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Click on the blue letters to focus on the advanced functions of our cerebral cortex such as executive decision-making, language comprehension, and sensory perception
.
Cortical excitatory and inhibitory neurons are derived from radial glial cell populations in different brain regions: progenitor cells in the cortex form excitatory neurons, and interneurons are formed from progenitor cells in the ganglion bulge, and then migrate to the cortex
.
Studies have shown that human cortical progenitor cells can form excitatory neurons and glial cells
.
On December 15, 2021, Tomasz J.
Nowakowski, Department of Anatomy, University of California, discovered that by developing a molecular barcode tool to track the differentiation of radial glial cells, it was found that human cortical progenitor cells can differentiate into inhibitory neurons
.
STICR technology tracks human neuron development.
Researchers use lentiviruses containing fluorescent markers and DNA "barcode" sequences to permanently label cells and their progeny, and then perform high-throughput sequencing technology on these cells with unique "barcode" labels.
Tracking, this technology is called STICR technology, which can mark 250,000 different cells, and the probability of marking the same cell is 5 out of 1,000
.
They used human brain tissue samples from 15 and 18 weeks of gestation combined with STICR technology to trace the lineage of human cortical progenitor cells.
After 6 weeks, these progenitor cells can differentiate into excitatory neurons and inhibitory neurons
.
Of the 1461 DNA "barcode" tags identified, 91% belong to multiple cell clone lineages (each lineage contains about 23 cells on average, and the largest clone lineage contains 1209 cells).
The relationship was sorted out and found that about 829 of these multiple cell clone lineages contained at least one excitatory neuron, and only 19 lineages contained only excitatory neurons.
.
Surprisingly, there are excitatory neurons, inhibitory neurons, and glial cells in 635 cloned lineages, which indicates that excitatory neurons and inhibitory nerves may share ancestors
.
Even more surprising is that cortical progenitor cells produce at least two main subtypes of interneurons: one is transcriptionally similar to olfactory bulb interneurons, and the other is similar to cortical interneurons
.
They transplanted human-derived progenitor cells labeled with STICR technology into the cortex of immunodeficient mice in the early postnatal period, and the final lineage tracing results were consistent with the above-mentioned in vitro cell experiment
.
Previous animal experiments have shown that excitatory neurons and inhibitory neurons are derived from different progenitor cells
.
However, this article uses the latest molecular barcode technology to reveal that excitatory neurons and inhibitory neurons can be derived from the same neural progenitor cell, breaking traditional cognition
.
[References] 1.
https://doi.
org/10.
1038/s41586-021-04230-7 The pictures in the text are from the references
.
Cortical excitatory and inhibitory neurons are derived from radial glial cell populations in different brain regions: progenitor cells in the cortex form excitatory neurons, and interneurons are formed from progenitor cells in the ganglion bulge, and then migrate to the cortex
.
Studies have shown that human cortical progenitor cells can form excitatory neurons and glial cells
.
On December 15, 2021, Tomasz J.
Nowakowski, Department of Anatomy, University of California, discovered that by developing a molecular barcode tool to track the differentiation of radial glial cells, it was found that human cortical progenitor cells can differentiate into inhibitory neurons
.
STICR technology tracks human neuron development.
Researchers use lentiviruses containing fluorescent markers and DNA "barcode" sequences to permanently label cells and their progeny, and then perform high-throughput sequencing technology on these cells with unique "barcode" labels.
Tracking, this technology is called STICR technology, which can mark 250,000 different cells, and the probability of marking the same cell is 5 out of 1,000
.
They used human brain tissue samples from 15 and 18 weeks of gestation combined with STICR technology to trace the lineage of human cortical progenitor cells.
After 6 weeks, these progenitor cells can differentiate into excitatory neurons and inhibitory neurons
.
Of the 1461 DNA "barcode" tags identified, 91% belong to multiple cell clone lineages (each lineage contains about 23 cells on average, and the largest clone lineage contains 1209 cells).
The relationship was sorted out and found that about 829 of these multiple cell clone lineages contained at least one excitatory neuron, and only 19 lineages contained only excitatory neurons.
.
Surprisingly, there are excitatory neurons, inhibitory neurons, and glial cells in 635 cloned lineages, which indicates that excitatory neurons and inhibitory nerves may share ancestors
.
Even more surprising is that cortical progenitor cells produce at least two main subtypes of interneurons: one is transcriptionally similar to olfactory bulb interneurons, and the other is similar to cortical interneurons
.
They transplanted human-derived progenitor cells labeled with STICR technology into the cortex of immunodeficient mice in the early postnatal period, and the final lineage tracing results were consistent with the above-mentioned in vitro cell experiment
.
Previous animal experiments have shown that excitatory neurons and inhibitory neurons are derived from different progenitor cells
.
However, this article uses the latest molecular barcode technology to reveal that excitatory neurons and inhibitory neurons can be derived from the same neural progenitor cell, breaking traditional cognition
.
[References] 1.
https://doi.
org/10.
1038/s41586-021-04230-7 The pictures in the text are from the references
