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As we all know, many mental illnesses are often accompanied by cognitive dysfunction.
Cognitive impairment is not limited to memory deficits, but also includes obstacles in learning, attention, language, and processing speed
.
Such disorders can have a considerable negative impact on the quality of life, so there is an urgent need to develop treatments that can improve cognitive deficits associated with mental illness
.
In animal studies, because 5-HT4 receptor agonists can enhance hippocampal-dependent memory processes, 5-HT4 receptors can be used as a potential therapeutic target for cognitive disorders
.
However, due to safety considerations, it is currently difficult to translate these animal research results into human research
.
Recently, researchers from the University of Oxford in the United Kingdom have taken a different approach and explored the potential of 5-HT4 receptor agonist products that have been approved for marketing in the treatment of cognitive impairment
.
They found a drug Prucalopride to treat constipation, which not only has good brain penetration, but if taken under medical supervision, the product can significantly improve the patient’s cognitive level while avoiding serious Side effects issues
.
Relevant research results are titled "Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task" and published in the sub-Journal "Translation Psychiatry" of "Nature"
.
https://#Abs1 In this study, there were 44 healthy participants between the ages of 18 and 36.
The researchers asked the participants to complete self-report questionnaire to obtain a baseline measurement data on mood, anxiety, etc.
.
They were then randomly divided into groups, and they were given either procapride or placebo for 7 days
.
On the 6th day of taking procapride, the participants underwent a functional magnetic resonance scan (fMRI) and completed a series of memory tasks designed to induce the activation of the hippocampus
.
In the task, the researchers showed participants 4 animal images and 4 landscape images that were similar in complexity and brightness
.
The randomly selected images appeared on the screen 8 times in a pseudo-random order, and participants were asked to respond with two different buttons to identify animal and non-animal images
.
In this pre-scan task, both the placebo group and the prucalopride group recognized images with an accuracy of more than 95%, and there was no significant difference
.
In the subsequent post-scanning recall task, the use of procapride led to an improvement in memory.
Compared with the accuracy rate of 75.
67% in the placebo group, the accuracy of image recognition in the procapride group was higher, reaching 81.
04%
.
Legend: In the post-scan task, compared with the placebo group, the procapride group was more accurate in recognizing images.
The researchers found that it was consistent with the memory improvement seen at the behavioral level, and compared with the placebo group.
Procapride activates the hippocampus region of the human body and increases the subject’s memory of the two encoded images
.
Although memory function is not specific to a certain brain region, the hippocampus plays an important role in it, especially when it involves rich mental images, and it is closely related to memory regions including the angular gyrus
.
Clinically, angular gyrus lesions can cause language dysfunction, low mood and poor memory
.
Previous studies have shown that in patients with mild cognitive impairment, compared with healthy controls, in resting state fMRI, the activity of the right corner gyrus is significantly reduced
.
In this experiment, compared with the placebo group, the procapride group had a significantly increased response to familiar images in the right corner gyrus
.
This shows that the increased activity of the right corner gyrus after procapride administration also promoted the improvement of subjects' cognitive ability
.
Legend: The response of the procapride group to the familiar image increased in the right corner gyrus area.
Therefore, from the experiments of the above researchers, it can be seen that compared with placebo, the subjects' hippocampus and hippocampus after 6 days of treatment with placebo Neural activity in related functional areas is enhanced, and memory ability is improved
.
In conclusion, this study shows that, consistent with previous animal studies, as a 5-HT4 receptor agonist, procapride's cognitive effect is very obvious, and it is useful for future use of 5-HT4 receptor agonists.
It brings hope to improve the cognitive impairment related to mental illness
.
Future research work also needs to further optimize the dosage of procapride to ensure maximum effectiveness while minimizing side effects
.
In addition, accurately describing which specific cognitive areas can benefit from 5-HT4 receptor agonists to achieve precise targeting of cognitive deficits is also an important step in achieving effective treatment
.
In order to facilitate you to continue to receive our articles, you are welcome to set us as a "star" so that you can see our news in the future
.
End reference materials: [1]https://#Abs1
Cognitive impairment is not limited to memory deficits, but also includes obstacles in learning, attention, language, and processing speed
.
Such disorders can have a considerable negative impact on the quality of life, so there is an urgent need to develop treatments that can improve cognitive deficits associated with mental illness
.
In animal studies, because 5-HT4 receptor agonists can enhance hippocampal-dependent memory processes, 5-HT4 receptors can be used as a potential therapeutic target for cognitive disorders
.
However, due to safety considerations, it is currently difficult to translate these animal research results into human research
.
Recently, researchers from the University of Oxford in the United Kingdom have taken a different approach and explored the potential of 5-HT4 receptor agonist products that have been approved for marketing in the treatment of cognitive impairment
.
They found a drug Prucalopride to treat constipation, which not only has good brain penetration, but if taken under medical supervision, the product can significantly improve the patient’s cognitive level while avoiding serious Side effects issues
.
Relevant research results are titled "Déjà-vu? Neural and behavioural effects of the 5-HT4 receptor agonist, prucalopride, in a hippocampal-dependent memory task" and published in the sub-Journal "Translation Psychiatry" of "Nature"
.
https://#Abs1 In this study, there were 44 healthy participants between the ages of 18 and 36.
The researchers asked the participants to complete self-report questionnaire to obtain a baseline measurement data on mood, anxiety, etc.
.
They were then randomly divided into groups, and they were given either procapride or placebo for 7 days
.
On the 6th day of taking procapride, the participants underwent a functional magnetic resonance scan (fMRI) and completed a series of memory tasks designed to induce the activation of the hippocampus
.
In the task, the researchers showed participants 4 animal images and 4 landscape images that were similar in complexity and brightness
.
The randomly selected images appeared on the screen 8 times in a pseudo-random order, and participants were asked to respond with two different buttons to identify animal and non-animal images
.
In this pre-scan task, both the placebo group and the prucalopride group recognized images with an accuracy of more than 95%, and there was no significant difference
.
In the subsequent post-scanning recall task, the use of procapride led to an improvement in memory.
Compared with the accuracy rate of 75.
67% in the placebo group, the accuracy of image recognition in the procapride group was higher, reaching 81.
04%
.
Legend: In the post-scan task, compared with the placebo group, the procapride group was more accurate in recognizing images.
The researchers found that it was consistent with the memory improvement seen at the behavioral level, and compared with the placebo group.
Procapride activates the hippocampus region of the human body and increases the subject’s memory of the two encoded images
.
Although memory function is not specific to a certain brain region, the hippocampus plays an important role in it, especially when it involves rich mental images, and it is closely related to memory regions including the angular gyrus
.
Clinically, angular gyrus lesions can cause language dysfunction, low mood and poor memory
.
Previous studies have shown that in patients with mild cognitive impairment, compared with healthy controls, in resting state fMRI, the activity of the right corner gyrus is significantly reduced
.
In this experiment, compared with the placebo group, the procapride group had a significantly increased response to familiar images in the right corner gyrus
.
This shows that the increased activity of the right corner gyrus after procapride administration also promoted the improvement of subjects' cognitive ability
.
Legend: The response of the procapride group to the familiar image increased in the right corner gyrus area.
Therefore, from the experiments of the above researchers, it can be seen that compared with placebo, the subjects' hippocampus and hippocampus after 6 days of treatment with placebo Neural activity in related functional areas is enhanced, and memory ability is improved
.
In conclusion, this study shows that, consistent with previous animal studies, as a 5-HT4 receptor agonist, procapride's cognitive effect is very obvious, and it is useful for future use of 5-HT4 receptor agonists.
It brings hope to improve the cognitive impairment related to mental illness
.
Future research work also needs to further optimize the dosage of procapride to ensure maximum effectiveness while minimizing side effects
.
In addition, accurately describing which specific cognitive areas can benefit from 5-HT4 receptor agonists to achieve precise targeting of cognitive deficits is also an important step in achieving effective treatment
.
In order to facilitate you to continue to receive our articles, you are welcome to set us as a "star" so that you can see our news in the future
.
End reference materials: [1]https://#Abs1
