Oxygen inhalation improves memory?

▎The editors of WuXi AppTec’s content team forget the way home, can’t recognize the person in the mirror, can’t say what they want to say.
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About 50 million people worldwide suffer from Alzheimer’s disease (AD) or other related forms Dementia
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Although some therapies can help reduce symptoms and even delay disease progression, there are still many obstacles to the cure and prevention of diseases
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 However, good news keeps coming.
For example, researchers from Israel recently discovered that a new approach that directly targets the root cause of Alzheimer’s disease---Hyperbaric Oxygen Therapy (HBOT) can reverse the relationship between patients and the biological markers of the disease.
Brain damage
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The press release pointed out that this is the first time that non-drug therapies have been proven to be effective in preventing the core biological processes that lead to the development of Alzheimer's disease, bringing light to the path to disease prevention
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 ▲The paper was published in the journal Aging (picture source: screenshot of the paper page) The main corresponding author of the paper, Professor Shai Efrati of Tel Aviv University, Israel, said: “By treating the root cause of patients’ cognitive deterioration with age, We have actually found a way to prevent Alzheimer's disease
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"In recent years, people have discovered that vascular dysfunction is closely related to the pathogenesis of Alzheimer's disease and the decline in cognitive ability during aging
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Vascular dysfunction can lead to a decrease in cerebral blood flow (CBF) and hypoxia.
Cerebral amyloid angiopathy (CAA) is the most common vascular disease in Alzheimer’s disease, which is mainly manifested by β-amyloid protein (aβ) in the walls of cerebral blood vessels.
) Deposition, which is the typical pathological biomarker signal of Alzheimer's disease
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CBF can be detected in the early stages of the disease, so it has become a promising therapeutic target, which is expected to fundamentally prevent and reverse the disease outcome
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 Hyperbaric oxygen therapy is commonly used to treat carbon monoxide poisoning and tissue hypoxia infections, such as burns and diabetic ulcers
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Some previous studies have found that if hyperbaric oxygen therapy is used in a specific way, it can repair damaged brain tissue, restore the growth of blood vessels and nerve cells in the brain, increase cerebral blood flow and improve patients' cognitive function
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Therefore, researchers want to know its potential in the field of Alzheimer's disease
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 ▲The pre-clinical mouse model showed that after AD mice were treated with hyperbaric oxygen therapy, the brain aβ deposition plaques were significantly reduced, the diameter of blood vessels increased, and blood flow increased (picture source: reference [1]).
Trials were conducted in patients over 65 years of age who are usually in the deteriorating stage of mental function in Alzheimer's disease and dementia
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Subjects need to breathe 100% pure oxygen in a high atmospheric pressure cabin where the atmospheric pressure environment is greater than an absolute value of atmospheric pressure (ATA), and undergo 60 treatments for 90 days
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 The test results show that after hyperbaric oxygen treatment, elderly patients who have suffered from memory loss or partial loss have shown an improvement in cerebral blood flow and an effective increase in cognitive ability
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 The specific results of the test are as follows: On average, 16.
5% of patients showed improvement in memory ability
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16%-23% of patients have increased cerebral blood flow
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6% of patients showed improvement in concentration and concentration
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10.
3% of patients improved the speed of information processing ▲Hyperbaric oxygen therapy improved the cerebral blood flow and cognitive function of elderly patients (picture source: reference [1]) The researchers pointed out that this discovery is toward the development of prevention of Alzheimer's An encouraging step in the new approach to Zheimer's disease
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Hyperbaric oxygen therapy not only shows that it can improve the symptoms of patients at the level of disease biomarkers, but also solves the core pathological and biological problems responsible for disease development
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 Dr.
Ronit Shapira, the first author of the paper, commented: "Our findings provide hope that humans can fight Alzheimer's disease
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Based on our findings, giving hyperbaric oxygen therapy at a young age may be expected to completely prevent this serious disease
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”References: [1] Shapira, R.
, et, al.
(2021).
Hyperbaricoxygen therapy alleviates vascular dysfunction and amyloid burden in anAlzheimer's disease mouse model and in elderly patients.
Aging, 13(17),20935–20961.
https ://doi.
org/10.
18632/aging.
203485[2] New non-drug treatment holds promise for preventative therapies for Alzheimer's.
Retrieved September 13, 2021, from https://medicalxpress.
com/news/2021-09-non- drug-treatment-therapies-alzheimer.
html