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Front.aging-neurosci-FGF21 regulates microglia polarization and attenuates neurodegeneration in mice and cell models of Parkinson’s disease

 Last Update: 2022-01-08
 Source: Internet
 Author: User

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Parkinson's disease (PD) is an age-related neurodegenerative disease characterized by chronic degeneration of midbrain dopaminergic neurons

Research results 1.

In order to test the therapeutic potential of FGF21, the PD group and FGF21 group were injected with MPTP-HCL intraperitoneally for 1 week, and the control group was injected with saline

FGF21 significantly reduced the gene expression of M1 microglia markers IL-1β, TNF-α and CD 68 (Figure 2A)

LPS was used to induce BV2 microglia, an in vitro model was constructed, and FGF21 treatment was used to study the mechanism of FGF21 regulating the polarization of microglia

References Changwei Yang, Wuqiong Wang, Pengxi Deng, Chen Li, Liangcai Zhao and Hongchang Gao, Fibroblast Growth Factor 21 Modulates Microglial Polarization That Attenuates Neurodegeneration in Mice and Cellular Models of Parkinson's Disease, Front.

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