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Concentric sclerosis-this case will definitely give you a lot of rewards!
Time of Update: 2021-12-31
08 enhanced MRI + MRS + enhanced scan: bilateral frontal and parietal lobes, basal ganglia, corpus callosum pressure and left occipital lobe have multiple abnormal signals, the NAA value of the area of interest is reduced, and demyelinating diseases, concentric sclerosis should be considered more The possibility is high, please combine clinical and laboratory examinations .
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Express congratulations!
Time of Update: 2021-12-31
Our platform has proven that it can identify new targets for these diseases from patient data sets, and quickly integrate It is developed as a drug candidate .
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Sci Adv The steady-state plasticity of the presynaptic response to the excessive release of excitatory transmitters in the nervous system
Time of Update: 2021-12-30
Therefore, as a sensor and effector of PHD, GluClα adaptively inhibits the release of neurotransmitters by generating inhibitory signal mechanisms at the nerve presynaptic terminals .
Original link: https:// Platemaker: Notes for reprinting on the 11th [Non-original article] The copyright of this article belongs to the author of the article.
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Solve the important problem of gene therapy, the life-saving artifact can also enter the brain
Time of Update: 2021-12-30
▲Expression of vectors with different capsid proteins in brain and liver tissues (picture source: reference [3]) The study managed to track the recombinant virus with green fluorescent protein.
org/gene-therapy-turns-ten/[3] David Goertsen et al, AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset, Nature Neuroscience (2021).
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Cell Res: Shanghai University of Science and Technology Liu Zhijie/Hua Tian team reveals the signal transduction mechanism of the schizophrenia target GPR139
Time of Update: 2021-12-30
The mechanism of negative symptoms of anti-schizophrenia and the safety of opioids have always been scientific problems that need to be solved urgently . The orphan receptor GPR139 is a highly expre
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Anxiety may "brain"?
Time of Update: 2021-12-30
Picture source: 123RF Finally, the study came to the following conclusions: 1) Generally speaking, compared with people without mental illness, there is a higher level of anxiety symptoms (rather than depression symptoms) in the late middle age (51-60 years old) ), the concentration and memory may be worse .
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[Cell News] Why do pain and anxiety speed up the breathing rate?
Time of Update: 2021-12-30
Recent research has discovered a neural network that harmonizes breathing rhythms with feelings of pain and fear to explain this problem and help develop an analgesic that prevents opioid-induced respiratory depression (OIRD) .
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How to manage blood sugar to prevent and treat stroke?
Time of Update: 2021-12-29
8mmol/L) For people with a history of severe hypoglycemia, short life expectancy, severe microvascular or macrovascular complications or other serious complications, as well as a long history of diabetes and the use of multiple drugs including insulin For patients who have difficulty controlling blood sugar, consider increasing the target HbA1c level to 8.
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Spontaneous intracranial hypotension associated with frontotemporal dementia-such a case, you will never forget it after seeing it once!
Time of Update: 2021-12-29
Figure 2 Sagittal (A) and axial (B) T2-weighted MRI images after treatment show that the symptoms of intracranial hypotension have almost completely resolved .
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Beware of the misleading of family history: a classic case of brain organic disease misdiagnosed as schizophrenia
Time of Update: 2021-12-29
In a case report published in J Clin Psychiatry[1], a 59-year-old female patient was once misdiagnosed as schizophrenia due to a series of negative symptoms and a misleading "positive family history"; Olfactory groove meningioma, healed after surgical resection .
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Is obstructive sleep apnea related to white matter hyperintensity?
Time of Update: 2021-12-29
Through the analysis of WMH images, OSA and clinical data in cases, we investigated general risk factors, subclinical diseases, clinical diseases and their interrelationships .
In addition, adjusting the risk factors related to WMH, such as metabolism, blood vessels, and life>.
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Express "first-in-class" myasthenia gravis therapy is approved by FDA, Zai Lab has China development rights
Time of Update: 2021-12-29
▎The content team editor of WuXi AppTec recently, argenx announced that the US FDA has approved the "first-in-class" therapy Vyvgart (efgartigimod alfa-fcab) for the treatment of anti-acetylcholine receptor (AChR) antibody-positive systemic myasthenia gravis (GMG) Adult patients .
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Acute biparalysis with low back pain and dysfunctional stool for more than 10 days. What should I consider when viewing a film for diagnosis?
Time of Update: 2021-12-29
▌ Imaging diagnosis of spinal cord vascular malformations .
C. It is worth noting that after the bleeding is completely absorbed, the re-examination of the MRI reveals the intramedullary curved strip and beaded empty signal, which indicates the spinal vascular malformation.
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Weakness of both lower limbs + decreased vision, detailed diagnosis ideas have been summarized
Time of Update: 2021-12-29
▌ Qualitative diagnosis: young female patients, subacute onset, clinical manifestations of spinal cord and optic nerve injury symptoms, imaging findings found lesions in long segments of the spinal cord (> 3 segments), laboratory tests showed positive AQP4 antibody, combined with clinical, imaging and According to the biochemical performance, it is not difficult to diagnose the patient as neuromyelitis optica (NMO) in this case .
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From 1 to 2!
Time of Update: 2021-12-29
They found through in vitro cell experiments that melatonin can protect microglia from lipopolysaccharide-induced inflammation: inhibit the release of pro-inflammatory factors (IL-6 and TNF-α), while promoting anti-inflammatory factors (IL-4).
CAR-M-UZPM injection can inhibit pro-inflammatory factors, promote the release of anti-inflammatory factors, and significantly improve depression-like behavior disorders .
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Science's new discovery: the "transmission" of nerve impulses in white matter, astrocytes can regulate the excitability and conduction velocity of myelinated axons
Time of Update: 2021-12-29
Written | Edited by Qi | Enzyme Astrocytes support the neuronal function of the entire central nervous system . In gray matter, they regulate the number of synapses during development, remove neurot
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『BICCN Column』The establishment of Nature genetic tools-motor neuron cortical glutamatergic neuron-specific strains
Time of Update: 2021-12-29
Neural precursor cells differentiate to form radial glial progenitors (RGs), which undergo asymmetric division to produce different subgroups of glutamatergic vertebral neurons, and migrate to the motor neuron cortex in order from the inside to the outside (Picture 1) [2] .
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Nature Sub-Journal: Fighting poison with poison, the deadly anthrax toxin can be used to eliminate pain
Time of Update: 2021-12-28
The authors believe that this understanding of the interaction between anthrax toxin derivatives and pain receptors may promote the development of new research tools and the improvement of analgesic drugs .
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『BICCN column』Nature Type-specific classification of mouse motor neuron cortex
Time of Update: 2021-12-28
The Lior Pachter research group of California Institute of Technology in the BICCN consortium published a paper entitled Isoform cell-type specificity in the mouse primary motor cortex, which revealed the resolution of genotype subtypes through SMART-seq [1] and the combination with spatial transcriptome technology.
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By transforming pathogenic bacterial toxins into analgesics, Harvard scientists open the door to new treatments
Time of Update: 2021-12-28
▲Professor Isaac Chiu’s research team is committed to understanding how microbes affect pain (picture source: Harvard Medical School official website) "This molecular platform uses bacterial toxins to deliver drugs to specific neurons and regulate their functions, which represents a targeted pain nerve It’s a new way of metamorphosis .
