-
Express delivery of more than 70% of patients without recurrence within 4 years, and the new drug for multiple sclerosis has a positive long-term effect
Time of Update: 2021-10-21
▎Bristol-Myers Squibb (BMS), editor of WuXi AppTec's content team, announced today that the S1P receptor modulator Zeposia (ozanimod) has achieved positive results in a phase 3 clinical extension trial for the treatment of patients with relapsing multiple sclerosis (MS) .
-
The relationship between patent foramen ovale and migraine, dizziness and vestibular migraine, this article explains very clearly
Time of Update: 2021-10-21
Judging from the current research, whether it is the relationship between PFO and migraine or with vertigo or VM, most studies are still focused on clinical research.
No Relationship Between Patent Foramen Ovale and Migraine Frequency.
-
In the same two developed countries, different choices brought about completely different endings!
Time of Update: 2021-10-21
Recently, a report published in JAMA Neurology entitled "Comparison of treatment strategies from 2 different countries: Relapsing-remitting multiple sclerosis (RRMS) patients The real-world study of "Upgrading Treatment vs.
The results of this study also show that for patients with RRMS, early and high-efficiency treatment of DMTs is more effective than upgrading treatment.
-
Nature Hong Weizhe's team reveals the neural coding mechanism of prosocial behavior
Time of Update: 2021-10-21
This work conducted an in-depth study of prosocial behavior in mice and revealed important neurobiological mechanisms in the brain that encode and control this behavior .
-
The results of the Phase III study of FcRn antagonists are gratifying, and patients with systemic myasthenia gravis usher in a new gospel!
Time of Update: 2021-10-21
In June this year, the international authoritative medical journal "The Lancet Neurology" published the results of a phase III clinical study of neonatal Fc receptor (FcRn) antagonist efgartigimod, showing that it has a good effect on the treatment of adult systemic MG (gMG) And safety, which is of great significance to patients .
-
Why do we need comfort when Nature's experiment failed?
Time of Update: 2021-10-21
In conclusion, the study showed that mice exhibited pro-social comforting behavior and revealed a neural circuit mechanism that is the basis for the coding and control of affinity touch during pro-social interaction .
-
Oxford scientists discovered: laxative can also pass memory, this drug may create the "most powerful brain"
Time of Update: 2021-10-21
In this experiment, compared with the placebo group, the procapride group had a significantly increased response to familiar images in the right corner gyrus .
-
[Cell] Scientists at Harvard University have discovered a mechanism that helps explain why certain parts of the body are so sensitive to external perceptions
Time of Update: 2021-10-21
Recently, scientists at Harvard Medical School discovered a mechanism in a new study they led that could help They recognize what causes some skin areas to be more sensitive .
-
Some parts of your body are too sensitive?
Time of Update: 2021-10-21
▲When the glabrous area (adult) is touched, the neuron signals in a specific brain area will be stronger, which is in sharp contrast with the hairy area (picture source: reference [2]) but the brain The stem is also eccentric, and brainstem neurons will have a stronger connection with sensory neurons in the hairless area, amplifying the signs of sensitive skin .
-
To identify key pathogenic proteins in Alzheimer's disease, Harvard scientists develop important detection tools
Time of Update: 2021-10-21
. Recently, scientists have developed a sensitive detection method specifically designed to identify and quantify Aβ oligomers in the human brain, cerebrospinal fluid, and blood .
-
New mechanism of Mol Cell︱ Alzheimer's disease: Tau protein oligomerization induces nuclear cell transport of RNA binding protein HNRNPA2B1 and mediates enhancement of m6A-RNA modification
Time of Update: 2021-10-21
On August 27, 2021, in the latest paper published online in Molecular Cell with the title "Interaction of Tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of Tauopathy", Lulu Jiang of Boston University, USA ( Article 1), Benjamin Wolozin (corresponding author) and others have studied these scientific issues .
-
Ischemic stroke with atrial fibrillation: timing of anticoagulation, treatment strategies... 5 hot issues addressed in one article
Time of Update: 2021-10-21
The following are major recommendations: 2021 American Heart Association (AHA)/American Stroke Association (ASA) recommendation: For patients with ischemic stroke or TIA combined with non-valvular atrial fibrillation, if there is no moderate to severe mitral stenosis or mechanical For valves, NOAC (apixaban, dabigatran, edoxaban, rivaroxaban) is recommended to be superior to warfarin to reduce stroke recurrence .
-
Neuron Mao Dun et al. reveal the spatial representation characteristics of the hippocampus of freely moving macaques
Time of Update: 2021-10-21
Traditional analysis methods have shown that neuronal activity in the hippocampus of rhesus monkeys presents selective specific firing activities (ie tuning characteristics) for a variety of spatial information, including horizontal position, horizontal head orientation, translational speed, etc.
-
Express uses B cells to cross the blood-brain barrier to deliver protein drugs, and US$900 million helps develop new cell therapies
Time of Update: 2021-10-21
▎ WuXi AppTec content team editor October 13, 2021, Immusoft announced that it has signed a research cooperation and licensing option agreement with Takeda, which will use Immusoft’s immune system programming ISP technology platform to discover, develop and commercialize Transformative cell therapy for the treatment of rare genetic metabolic disorders .
-
Nature breakthrough!
Time of Update: 2021-10-21
In 2020, the Harvard Medical School Professor Ma Qiufu’s team published in Neuron’s research results, revealing that low-intensity acupuncture to stimulate acupoints on the hind limbs of mice (such as Zusanli ST36) can activate the vagus nerve-adrenal anti-inflammatory pathway, while acupuncture stimulates acupuncture points on the abdomen (such as ST36).
-
Novartis DRAGON study yielded positive results, confirming the effectiveness and safety of Erenumab in preventing chronic migraine in adults
Time of Update: 2021-10-21
The DRAGON study has confirmed that Erenumab can significantly reduce the number of migraine days per month for the main chronic migraine population in China (MMD), the safety tolerance is similar to placebo .
-
Historic breakthrough: Acupuncture and moxibustion research appears on Nature, and Harvard Chinese scholars provide modern neuroanatomical basis for the existence of acupoints
Time of Update: 2021-10-21
In 2020, a research paper published by Professor Ma Qiufu's team at Harvard Medical School in Neuron [1] revealed that low-intensity acupuncture to stimulate acupoints on the hind limbs of mice (such as Zusanli ST36) can activate the vagus nerve-adrenal anti-inflammatory pathway, while acupuncture stimulates acupoints on the abdomen (Such as Tianshu ST25) but cannot induce this anti-inflammatory pathway .
-
Mol Cell Liu Sanxiong et al. reveal the mechanism by which non-classical PRC1 activates transcription and participates in brain development
Time of Update: 2021-10-21
On October 11, 2021, the New York University School of Medicine/Howard Hughes Institute of Medicine Danny Reinberg Laboratory (first author is Liu Sanxiong) published an online article titled "NRF1 association with AUTS2" in Molecular Cell magazine.
-
It is the main cause of death and disability among Chinese residents!
Time of Update: 2021-10-21
According to the data of the "China Death Cause Monitoring Data Collection 2019", cerebrovascular diseases, malignant tumors, and heart disease are among the top three mortality rates in the Chinese population, and men are higher than men.
-
Cereb Cortex transcription-neuroimaging association analysis reveals the genetic mechanism of resting state functional connectivity in human visual cortex subregions
Time of Update: 2021-10-21
Figure 2 Functional enrichment results of genes related to occipital visual subregion rsFC (picture quoted from: Cun Zhang, et al.
, Cerebral Cortex, 2021; bhab335) Figure 3 Specificity of genes related to occipital visual subregion rsFC Expression analysis results (picture quoted from: Cun Zhang, et al.
