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Parkinson's disease (PD) is a common degenerative disease of the central nervous system, the main clinical manifestations are tremor, hypoactivity, rigidity, postural balance disorder and other motor symptoms
.
In addition to motor dysfunction, mental disorders such as depression and anxiety of varying degrees are also common, which affect the quality of life, daily functions and prognosis of patients, and have gradually attracted attention in recent years
Parkinson's disease (PD) is a common degenerative disease of the central nervous system, the main clinical manifestations are tremor, hypoactivity, rigidity, postural balance disorder and other motor symptoms
This community-based cohort study included participants in 3 continuous cohorts that were recruited in 1994, 1997, and 2004
.
Before death, the participants were observed for an average of 7.
The main result is that Parkinson's disease is evaluated annually using 26 items in the modified exercise section of the Unified Parkinson's Disease Rating Scale
.
According to the score of the project, a summary score is developed.
The results showed that of the 516 dead, 364 (70.
5%) were women, and the average (SD) age at death was 90.
2 (6.
4) years
.
Higher WMH is associated with faster Parkinson's disease progression (estimated value, 0.
Higher WMH is associated with faster Parkinson's disease progression (estimated value, 0.
White matter connections in Parkinson's patients with or without WMH
In summary, in this cohort study, higher levels of WMH and cerebrovascular disease pathological indexes in the elderly brain are associated with faster Parkinson's disease progression
.
Further research is needed to determine whether brain imaging in the elderly to obtain evidence of WMH and active medical treatment of vascular risk factors and diseases can reduce the occurrence or severity of Parkinson's disease in later life
In summary, in this cohort study, higher levels of WMH and cerebrovascular disease pathological indexes in the elderly brain are associated with faster Parkinson's disease progression
references:
Oveisgharan S, Yu L, Poole VN, et al.
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