Express treatment of Alzheimer's disease, stem cell therapy shows positive potential

▎Editor of WuXi AppTec's content team recently, GABAeron announced active preclinical research data obtained from cell therapy for Alzheimer's disease based on induced pluripotent stem cells (iPSC)
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These data demonstrate the potential of transplanting interneuron progenitor cells derived from human iPSC differentiation in the treatment of Alzheimer's disease and other neurological diseases with interneuron defects or deletions
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Previous studies have shown that people carrying the APOE4 gene have a higher risk of Alzheimer's disease and an earlier age of onset.
About 60-75% of Alzheimer's patients will express APOE4 protein in the brain
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Dr.
Huang Yadong, co-founder of GABAeron Science, discovered an important cause of Alzheimer's disease caused by APOE4: APOE4 can cause damage and loss of GABAergic interneurons in the hippocampus of the brain
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The hippocampus is an important area responsible for our learning and memory, and GABAergic cells are essential for maintaining normal hippocampal activities
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In this study, scientists first successfully induced human iPSCs carrying the APOE3 gene to differentiate into GABAergic interneuron progenitor cells.
The resulting cells showed high viability, purity and powerful functions, and more than 90% were in the correct developmental lineage
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The researchers then transplanted them into the hippocampus of mice (10 months old) carrying the APOE4 gene
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Experimental results show that interneuron progenitor cells exhibit a strong survival rate and mature and differentiate into functional GABAergic interneurons
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Seven months after transplantation, more than half of the surviving cells have migrated out of the local area, filled different sub-regions of the hippocampus, and successfully established connections with other existing neurons in the hippocampus
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▲The poster displayed by GABAeron (picture source: reference [1]) electrophysiological records showed that the hippocampus of mice carrying APOE4 was defective, which may be the basis of memory impairment related to Alzheimer's disease
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After receiving approximately 120,000 APOE3-carrying interneuron progenitor cells for 7 months, the activity of the hippocampus of these mice improved to the level observed in healthy mice
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"If we can replace the missing interneurons through cell therapy, we can restore normal hippocampal activity, thereby slowing or reversing many of the memory and cognitive impairments associated with Alzheimer's disease," Dr.
Huang explained, "if This method is effective, and one treatment may have a long-lasting effect on the patient
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" Dr.
Sheng Ding, co-founder of GABAeron Science commented: "After reaching this critical milestone, GABAeron is more confident about future clinical trials in humans.
Moving forward
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We also plan to explore the effects of cell therapy on other neurological diseases with defective or missing interneurons
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"Reference: [1] GABAeron Presents Promising Preclinical Data on Stem Cell-Based Therapy for Alzheimer's Disease.
Retrieved October 30, 2021, from https:// -data-on-stem-cellbased-therapy-for-alzheimers-disease-301409130.
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