Mol Psychiatry: Stress-related diseases should pay more attention to the family environment

Most people experience some stressful life events or trauma in their lifetime
.

These events increase the risk of serious mental reactions, including post-traumatic stress disorder (PTSD), acute stress response (ASR), and adjustment disorders

Vascular Immunity

Donghao Lu et al .
published a research article in Mol Psychiatry .
They analyzed genetic and early environmental factors to investigate whether parental/perinatal adversity would cause offspring to have a higher risk of stress-related diseases in later life
.

Mol Psychiatry published a research article, through the analysis of genetic and early environmental factors, to investigate whether parental/perinatal adversity will cause offspring to have a higher risk of stress-related diseases in later life
.

The study conducted a population-based cohort study based on Swedish national registration data.
The subjects were 3,435,747 single births (2,554,235 were brothers and sisters)
.

A population and sibling design was used, and Cox regression was used to assess the relationship between parental and perinatal factors and the risk of subsequent stress-related diseases

In population analysis, 55,511 were diagnosed with stress-related diseases, and sibling analysis determined 37,433 were diagnosed with stress-related diseases
.

diagnosis

In population-based analysis, it was observed that mothers / fathers were younger than 25 years old, single mothers, parity ≥ 4 times, body mass index ≥ 25, or mothers smoking during early pregnancy, gestational diabetes, and moderate preterm delivery (GA 32-36 Weeks ) or younger gestational age offspring have an increased risk of stress-related diseases
.

These associations were significantly reduced to zero in the sibling analysis

It has been observed that mother / father age <25 years old, single mother, parity ≥4 times, body mass index ≥25, or mother smoking during early pregnancy, gestational diabetes and moderate preterm diabetes (GA 32-36 weeks ), or small gestational age Offspring are at increased risk of stress-related diseases

The results of this study indicate that most of the associations between parental and perinatal factors and stress-related disease risk observed in population analysis are driven by a common family environment or genetics, and emphasize the importance of the etiology of mental illness.
The importance of family design in epidemiological research
.

Most of the associations between parental and perinatal factors and stress-related disease risk observed in population analysis are driven by a common family environment or genetics, and emphasized in the epidemiological study of the etiology of mental illness The importance of home design
.

Most of the associations between parental and perinatal factors and stress-related disease risk observed in population analysis are driven by a common family environment or genetics, and emphasized in the epidemiological study of the etiology of mental illness The importance of home design

Li, Y.

Li, Y.
, Sjölander, A.
, Song, H.
  et al.
 Associations of parental and perinatal factors with subsequent risk of stress-related disorders: a nationwide cohort study with sibling comparison.
  Mol Psychiatry  (2022).
https:// doi.
org/10.
1038/s41380-021-01406-5 Li, Y.
, Sjölander, A.
, Song, H.
  et al.
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