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Nature reveals the development of interneurons in the cerebral cortex
Time of Update: 2021-10-22
(References can be read by sliding ) Reprint Instructions [Original Articles] BioArt original articles, personal reposting and sharing are welcome, reprinting is prohibited without permission, the copyright of all published works is owned by BioArtSingle-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation.
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Nature publishes 16 papers in a row, deciphering the mystery of the human brain
Time of Update: 2021-10-22
Francis Collins (left) October 7, 2021, Nature launched 16 "BRAIN Initiative" research papers at one time, reporting the phased research results of this ambitious project-at the molecular level Fully map the characteristics of mammalian primary motor cortex cell types .
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JCI: Improve the metabolism of macrophages and repair damaged nerves
Time of Update: 2021-10-22
The study, by selectively knocking out and overexpressing MCT1 in macrophages, found that MCT1 contributes to the metabolism, phenotype and function of macrophages and supports peripheral nerve regeneration, proving that regulating macrophage metabolism can promote peripheral nerve damage Recovery .
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Lipids and Alzheimer's disease!
Time of Update: 2021-10-22
, Found that the loss of myelin sulfatide in the central nervous system (CNS) in adulthood is sufficient to activate disease-related microglia and astrocytes, increasing multiple AD risk genes and confirmed AD-related The expression of key regulators of immune/microglia regulation ultimately leads to AD-like chronic neuroinflammation and mild cognitive impairment .
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"Electric shock" treats Parkinson's disease, "Science" publishes a new breakthrough!
Time of Update: 2021-10-22
In the Parkinson's disease model mice, the improved new deep brain stimulation method is used to provide the treatment effect for a longer duration than the traditional method, which is 4.
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Cancer Discovery Significant progress!
Time of Update: 2021-10-22
A research paper on "Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells", which explores genes in a large number of patient-derived GSCs, differentiated glioblastoma cells (DGC) and neural stem cells (NSC) Expression and genome-wide CRISPR/Cas9 screening to determine the main regulators of GSC stemness, revealing that the basic transcription status increases with RNA polymerase II-mediated transcription .
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A new index for CTP assessment when making decisions about thrombus removal in acute ischemic stroke, 5 minutes to understand
Time of Update: 2021-10-22
3) CTP is used as a new indicator of AIS: The remaining rescue organization time is based on the linear growth of core infarction .
1. For patients with acute anterior circulation and great vessel occlusion stroke, the core volume growth rate may have guiding significance for decision-making .
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Cereb Cortex Li Tao's group reported the abnormality of the cortical myelin covariation network with the deep characteristics of the cerebral cortex in schizophrenia
Time of Update: 2021-10-22
In general, this study proposes to introduce depth information into the study of cortical myelin sheath, and use the method of structural covariation for network recognition and analysis, which provides a new perspective for the imaging study of brain abnormalities in schizophrenia .
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Science Bulletin Nanchang University Professor Pan Bingxing's research group reveals the important loop molecular mechanism of chronic stress-induced excessive anxiety
Time of Update: 2021-10-22
In conclusion, this study shows that chronic stress can selectively reduce the GABAA(δ)R-mediated tonic inhibitory current in BLA→vHPC neurons, thereby down-regulating the ability of GABA to inhibit the activity of these neurons, causing mice to produce Excessive anxiety-like behavior .
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It's too hard for young people...New research points out that depression when you are young is more prone to dementia in old age
Time of Update: 2021-10-22
Researchers at the University of California, San Francisco (UCSF) have found that depression in youth may accelerate the rate of cognitive decline and increase the risk of dementia in the future .
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Nature back-to-back expert reviews!
Time of Update: 2021-10-22
The gene deletion in mice indicates that retinoic acid signals through retinoic acid receptors RXRG and RARB and CYP26B1-dependent catabolism are involved in the appropriate molecular patterns of the prefrontal lobe and motor area, the development of the PFC-medial thalamic connection, and the dendrites in the PFC The fourth layer marks the occurrence and expression of RORB spines .
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Exercise-related molecule irisin improves cognitive function
Time of Update: 2021-10-22
Comment This study confirmed that the hormone irisin produced during exercise can improve the cognitive function of healthy mice and Alzheimer's disease-like mice .
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New Nobel Prize winner’s latest Cell paper: Cheng Yifan/David Julius collaborated to reveal how the pain receptor TRPV1 perceives a variety of natural stimuli
Time of Update: 2021-10-22
Source | Xiaoke Life Structure Biology is well-known to help understand the occurrence and development mechanism of macroscopic phenomena from the molecular level, especially due to the increasing ma
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The potential mechanism of stromal cells in predicting the prognosis of glioma
Time of Update: 2021-10-22
Abbreviations: GASC, glioma-associated stromal cell TCGA, The Cancer Genome Atlas CGGA, Chinese Glioma Genome Atlas HGG, high-grade glioma; High-grade glioma ssGSEA , Single-sample Gene Set Enrichment Analysis algorithm PCA, Principle Component Analysis DEGs, differentially expressed genes; CNV, copy number variations; ICPs, immune checkpoints.
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New progress in early endovascular treatment of acute ischemic stroke, mastering 6 aspects in one article
Time of Update: 2021-10-22
▌ The DIRECT-MT study of Changhai Hospital of Naval Military Medical University compares the efficacy of thrombus removal combined with or without intravenous thrombolysis in the treatment of acute ischemic stroke, a multicenter randomized controlled trial (RCT) .
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[Science] How to better understand the connection details of 86 billion neurons in the brain?
Time of Update: 2021-10-22
They published this discovery in an article titled "The glial framework reveals white-matter fiber architecture in human and primate brains" in "Science" magazine: Scientists have been using purple Nissel staining for a long time.
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The "double-edged sword" of Dev Cell neurons—Xiao Bo's team reveals a new mechanism by which lactic acid induces peripheral nerve damage
Time of Update: 2021-10-22
On October 6, 2021, a research team led by Professor Xiao Bo from the School of Life Sciences of Southern University of Science and Technology published an article Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability in the Journal of Developmental Cell, and found that peripheral glial cells-Schwann The pyruvate-lactic acid conversion metabolism regulated by Rheb in cells is very important for maintaining the stability of axons in the peripheral nervous system .
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Eat peanuts and become smart?
Time of Update: 2021-10-22
Recently, a study published in Clinical Nutrition suggests that eating peanuts can also have a beneficial effect on the cognitive function and stress response of healthy young people (18-33 years old) .
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Do you know everything about the management of covert cerebrovascular disease?
Time of Update: 2021-10-22
03 In patients with hidden cerebral small vessel disease (WMH and/or lacunar), whether lipid-lowering treatment can reduce ischemic or hemorrhagic stroke, cognitive decline or dementia, dependence, death, MACE, activity or Mood disorder?
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September Neurology Guidelines and Consensus, one article is included in the guide consensus
Time of Update: 2021-10-22
The Neuro-Intervention Professional Committee of the Chinese Medical Doctor Association organizes relevant experts to combine the current research status at home and abroad and China's clinical practice, repeatedly discussing and reaching an expert consensus on ICAS imaging evaluation, aiming to provide for the clinical diagnosis and treatment of ICAS Provide references and suggestions .
