trajectory of the relationship with cognitive function in the β-amyloid positive (A+) population in the clinical spectrum of Alzheimer's disease (AD) .
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Prevent stroke, eat peanuts?
Time of Update: 2021-10-02
At the beginning of the study, basic health information such as age, gender, height, and weight of the subjects were counted; family history and treatment history information of chronic diseases such as hypertension and diabetes; and smoking status, alcohol consumption, and physical activity, including peanuts Information on the consumption and frequency of 138 kinds of food and beverages .
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JAMA Neurol︱Attention!
Time of Update: 2021-10-02
Source︱Chinese Science Fiction, a master editor of scientific visualization︱Logic Neuroscience Dementia is not a natural or inevitable result of aging. Dementia is a disease state in which the cogni
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Sci Adv︱ important discovery!
Time of Update: 2021-10-02
On August 25, 2021, the joint team of Professor Yuan Zengqiang from the Academy of Military Medical Sciences and Associate Professor Cheng Jinbo from Minzu University of China published a research paper entitled "Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology" online in Science Advances, revealing The important role of Calhm2 in the activation of microglia, and provides a potential therapeutic target for targeting microglia-mediated neuroinflammation-related diseases including AD .
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How does the Cell pain receptor TRPV1 perceive a variety of natural stimuli?
Time of Update: 2021-10-02
Under conditions, with the help of single-particle cryo-electron microscopy, a series of intermediate state conformations and activation mechanisms of the capsaicin receptor TRPV1 were analyzed, and a variety of closed and open states were observed, revealing the coupling of multiple ligand interaction sites.
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Trends in Cognitive Sciences Editor's Pick: 12 best reviews of 2020
Time of Update: 2021-10-02
This collection includes reviews and opinion articles, reflecting the breadth of the field of cognitive science .
This collection includes the most downloaded and cited articles of Trends in Cognitive Sciences in 2020, as well as some editorial recommendations .
Interested in publishing your review article in Trends in Cognitive Sciences?
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Sci Adv Jiemin Weng/Xuekun Li team work together to reveal the molecular mechanism of neurodegenerative diseases caused by DNMT1 mutations
Time of Update: 2021-10-02
Responsible editor | Zyme DNA methylation in mammals is an important epigenetic modification, which has the function of regulating gene activity, and plays an important role in embryonic development
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Nature Sub-Journal: Microglia extend the "foot" to Langfei's knot to promote myelin regeneration
Time of Update: 2021-10-02
This indicates that neuronal activity can regulate the dynamic contact between microglia and Langfei junction .
Blocking the potassium ion channel will also reduce the dynamic contact between microglia and Langfei junction .
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Neuron Sheng Zuhang's team focuses on a new mechanism of energy metabolism in the central nervous system: revealing the transcellular transmission pathway of metabolic signals between oligodendrocytes and neuron axons
Time of Update: 2021-10-02
This study reveals for the first time that oligodendrocytes release exosomes to transduce the deacetylase SIRT2 into mature neuron axons, regulate the acetylation level of the axon mitochondrial protein ANT1/2, and then affect axons The biological process of internal energy metabolism .
