-
One article clarifies: the diagnosis and treatment strategy for embolic stroke of unknown cause!
Time of Update: 2021-10-21
Source of ESUS emboli: cardiogenic Professor Chen Huisheng introduced that cardiogenic factors mainly include 4 types, namely cryptogenic atrial fibrillation, atrial heart disease, undiagnosed myocardial infarction, and patent foramen ovale .
-
Mol Cell Liu Sanxiong et al. reveal the mechanism by which non-classical PRC1 activates transcription and participates in brain development
Time of Update: 2021-10-21
On October 11, 2021, the New York University School of Medicine/Howard Hughes Institute of Medicine Danny Reinberg Laboratory (first author is Liu Sanxiong) published an online article titled "NRF1 association with AUTS2" in Molecular Cell magazine.
-
Reduce the intravenous thrombolysis time of cerebral infarction, this combination is too powerful!
Time of Update: 2021-10-21
Figure 5: Modified Rankin score at 90 days▎ Conclusion: For patients with acute ischemic stroke who meet the criteria for tissue plasminogen thrombolysis, MSU treatment is better than EMS in terms of patient prognosis .
-
Tau protein misfolded this week's "Nature" cover story
Time of Update: 2021-10-21
Subsequently, the researchers used these different folds to determine the hierarchical classification of tau protein diseases based on structure .
-
How much do you know about intracranial hemorrhage associated with dual antiplatelet therapy?
Time of Update: 2021-10-21
The PEGASUS-TIMI 54 trial showed that for patients with a history of subacute myocardial infarction (1-3 years), compared with aspirin monotherapy, patients who received extended DAPT therapy (median 33 months) had a higher risk of ICH .
-
It is the main cause of death and disability among Chinese residents!
Time of Update: 2021-10-21
According to the data of the "China Death Cause Monitoring Data Collection 2019", cerebrovascular diseases, malignant tumors, and heart disease are among the top three mortality rates in the Chinese population, and men are higher than men.
-
Elife: The winner effect and social status may affect the ability to resist stress
Time of Update: 2021-10-21
In another non-social chronic stress model, stress does not change the existing social hierarchy of mice, and only causes social disorders in disadvantaged mice .
This shows that the previous winner effect may and may affect the predictability of social hierarchy to stress response .
-
Cereb Cortex transcription-neuroimaging association analysis reveals the genetic mechanism of resting state functional connectivity in human visual cortex subregions
Time of Update: 2021-10-21
Figure 2 Functional enrichment results of genes related to occipital visual subregion rsFC (picture quoted from: Cun Zhang, et al.
, Cerebral Cortex, 2021; bhab335) Figure 3 Specificity of genes related to occipital visual subregion rsFC Expression analysis results (picture quoted from: Cun Zhang, et al.
-
Courier can treat Alzheimer's disease by putting a "plaster" every week, and the innovative medication method is expected to be approved next spring
Time of Update: 2021-10-21
▎ WuXi AppTec content team editor On October 12, 2021, Corium announced that the US FDA has set the new drug application (NDA) PDUFA target date for its donepezil (donepezil) transdermal patch Adlarity as March 11, 2022.
-
Is intravenous thrombolysis safe for patients with ischemic stroke with saccular aneurysm?
Time of Update: 2021-10-21
In order to evaluate whether IVT treatment of AIS can cause UIA rupture and intracranial hemorrhage (ICH) in patients with unruptured UIA, Jyri Virta, MD, from the Department of Neurology, University of Helsinki, Finland, conducted a study.
-
The Lancet: Anticancer drug axitinib becomes a new hope for Alzheimer's disease
Time of Update: 2021-10-21
The study used the anticancer drug Axitinib (a small molecule tyrosine kinase inhibitor that targets the vascular endothelial growth factor receptor) to target the pro-angiogenic pathway of Alzheimer's disease, significantly reducing cerebral angiogenesis , Restored the integrity of the blood-brain barrier, reduced β-amyloid protein deposition, and effectively restored the memory and cognitive abilities of Alzheimer's disease mice .
-
Alzheimer's & Dementia Fractal Patterns of Daily Activities and Alzheimer's Disease or Dementia
Time of Update: 2021-10-21
Ju team of the Center worked together to study the relationship between the pathological parameters of Alzheimer's disease in vivo (including PiB amyloid and cerebrospinal fluid tau) and the fractal pattern of motion signals (article 2) .
-
ARNI hypertension indication is approved, and blood pressure management of patients in Shennei ushered in a new mechanism drug!
Time of Update: 2021-10-21
On September 15 and September 29, under the auspices of Professor Liu Liping, Beijing Tiantan Hospital, Capital Medical University, and Professor Pan Suyue, Nanfang Hospital of Southern Medical University, many experts in the field of internal medicine focused on the antihypertensive needs of patients with internal medicine and the development of existing drugs.
-
Guideline consensus: Evidence-based medicine guidelines for the treatment of motor symptoms in middle and late stages of Parkinson's disease in China
Time of Update: 2021-10-20
When the optimal drug treatment still fails to improve the symptom fluctuation or the effect is not satisfactory, DBS surgery can be considered (level A recommendation) .
-
Annals of Neurology: The elderly have difficulty finding words, which may be related to tau protein
Time of Update: 2021-10-20
Tau began to deposit in the medial temporal lobe in the form of neurofibrillary tangles in middle age, which is about the same time as people begin to experience memory retrieval difficulties .
-
JAMA N: What is the best screening method for thrombectomy patients?
Time of Update: 2021-10-20
The DEFUSE 3 study used a short treatment interval (6-16 hours) and used MRI or CTP scans to select patients with mismatched target perfusions .
Assessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset: A Pooled Analysis of the AURORA Database .
-
Interpretation of schizophrenia case
Time of Update: 2021-10-20
diagnosisJune 2019: My condition is stable, my final exam is not good (second year), I didn't suspend school, during treatment, I would fall asleep after taking medicine .
Efficacy evaluation: After 3 weeks of treatment, the patient's hallucinations have been significantly improved, and he no longer sees his boyfriend .
-
Stroke: Stroke treatment, time is life
Time of Update: 2021-10-20
Compared with the historical control group (n=187), EVT patients in the SSTS group (n=244) were older and had a higher baseline NIHSS:During SSTS, the median time from onset to puncture was 136 minutes, vs.
-
NEJM: Efficacy of intranasal oxytocin treatment in children and adolescents with autism spectrum disorder
Time of Update: 2021-10-20
This placebo-controlled trial of intranasal oxytocin treatment in children and adolescents with autism spectrum disorder showed that the least squares average change in social or cognitive function indicators was not significant compared to baseline over a 24-week period The difference between groups .
-
JAHA: The effect of peripheral microvascular endothelial dysfunction on white matter hyperintensity
Time of Update: 2021-10-20
Peripheral endothelial dysfunction is associated with the increase in the volume of paracortical WMH in patients over 50 years of age, which is a potential marker for predicting the risk of IS in the future .
