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September Neurology Guidelines and Consensus, one article is included in the guide consensus
Time of Update: 2021-10-22
The Neuro-Intervention Professional Committee of the Chinese Medical Doctor Association organizes relevant experts to combine the current research status at home and abroad and China's clinical practice, repeatedly discussing and reaching an expert consensus on ICAS imaging evaluation, aiming to provide for the clinical diagnosis and treatment of ICAS Provide references and suggestions .
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Express for the treatment of Alzheimer's disease, Genentech's anti-amyloid antibody therapy was approved by the FDA as a breakthrough therapy
Time of Update: 2021-10-22
▎The content team editor of WuXi AppTec today, Genentech, a subsidiary of Roche, announced that the US FDA has granted an anti-β-amyloid antibody therapy gantenerumab breakthrough therapy designation for the treatment of Alzheimer’s disease (AD ) .
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Professor Wang Qun: 2021 Severe EEG Monitoring Terminology Update!
Time of Update: 2021-10-22
At the 24th National Neurology Conference of the Chinese Medical Association in September 2021, Professor Wang Qun from Beijing Tiantan Hospital, Capital Medical University, shared with us the update of the American Society of Clinical Neurophysiology (ACNS) this year 2021 Second Edition Standard Terminology for Severe EEG Monitoring, and gave a detailed introduction and interpretation of the important updated content.
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Neuron Yang Guangyu's team develops artificial neural network to simulate the brain to recognize odors
Time of Update: 2021-10-22
The brain's olfactory circuit has been most accurately mapped in Drosophila: starting from the antennae, each sensory neuron is equipped with a receptor that detects a specific odor .
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The Lancet: Stroke may become the world’s “number one killer” in health
Time of Update: 2021-10-22
In summary, the study shows that from 1990 to 2019, although the age-standardized rate dropped sharply, especially among the elderly over 70, the number of deaths caused by strokes and strokes continued to increase sharply each year .
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"Save the coma movement", save the "vegetable"
Time of Update: 2021-10-22
Focusing on the content of consciousness recovery, at the 24th National Neurology Conference of the Chinese Medical Association, Professor Pan Suyue from the Nanfang Hospital of Southern Medical University, starting from the implicit cognition of chronic consciousness disorders, further introduced " "Save the Coma Campaign", brought a wonderful report .
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Challenge the classics!
Time of Update: 2021-10-21
The researchers used a variety of tools in mice to specifically knock out BDNF on astrocytes and inhibit the formation of late LTP.
Subsequent experiments confirmed that neuron-derived BDNF is critical for the formation of early and late LTP .
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Intracranial aortic occlusive cerebral infarction, from the cause to the prognosis, is a clinical necessity!
Time of Update: 2021-10-21
Figure 3 Machine learning methods (picture from Professor Liu Xiaoyun's PPT) The research of Professor Liu's team shows that occlusion of blood vessels, hyperhomocysteinemia, age, diabetes, and atrial fibrillation are the top 5 AIS in patients with AC-LVO Independent risk factors .
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Sub-Journal of Nature: The answer to Alzheimer's disease has already appeared?
Time of Update: 2021-10-21
The team of researcher Huang Yadong from the Gladstone Institute found that a powerful fast-acting diuretic, bumetanide, which has been on the market for more than 30 years, successfully reversed AD-related transcriptome characteristics in mouse and human neurons in experiments, and AD-related manifestations.
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"Old medicine" reduces the risk of Alzheimer's disease by 35-75%, "Nature" magazine reveals new strategies for therapeutic development
Time of Update: 2021-10-21
▲The treatment of bumetanide (right) reduces the deposition level of amyloid in Alzheimer's disease mouse model (picture source: reference [2]) Traditional drug development is after animal research, usually in human clinical The safety of the drug is tested in detail in the trial.
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Courier blood test to diagnose Alzheimer's disease, innovative test was recognized by FDA as a breakthrough medical device
Time of Update: 2021-10-21
▎Editor of WuXi AppTec's content team On October 12, 2021, Quanterix announced that its blood test Simoa phospho-Tau 181 (pTau-181) has been granted a breakthrough medical device designation by the US FDA to assist in the diagnosis of Alzheimer's Disease (AD) .
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Alzheimer's disease is still related to the liver?
Time of Update: 2021-10-21
The researchers observed through the tracer that the Aβ produced in the liver of HSHA mice was carried by lipoproteins rich in triglycerides and entered the brain from the periphery through the blood .
3001358[2] Protein from the liver may cause Alzheimer's disease in the brain.
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The primary prevention of ischemic stroke starts from these two aspects!
Time of Update: 2021-10-21
The active participation of primary general practitioners in comprehensive prevention and treatment is one of the key measures to control ischemic stroke .
Guidelines for Primary Diagnosis and Treatment of Ischemic Stroke (Practical Edition·2021)[J] .
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Oxygen inhalation improves memory?
Time of Update: 2021-10-21
The test results show that after hyperbaric oxygen treatment, elderly patients who have suffered from memory loss or partial loss have shown an improvement in cerebral blood flow and an effective increase in cognitive ability .
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The latest research: Can't you skip thrombolysis before mechanical thrombus removal after stroke?
Time of Update: 2021-10-21
This study [3] predicts the risk of rupture of growing intracranial aneurysms .
They were excluded from the visit, and 312 patients with intracranial aneurysm growth were finally included .
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NCN 2021 ｜Interview with Professor Lu Jiahong and Yang Huan: Diagnosis points, treatment dilemmas and new hopes of myasthenia gravis
Time of Update: 2021-10-21
Professor Yang Huan said that the results of the ADAPT study showed that compared with the placebo group, efgartigimod treatment of adult systemic MG patients can effectively improve their clinical symptoms and quality of life, and is well tolerated .
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5 new types of anti-epileptic drugs, one article to master!
Time of Update: 2021-10-21
Randomized double-blind clinical controlled trial: Included in 6 countries, 38 centers, 199 patients with confirmed Dravet [baseline seizure frequency more than 4 times comprehensive Tonic-clonic seizures (GTCS)/4 weeks, monotherapy failure]; 10mg and 20mg/kg/d group cannabidiol oral add-on treatment, similar to the reduction of seizure frequency, the 10mg group is better than the 20mg group in safety and tolerability ; The addition of cannabidiol exceeds 10mg/kg/d, and individualized effectiveness and safety should be weighed .
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For the prevention and treatment of acute ischemic stroke complications in the acute phase, see expert guidance!
Time of Update: 2021-10-21
④For patients with malignant middle cerebral artery infarction and severe intracranial pressure increase within 48 hours of onset and under 60 years of age, the condition is still aggravated by active drug treatment, especially for patients with lowered level of consciousness, please consult neurosurgery to consider whether to reduce it.
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After a lapse of 11 years, the European Society of Neurology/Peripheral Neurology has updated its guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy!
Time of Update: 2021-10-21
➤For patients suspected of typical CIDP, because they meet the clinical criteria but do not meet the minimum electrophysiological diagnostic criteria, if they are objectively improved after receiving IVIg, corticosteroids or plasma exchange treatment, and if there is at least one additional support standard, they can Diagnosed as possible typical CIDP .
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"The prosperous husband and the poor, the happy extreme is the sad"-the role of the hypothalamus in food rewards and drug rewards
Time of Update: 2021-10-21
For food and entertainment activities, they are somewhere between natural rewards and drug rewards, but as pressure increases and time passes, they may also have a certain chance to develop into uncontrollable "addiction" .
