Stroke: After stroke, thrombolytic therapy, antiplatelet therapy, whether to improve the prognosis

Endovascular therapy (EVT), whether prior to intravenous thrombolysis (IVT) or not, is the most effective method for the treatment of patients with acute ischemic stroke (AIS) caused by anterior circulatory occlusion (LVO)

Timely and successful recanalization is the most critical determinant of functional recovery after EVT, and it can be achieved in more than 70% of patients

First, the microvascular reperfusion of the veins and arteries is incomplete, which is observed in approximately one-quarter of patients who successfully recanalize, leading to unfavorable brain tissue results

Antiplatelet therapy (APT), such as aspirin, may improve the quality of recanalization after EVT and restore microvascular reperfusion, but one of its main disadvantages is that it may increase the risk of hemorrhagic transition

Recent data in the EVT era still support the uncertainty of the efficacy and safety of APT patients.

Adjusted for the following factors: age, NIHSS score, early CT score of the Alberta stroke program, intravenous thrombolysis, time from onset to puncture) and meaningful baseline differences between groups

They analyzed a total of 2939 patients, of which 877 (29.

Complete reperfusion rate (37.

Symptomatic intracerebral hemorrhage (aOR, 0.

The important significance of this study lies in the discovery: APT performed in advance does not affect the angiography and functional results after endovascular treatment, and acute vascular reconstruction strategies should not be considered