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    Home > Active Ingredient News > Study of Nervous System > JAMA Neurol︱Attention!

    JAMA Neurol︱Attention!

    • Last Update: 2021-10-02
    • Source: Internet
    • Author: User
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    Source︱Chinese Science Fiction, a master editor of scientific visualization︱Logic Neuroscience Dementia is not a natural or inevitable result of aging.
    Dementia is a disease state in which the cognitive function of the brain is impaired.
    It will bring memories , Daily living ability, accustomed skills, correct social skills and overall obstacles to the ability to control emotional reactions
    .

    In people's perception, it occurs more frequently in the elderly, but in fact, the prevalence of young people cannot be underestimated
    .

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    Data statistics/typesetting design/three-dimensional modeling/image processing SPSS/GraphPad/3ds Max/Ps/Ai/ImageJ various software comprehensive special training to make your article better a district! There is always a course suitable for your specific course introduction.
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    # free trial lesson video#01 According to the data of Alzheimer’s Disease International Organization, this disease has affected 5000 worldwide Ten thousand people, an average of new cases of dementia appear every 3 seconds
    .

    Dementia has become an increasingly serious public health and social problem
    .

    The World Health Organization predicts that the world’s elderly population will reach 2.
    02 billion in 2050, of which China’s elderly population will reach 480 million, accounting for almost a quarter of the global elderly population
    .

    At this stage, China has the largest number of patients with Alzheimer's disease in the world, and it is also one of the fastest growing countries/regions in the world
    .

    According to statistics, there are currently more than 10 million people suffering from dementia in China, and 60% of them are Alzheimer's disease
    .

    The incidence rate for people over 65 years old is 5%, and the incidence rate for people over 80 years old is more than 30%
    .

    Moreover, "Alzheimer's disease" is no longer the "patent" of the elderly, and it continues to be younger.
    The number of people diagnosed with dementia at the age of 40 or 50 is also increasing year by year
    .

    According to survey data, in large cities such as Tianjin, Shanghai, and Guangzhou, the average age of patients with Alzheimer's disease has advanced from 65 to 55 years old in the past 20 years, and is 10 years younger
    .

    Experts explain that this may be related to diet, stress, and environmental pollution.
    Heavy drinking can affect the brain; and prolonged stress may also lead to early appearance of Alzheimer's
    .

    In addition, patients with hypertension and dyslipidemia are getting younger and younger, which also leads to the advancement of dementia to a certain extent
    .

    02 Early-onset dementia refers to dementia that occurs in adults aged 18-65
    .

    Some scholars further subdivided the cases and attributed cases with onset age between 18-45 years to youth-onset dementia (YOD)
    .

    In order to comprehensively assess the global prevalence of YOD, experts from the Department of Psychiatry and Neuropsychology, Maastricht University Limburg School of Neuroscience, the Netherlands, conducted a meta-analysis, and the results were published in the Journal of the American Medical Association.
    Published in JAMA neurology
    .

    Researchers systematically searched the population-based studies on the prevalence of YOD published between January 1, 1990 and March 31, 2020 in PubMed, Embase, CINAHL, and PsycInfo databases
    .

    Two researchers screened studies containing data on the prevalence of dementia in people under 65 years of age for inclusion in a systematic review and meta-analysis
    .

    This systematic review included a total of 95 unique studies, of which 74 and 2,760,379 unique patients were also included in the 5-year-old meta-analysis
    .

    Most of the research was conducted in elderly populations in Europe and Asia, North America and Oceania
    .

    The age-standardized prevalence is estimated to increase from 1.
    1 per 100,000 people in the 30-34 year old group to 77.
    4 per 100,000 people in the 60-64 year old group
    .

    This makes the global age-standardized prevalence rate of 119.
    0 per 100,000 people between 30 and 64 years old, which is equivalent to 3.
    9 million people in the world suffering from YOD between 30 and 64 years old
    .

    03 For a long time, people have known that Alzheimer's disease caused Alzheimer's disease is a symptom that appears after the age of 60
    .

    In fact, 5%-6% of Alzheimer's disease appears before the age of 65, and many young people with dementia develop symptoms when they are 30-60 years old
    .

    For most Alzheimer's patients, the first symptom that attracts attention may be memory decline, but for young patients, usually before memory declines, their condition may already be very serious
    .

    This is because the diagnosis and treatment of progressive cognitive dysfunction in young people is different from that of older adults
    .

    In particular, the scope of differential diagnosis of the former is much wider, and more extensive evaluation is usually required
    .

    For example, in young patients with posterior cortical atrophy, their first symptoms may be visual problems, such as dyslexia or difficulty in judging distance; in patients with low aphasia, the initial symptom may be language difficulties, which cannot be found.
    There is a long interval between the appropriate words and speech; some patients may have executive or behavioral problems, such as difficulties in planning or making decisions, and unreasonable social performance
    .

    A study published by the University of Miami compared the genetic characteristics of 95 early-onset Alzheimer’s and 7046 late-onset Alzheimer’s and found that 98% of early-onset Alzheimer’s between 45-64 Haimer's disease is caused by mutations in the disease-causing gene carried in the patient's body
    .

    In other words, genes are the main cause of early-onset Alzheimer's disease
    .

    In addition, family medical history, diabetes, depression, head injury, thyroid function decline, stroke, cardiovascular disease, etc.
    are also factors that cause early-onset Alzheimer's disease
    .

    People can prevent early-onset dementia based on the pathogenic factors, such as reducing stress levels, improving nutritional status, losing weight, preventing diabetes, reducing depression levels, quitting smoking and alcohol
    .

    In addition, develop good work and rest habits, try not to stay up late, and ensure 7-9 hours of adequate sleep, so that the brain can fully clean up the junk toxins in the brain, which is also a kind of protection for the brain
    .

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    Do you have any of the following confusions in advanced thematic training? 1.
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     2Course content ★ Chapter 1 ★ SPSS software basics-the initial understanding of the software is not a mistake ▲Using biomedical data as a practical teaching case, explain the various functions of SPSS through practical operations, and learn the software layout and common functions
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    ★Chapter 5 ★Experimental Design Ideas-Designing Experiments without Confusing ▲ Grasp the concept and meaning of experimental design, be familiar with the characteristics and classification of statistical methods, understand the concept, meaning, application conditions and calculation methods of sample content estimation
    .

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    .

    ▲Different statistical methods are selected according to the purpose and type of experiment
    .

    High-end journal application examples Nat.
    Commun.
    2021, 12, 560.
    The epithelial expression of Gata4 and Sox2 regulates the technical specifications of mouse squamous-columnar junctions through MAPK/ERK signaling.
    Developmental Cell 2018, 47(6), 1-17.
    ARP3 Controls the podocyte structure at the kidney filtration barrier Nat.
    Commun.
    2015, 6, 8835.
    Endothelial Gata5 transcription factor regulates blood pressure Gut 2017, 66 (9), 1665-1676 GATA6 regulates EMT and tumor spread, and marks the response to adjuvant chemotherapy in pancreatic cancer Nucleic Acids Research 2019, 47(19), 10104-10114.
    Molecular determinants of enzalutamide-induced transcription in prostate cancer Annals of the Rheumatic Diseases 2018, 77, 1226-1233.
    Metabolic pathways and immune metabolism of rare kidney diseases 2 Statistical analysis, graphic layout and image processing training As a leading professional scientific research visualization company in China, China Science Fiction has a design team composed of hundreds of masters and doctors, with a deep scientific research background + professional design standards = 300 + significantly improved through statistical analysis Article-level cases + more than 3,000 papers with pictures for more than 1,000 research groups every year + more than 600 training sessions for more than 7,000 students in the first seven years of the course
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    2Course Content Part1 Statistical Analysis of Experimental Data Chapter 1 GraphPad Statistics and Making Data Charts ♦Learn the basics of statistics commonly used in biomedicine, understand the software layout, statistical ideas and common skills of GraphPad
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    ♦ Learn the basics of statistics, basic data processing, master normal distribution, single / two-tailed test, assuming that concept and so on
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    Before performing statistical analysis, learn to test the requirements and applicable conditions of the data, perform the homogeneity of variance test, the normality test, etc.
    , as well as the processing methods when the variance is not uniform
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    Choose appropriate treatment methods for different situations, and learn statistical analysis methods such as T test, analysis of variance, and chi-square test
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    ♦ Use GraphPad to perform linear regression analysis, use regression equations for output analysis and processing, draw scatter plots, perform residual analysis, and draw corresponding regression curves
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    ♦Drawing exquisite statistical graphs GraphPad-easy drawing of advanced graphs
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    Learn the principles of graph drawing, and master various statistical methods and their associated statistical charts
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    Learn a variety of GraphPad table operations, from data import, software practical operation, statistical graph generation, graph adjustment, color matching to image export
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    ♦Use GraphPad to make different types of data charts, such as: heat map (gene analysis or protein expression), bubble chart, volcano chart, survival curve chart, XY chart, histogram, pie chart, scatter chart, line chart, contingency chart Tables, etc.
    , understand the concepts of survival analysis, and perform survival time calculations
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    ♦Combine the data chart expression and presentation skills in high-end literature, export the GraphPad chart vector, open it in other software and further beautify it
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    According to different data, combined with actual problems, choose different statistical methods, summarize and summarize the applicable conditions of each method, and no longer worry about which method should be used for statistics
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    Learning software: "GraphPad prism 8" Part2 Path diagram/pattern diagram/mechanism diagram drawing & a large number of image data typesetting skills Chapter 2 Basic knowledge and skills of drawing vector graphics ♦ The difference between vector graphics and bitmaps, which software can be convenient and quick Of drawing scientific research graphics
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    Understand the common techniques of color circle and color matching
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    Learning software: "Adobe illustrator" Chapter 4 Typesetting Skills for Large-scale Image/Chart Data ♦Analyze the typesetting rules of image and chart type data sets in articles published in high-end journals, compare different cases, and analyze the typesetting ideas in different situations
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    Such as: photo, immunofluorescent, FIG pathology, flow diagram, like FIG strip
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    As: XY, histogram, heat, scatter, line, contingency table, survival graph, pie chart and the like
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    Learning software: "Ai/Photoshop Comprehensive Application" Part3 Experimental Image Processing Chapter 5 Basic Knowledge of Scientific Research Maps and Image Data ♦Analyze the importance of papers matching images in high-end scientific research articles, and understand what abilities are required to produce pictures of the same level , What software needs to be mastered
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    ♦Understand the concept of images, understand different forms of data expression, master basic knowledge of layout, resolution, format (tiff/gif/jpg/png), white balance, grayscale, color mode (RGB/CMYK/HSB/Lab), etc.

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    ♦Learn the processing ideas of data images, statistical charts, drawing graphics and typesetting, and compare the advantages and uses of each software when encountering different needs
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    Chapter 6 Submission Image Standards and Image Processing Specifications ♦ Interpret the relevant requirements of international journals for images, grasp the preferences of various journals for submission of images, and learn how to improve the quality of the images to make the article easier to stand out
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    ♦Understand the different manifestations of images in high-end articles, and learn different types of performance skills
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    ♦ Learn the basic principles and specifications of image processing in scientific research; how to make data more convincing while complying with the principles of scientific ethics, understand what is strictly prohibited, and make data processing worry-free
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    Learn to master cell scratch area analysis, how to view the histogram, remove the background, and count gray values
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    Learning software: "ImageJ" Chapter 8 Experimental Data Image Beautification Processing Skills ♦Immunohistochemistry stitching, image grouping or batch processing of multiple images
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    ♦Color the electron microscope photos and adjust the white balance
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    to repair the image, and cut out methods in different situations
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    Learning software: "Photoshop" 2 lecturer team 4 course benefits After registration, you can participate in any other sessions of this course in the country for unlimited times, and you will be provided with the necessary software download and installation, a large number of SPSS statistical supporting practice cases and reference materials, and SPSS after-school reference books.
    With the commonly used drawing material package, professional lecturers in the exchange group of students after class answer questions and guide at any time
    .

    SPSS Graphpad PhotoshopAdobe illustrator ImageJ "required software and material package download and installation" "SPSS after-school reference book and common drawing material package" "after-class student exchange group lecturer at any time to answer questions and guide" 5 training site 6 registration method SPSS statistical basics and advanced Special Training October 9-10, 2021 Beijing·Institute of Physics, Chinese Academy of Sciences October 23-24, 2021 Shanghai·Fudan University Original price: 3199 yuan/person group Quote: 2999 yuan/person (3 people and above) Registration consultation: 18410111600 (WeChat same number) The specific meeting location is subject to email notification (for more sessions, please scan the QR code above, and the sessions in the form will be updated in real time) Note: Scan the QR code to fill in the registration form online, and the staff will receive the registration information The first time you call to confirm the relevant information
    .

    If there is any abnormality in the form registration, please contact the teaching assistant 18410111600 (same number on WeChat).
    Training schedule for statistical analysis, graphic layout and image processing September 17-18, 2021 Beijing·Institute of Physics, Chinese Academy of Sciences September 19-20, 2021 Wuhan· Wuhan University Guangzhou·Jinan University September 27-28, 2021 Hangzhou·Zhejiang University Tianjin·Tianjin University Xi’an·Shaanxi University of Science and Technology October 4-5, 2021 Hefei·University of Science and Technology of China Jinan·University of Jinan Chongqing·Chongqing University 2021 October 11-12, 2010 Shenzhen·Chinese Academy of Sciences Shenzhen Research Institute October 18-19, 2021 Tianjin·Tianjin University Chengdu·Sichuan University October 23-24, 2021 Beijing·Institute of Physics, Chinese Academy of Sciences October 25-26, 2021 Shanghai·Fudan University, Guangzhou·Jinan University November 1-2, 2021 Xi'an·Shaanxi University of Science and Technology Original price: 3296 yuan/group price: 3096 yuan/person (3 people and above) Registration consultation: 18410111600 (same number on WeChat) The meeting location is subject to email notification (for more sessions, please scan the QR code above, and the sessions in the form will be updated in real time) Note: Scan the QR code to fill in the registration form online, and the staff will contact you by phone as soon as the registration information is received Confirm relevant information
    .

    If there is any abnormality in the registration form, please contact the teaching assistant 18410111600 (same number on WeChat).
    Note: If you have special training needs, you can arrange for a lecturer to go to your organization for special training.
    The price of special training is better.
    For more information, please add the course assistant WeChat: wuruixue2910 provides formal The invoice (including the conference registration form, invitation letter and other reimbursement materials), the cost includes two days of lunch, accommodation and other expenses are at your own expense
    .

    After registration, a staff member will contact the trainees to confirm relevant information, and the specific meeting location will be notified by email
    .

    The staff will send the actual course address, software required for the course, and download and installation tutorials to the students’ mailbox on the Wednesday of the last week before the start of the course
    .
    Students are requested to check their emails at that time .

    The veteran students will not repeat the arrangement of lunch and materials for re-listing.
    Please contact the course assistant (WeChat: 18410111600) in advance to sign up, and bring your ID card to sign in on the spot
    .

    Payment method ▷ Bank transfer and remittance (received by Jinan branch) Receiving unit: Beijing China Science Fantasy Animation Technology Co.
    , Ltd.
    Jinan Branch Bank Account Number: 15126701040003321 Account Bank: Agricultural Bank of China Co.
    , Ltd.
    Jinan Chacheng Branch Remarks: Name + Unit + session ▷ Alipay transfer company Alipay account: zhongkehuancaijn@126.
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    , Ltd.
    Jinan Branch Remarks: name + organization + session For cash or WeChat payment, please scan the QR code to fill in the registration information so that we can prepare invoices and other reimbursement procedures for you in advance
    .

    Due to the limited number of places, in order to ensure that your registration is successful, students who register on-site or fail to receive the public transfer before the start of the class, please pay a deposit of 1,000 yuan at the time of registration, and refund the deposit on the same day after the full payment is received
    .

    7 Frequently Asked Questions Student I am a zero-based student, can I learn it in two days? In order to improve the learning efficiency of students and save travel time, our course schedule is two days, but the course content will be arranged in the morning, afternoon and evening.
    The total teaching time is equivalent to three days of training; our courses are taught by hand to ensure all zeros Basic students can keep up and learn well, and the on-site learning rhythm is gradual to ensure that each student can fully absorb the essence of the course, and our course is to sign up for an unlimited number of listening sessions~ Chinese Science Fiction students, may the learning software have a mac version NS? Every software involved in the training has a mac version that can be downloaded and used, which is completely suitable for Apple laptops~How many students are there in each training of Chinese Science Fiction Students? Isn't it the kind of big class with lots of people? In order to ensure the quality of teaching and create a comfortable learning environment for students, we will limit the number of students enrolled to less than 20 in each training session to ensure a good classroom order.
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    Chinese science fiction student I am a slow student, slow to accept new knowledge, what should I do if I don’t learn enough at one time? We will arrange multiple training sessions in different cities across the country every month.
    Old students can listen to them for free, and they can go back to school for free for a lifetime.
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    Can Chinese Science Fiction students issue invoices for reimbursement? sure! We will issue formal invoices for trainees, and can provide training invitation letters, project list, conference registration form and other materials according to trainees' reimbursement needs, and issue invoices and reimbursement materials to trainees on the day of training
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    Does China Science Fiction Student Training provide board and lodging? We provide students with two-day training lunches.
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    Science Fiction Color 3 Scientific Research Drawing·Academic Image Special Training Specific course introduction, please click on the picture link ##Scientific animation production Imagine that if you brush the literature in the future, it will only take a minute or less like a short video.
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    Liu Yunqi, an academician of the Chinese Academy of Sciences, used chemical vapor deposition to synthesize nitrogen-doped graphene and studied its electrical properties.
    He found that nitrogen doping can effectively affect the graphene’s properties.
    Electrical properties have greatly promoted the research and application of graphene
    .

    Produced by China Science Fiction, broadcast by Beijing Satellite TV, a Chinese female scientist from the University of New South Wales, Hao Xiaojing, won the Australian Prime Minister's Science Award in 2020
    .

    China Science Fiction has been commissioned by him to produce an animation of personal scientific research achievements for Mr.
    Hao Xiaojing.
    In the past ten years, Xiaojing Hao’s team has been committed to the research and development of new thin-film batteries, setting four world records for solar cell efficiency, and has become the world’s leading solar thin-film battery scientific research.
    Forerunner, China Science Fiction assists scientists in the visual display and promotion of scientific achievements
    .

    The team of Academician Zhang Guangjun of Beijing University of Aeronautics and Astronautics of China Science Fiction Co.
    , Ltd.
    has developed a series of test equipment of three types of dynamic test stations for train operating conditions, filling the gap in China, and its main performance indicators have reached or surpassed foreign mainstream products, meeting the urgent needs of China's railway transportation
    .

    The NuProbe Global team took the lead in developing a unique and novel PCR-based enrichment method-Blocker Displacement Amplification (BDA)
    .

    BDA technology can selectively amplify low-abundance sequence variants (SNV and indels) in the background of wild-type DNA
    .

    China Science Fiction was commissioned by Yueer Gene Company to produce a demonstration animation of scientific principles for this technology to help the company's core technology display and promotion
    .

    China Science Fiction Production Major Academic Conference Propaganda Sino Science Fiction was commissioned by the organizer of the Chinese Academy of Engineering to produce a webpage opening animation for the 2020 International Conference on Innovation and Emerging Industry Development (IEID)
    .

    The homepage display animation produced by China Science Fiction for the official website of the conference.
    Important academic conference report.
    Academician Wang Zhonglin, an internationally recognized leader in the field of nanotechnology, delivered a speech on friction nano generators at the Chinese Academy of Sciences Gezhi Forum.
    China Science Fiction produced scientific research results for it.
    The demonstration video of the principle of Wang Zhonglin adds luster to this technology with a valuation of 1 billion U.
    S.
    dollars
    .

    The animation of academician Wang Zhonglin’s speech is played live.
    The first issue of the open-access journal SusMat, co-founded by China Science Fiction, the dynamic cover design Wiley and Sichuan University, is officially launched.
    As one of the members of the "Mat" series of high-end journals under Wiley, the cover of the first issue of SusMat is the first to use the cover The dynamic cover is about to lead a new wave of scientific visual expression
    .

    Among them, the design and production of the SusMat journal LOGO and the two dynamic covers are all completed by China Science Fiction
    .

    Susmat’s two dynamic covers are both produced by China Science Fiction.
    The text description is very clumsy in front of the animation presentation.
    More and more top publications are beginning to introduce the expression of video abstract (Video Abstract), which is vivid.
    The scientific videos made the expression of scientific research results no longer obscure, and allowed more ordinary people outside the academic circle to reach the cutting-edge core of science, providing a more powerful way for the dissemination of scientific results
    .

    China Science Fiction Production, China Science Fiction Production, is the guide video "The Most Complete Explanation of the New Crown Vaccine", the production principle, animation hits over one million, China Science Fiction Production, China Science Fiction Production Animation works have appeared on CCTV news broadcast seven times and ten times Go to Science/Nature magazine.
    We have a professional scientific animation design team to provide you with professional design services.
    For more animation works in science fiction production, please visit https://space.
    bilibili.
    com/487058367 Animation and PPT business consultation Ms.
    Li 17686795308 (WeChat same number) We will arrange professional project managers to come to communicate and negotiate.
    Remarks: For other services such as scientific research, drawing design and training, please consult Rui Xue 17686689807 (WeChat same number) Scan the QR code below to reply "I want to listen" to get a free trial course Video Beijing China Science Fiction Animation Technology Co.
    , Ltd.
    Thesis illustration cover design, scientific animation, scientific research drawing training, SPSS training, finite element simulation training, statistical analysis, graphic layout and image processing training, special training, PPT beautification, promotional video http: // Hengxing Building, No.
    89 Zhongguancun East Road, Haidian District, Beijing.
    ︱Wang Sizhen End of this article
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