Exercise-related molecule irisin improves cognitive function

This article comes from the NEJM Journal Watch Exercise-Related Molecule Improves Cognitive Function Comment on the cognitive function of the molecule related to exercise.
Author: Anthony L.
Komaroff, MD The hormone irisin produced during exercise can improve the cognition of mice Function
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Regular exercise can improve weight control, prevent type 2 diabetes, and improve cardiovascular health
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But what is the mechanism? In 2012, researchers demonstrated that during exercise, the hormone irisin, which converts white fat cells (storing fat) into brown fat cells (burning fat), and improves insulin resistance (NEJM JW Gen Med Mar 15 2012 and Nature 2012; 481) :463), which suggests the mechanism by which regular exercise has a beneficial effect on the metabolism and cardiovascular system
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Regular exercise can also improve the cognitive function of humans and mice
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Is irisin also a medium to enhance cognitive function? In a new study, researchers demonstrated that after knocking out the gene encoding irisin in mice, regular exercise no longer improves cognitive function, and that the neurons formed in adulthood are abnormal
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After injecting irisin into the hippocampus, cognitive function improved
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After gene therapy was used to restore the ability of mouse liver to produce irisin, the hormone could cross the blood-brain barrier, and the cognitive function of mice was improved
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In two mouse models of Alzheimer’s disease, increasing irisin levels also improved cognitive function.
The mechanism seems to be to reduce neuroinflammation associated with Alzheimer’s disease (NEJM JW Gen Med Jun 15 2020 and Sci Adv 2020; 6:eaay8828)
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Comment This study confirmed that the hormone irisin produced during exercise can improve the cognitive function of healthy mice and Alzheimer's disease-like mice
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This molecule is also produced during human movement
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This discovery may help us develop methods to prevent or treat human cognitive decline
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Commented article Islam MR et al.
Exercise hormone irisin is a critical regulator of cognitive function.
Nat Metab 2021 Aug; 3:1058.
(https://doi.
org/10.
1038/s42255-021-00438-z) NEJM journal collection NEJM Journal Watch is published by NEJM Group.
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