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Wang Yaning: Hope to eliminate the misunderstanding of aducanumab approval IBIWS
Time of Update: 2021-11-04
✔ According to Dr. Yaning Wang, Bojian’s decision to stop research is wrong . The reason is that the two assumptions on which the decision is based are not valid . ✔ Combining all the data, even i
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Break through common sense!
Time of Update: 2021-11-04
Although the current mainstream theory believes that the root cause of Alzheimer's disease is amyloid deposition, in recent years, the "infection theory" has gradually attracted the attention of the scientific community .
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Summary of AMEM stroke animal model
Time of Update: 2021-11-04
In summary, this article describes in detail the production, advantages and disadvantages of rat stroke models, and elaborates the characteristics of animal models of ischemic and hemorrhagic stroke respectively, which provides a basis for simulating stroke lesions in different disease states .
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The imaging progress of ECTRIMS 2021 MS
Time of Update: 2021-11-04
Adelphi’s real-world MS DSP study showed that in the past 12 months, naSPMS patients (compared to aSPMS) had higher Extended Disability Status Scale (EDSS) scores and received fewer MRI examinations (the proportion of MRI examinations) Lower, and the number of MRI scans done by each person is less) .
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Nat Commun︱ selective inhibition of microglia activation is expected to alleviate the spread of pathological α-syn
Time of Update: 2021-11-04
Therefore, these results prove that PFF induces pro-inflammatory factors released by microglia to up-regulate the expression of α-syn by activating dopaminergic neurons NF-κB, and this process can be effectively inhibited by wtTIDM (Figure 6) .
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Nat Neurosci Li Bo's team discovers a new loop mechanism of punishment and reward behavior in the amygdala
Time of Update: 2021-11-04
Zhang Xian under the guidance of Professor Li Bo conducted a systematic study on neurons expressing the Fezf2 gene in the basolateral amygdala, including In vivo single-photon calcium signal imaging, optogenetics, chemical genetics, physiological response detection, and various behavioral methods have discovered neurons and their downstream neural circuits that encode rewards and punishments respectively .
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Zhang Yongqing's team research found that ApoE gene mutant dogs can effectively simulate human cardiovascular and cerebrovascular diseases
Time of Update: 2021-11-04
Recently, Zhang Yongqing's research team from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, Beijing Sino Valley Biotechnology Company, the team of Professor Ji Xunming of Beijing Xuanwu Hospital, and the team of Professor Liu Enqi of Xi'an Jiaotong University Medical College have jointly published a question in Science China Life Sciences.
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Gene therapy delivered by AAV is expected to cure Angel syndrome
Time of Update: 2021-11-04
The research team used adeno-associated virus (AAV) vector-delivered gene therapy to deliver the therapeutic UBE3A gene to the brain of a mouse model of Angel Syndrome, and successfully repaired its motor deficits, seizures and other neurological symptoms without obvious Side effects .
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No high blood pressure, type 2 diabetes, hyperlipidemia... why repeat cerebral infarction?
Time of Update: 2021-11-04
Previous cerebral infarction for 1 month, left limb weakness, now oral aspirin enteric-coated tablets (100mg qd), clopidogrel bisulfate tablets (75mg qd), atorvastatin calcium tablets (20mg qn) treatment; deny hypertension , Diabetes, hyperlipidemia and other medical history .
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Summary of knowledge points: early recognition and management of acute ischemic stroke
Time of Update: 2021-11-04
Recent studies have shown that early recognition of acute ischemic stroke (AIS), emergency interventional therapy, and treatment in specialized stroke centers can significantly reduce stroke-related morbidity and mortality .
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Physician must: Screening and treatment of asymptomatic carotid artery stenosis
Time of Update: 2021-11-04
3. Patients with asymptomatic carotid artery stenosis (stenosis 60%-99%) and life expectancy greater than 5 years can be treated with CEA in qualified hospitals (hospitals with a perioperative stroke and death rate of less than 3%) ( Class IIa recommendation; Level B evidence).
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The 14th National Conference on Immunology——The Charm of Neuroimmunology
Time of Update: 2021-11-04
Professor Qi Hai’s report on “the role of brain-spleen axis and behavioral regulation of antibody immunity” (photo source: Zhou Xuexun) and Chief Physician Shi Fudong from Beijing Tiantan Hospital/Tianjin General Hospital-Jingjin Neuroimmune Center, for the first time here A conference report on clinical neuroimmunology will be made (Figure 2) .
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Science: Harvard University reveals neurons responsible for social interaction in the brain
Time of Update: 2021-11-04
. By tracking the social interactions between three rhesus monkeys, the study discovered the central role of neurons in the dorsal medial prefrontal cortex of the brain on group behavior, and demonstrated how these neurons can regulate the interaction between members of a specific group, revealing The cellular mechanism that supports the interactive behavior of social groups .
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ECTRIMS 2021 Ofatumumab latest research progress
Time of Update: 2021-11-04
In order to explore the early effects of ofatumumab treatment on microglia activity in patients with RMS, Professor Tarun Singhal and others conducted a 9-month study and released the interim analysis results at the ECTRIMS meeting .
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J Neurosci︱ Junli Cao’s research group reveals the loop mechanism of the anterior cingulate gyrus to regulate mirror pain
Time of Update: 2021-11-04
Figure 4 The effect of repeated inhibition and specific destruction of the pyramidal neurons projecting across the corpus callosum in the CCI contralateral ACC on pain behavior (picture quoted from: Hu et al.
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NEJM: Optogenetics, let blind patients re-perceive light
Time of Update: 2021-11-04
In 2005, Karl Deisseroth and colleagues published a landmark study, which proved that a simple single-molecule microbial opsin can be used as an optogenetic tool [5]: the expression of ChR2 in cultured hippocampal neurons Enables light to trigger action potentials with millisecond precision .
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Neurosci Bull︱Shen Ying's team reveals the three-dimensional heterogeneity of projections from the cerebellar nucleus to the thalamus
Time of Update: 2021-11-04
, Neurosci Bull 2021) Conclusion and discussion of the article, inspiration and prospects To sum up, the study used in vivo electrophysiological recording and trans-synaptic virus tracing experiments The method revealed the three-dimensional spatial heterogeneity of the cerebellar IpN-thalamic VL projection (Figure 5), and IpN only forms a functional connection with the contralateral VL .
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Hemangioma Syndrome, Uremic Encephalopathy, LGI-1 Encephalitis 3 Minute Reading·34 Issue
Time of Update: 2021-11-04
Case 3, a 35-year-old female patient with a normal body, had sudden left limb weakness for 4 days .
Case 13 is a 13-year-old female with left upper limb weakness for one month .
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Can't sleep well or not enough?
Time of Update: 2021-11-04
Only for medical professionals to read and refer to clinical information, 1s to reach more cutting-edge clinical information, pay attention to clinical assistants in the medical community Reliable, but it does not make any promises or guarantees on the timeliness of the published content, and the accuracy and completeness of the cited information (if any), and does not assume that the content is outdated and the cited information may be inaccurate.
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Study the brain mechanism of the influence of fear emotional stimuli on time perception
Time of Update: 2021-11-04
In the latest study, Fu Xiaolan's research group at the State Key Laboratory of Brain and Cognitive Sciences explored the regulatory effects of unpredictable fear emotional stimuli on time perception and its neural mechanisms through EEG technology .
