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The insular cortex balances the rats’ psychological and physical responses to fear｜Science Weekly Selection
Time of Update: 2021-12-06
According to a new study on mice, in the insular cortex (a leaflet folded deep in the cerebral cortex of a mammal), body feedback signals are used to counteract fear responses .
Previous studies have shown that the insular cortex (InsCtx) plays a role in processing body signals and possibly in maintaining and subtracting fear .
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To assist in the development of new drugs, the Tsinghua Lubai team developed the first rat model that fully simulates human Alzheimer's disease
Time of Update: 2021-12-06
Through a head-to-head comparison study with AppNL-GF mice, Professor Lu Bai’s team pointed out that from the persistent death of nerve cells and the resulting brain atrophy, as well as another key feature of Alzheimer’s disease, tau protein pathology, etc.
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One article to clarify the fact that repeated stimulation is clinically necessary
Time of Update: 2021-12-06
In MG patients, due to the AChR pathology of the postsynaptic membrane, even if a large amount of ACh is released during high-frequency electrical stimulation, since the combination of ACh and AChR has been saturated, the compound muscle action potential amplitude will not increase significantly .
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New breakthrough in real-time monitoring of traumatic brain injury: diffuse reflection optical technology to achieve non-invasive monitoring
Time of Update: 2021-12-06
However, current research shows that the 1064nm timed diffuse reflectance correlation spectroscopy system may become a portable, non-invasive, continuous bedside CBF monitor, which will bring good news to patients with brain injury .
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Recurrent thrombosis after cerebral infarction anticoagulation, and death a few days later, this cause is too difficult...
Time of Update: 2021-12-06
2. For occult stroke cases, if there are the following conditions: elevated D-dimer, multiple infarcts in different vascular distribution areas, and embolic events in other organs, the possibility of occult malignant tumors should be considered .
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Professor Lu Ming: Sofantinib combined with teriprizumab in the treatment of neuroendocrine cancer sings on the international stage and brings more hope to patients
Time of Update: 2021-12-06
The recent 2021 North American Society of Neuroendocrine Oncology (NANETS) annual meeting announced the latest data from the Phase II clinical study of sofatinib combined with teriprizumab in the treatment of advanced neuroendocrine cancer that failed first-line chemotherapy .
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Summary of "Collector's Edition" Nat Rev Neurosci｜Sheng Zuhang/Li Sunan summarize the important role of presynaptic local energy metabolism in nerve conduction
Time of Update: 2021-12-06
This article discusses in depth the mechanism of local energy metabolism (glycolysis and mitochondrial oxidative phosphorylation), and the important role of energy levels in maintaining and regulating the effectiveness and plasticity of synaptic transmission, and proposes synaptic energy for the first time A new concept of metabolism (Synaptoenergetics) .
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Peripheral neuropathy positioning diagnosis, 4 steps for you to easily master
Time of Update: 2021-12-06
Expert Profile Wang Yan, deputy chief physician of the Department of Cardiovascular Neurology in Neurology, Beijing Tiantan Hospital, and a master's degree from Capital Medical University, has long been engaged in clinical, scientific research and teaching of neurology, and his specialty is cerebrovascular disease .
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Neuron: Professor Hailan Hu's team analyzes the regulation mechanism of the medial prefrontal cortex microcirculation in social competitive behavior
Time of Update: 2021-12-05
Neuron competition is one of the most common social behaviors in the animal world, and it is also the cause of social hierarchy, the basic way of social organization . For groups, a stable hierarchi
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The neuSCAN team of the University of Electronic Science and Technology of China reveals the neurobiological mechanism of the human brain to represent fear emotions
Time of Update: 2021-12-05
Therefore, by comparing the similarities in the function and spatial distribution of neural response patterns, this study reveals for the first time that the acquired fear formed in the fear acquisition task and the fear emotion in the face of horror scenes may have different neural representations (Figure 4) .
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Professor Chen Jianguo/Wang Fang from Huazhong University of Science and Technology reveals that adhesion molecule α-DG regulates depression-like behavior
Time of Update: 2021-12-05
In summary, this article reveals that GLY-α-DG in the ventral hippocampus mediates the pathogenesis of depression by regulating the expression of GABAA receptors on the membrane and GABAergic synaptic transmission .
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Is it difficult to manage blood pressure in stroke patients?
Time of Update: 2021-12-05
*Only for medical professionals to read for reference to smoothly reduce blood pressure, prevent and control strokes, see how ARNI shows its magical powers in God!
How to regulate the blood pressure of stroke patients?
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STTT Xi’an Jiaotong University and other units cooperated, Hou Peng/Yang Jian/He Nongyue discovered a new potential therapeutic target for glioma
Time of Update: 2021-12-05
Further studies have shown that HACE1 activates nuclear factor red blood cell 2 related factor 2 (NFE2L2, also known as NRF2) through a variety of mechanisms, leading to enhanced malignant phenotype and decreased radiosensitivity of glioma cells .
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"Hey, touch your head~" "Nature" reveals why we comfort our companions like this
Time of Update: 2021-12-05
▲The pressure-stimulated mice received frequent grooming from their peers after returning to "home" (picture source: reference [1]) This scene took place in the laboratory of Professor Weizhe Hong at the University of California, Los Angeles (UCLA), researchers Researching why animals would comfort anxious companions .
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[Pain topic] Transforaminal epidural steroids for herpes zoster-related pain: the golden age for best results
Time of Update: 2021-12-05
Furthermore, a logistic regression analysis was performed to identify patients' factors associated with a successful treatment outcome The pain intensity changes in 3 months, the patients were divided into effective group (E group) and ineffective group (N group) .
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Not every Danish fairy tale has a happy ending
Time of Update: 2021-12-05
The study showed that, in the real world, early and high-efficiency DMT strategies have better long-term outcomes for patients than upgraded treatment strategies-the 5-year change in EDSS scores is significantly reduced, and the median time to SAD is significantly delayed .
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『BICCN Column』Nature Human neocortex expansion and glutamatergic neuron diversification
Time of Update: 2021-12-05
Written | November https:// column | General introduction: Cerebral cortex motor neuron map landscape and database alliance BICCN; "BICCN column" Nature | Compared with mice, the single-cell DNA methylation profile of mouse brain has a significant increase in the volume of the human cerebral cortex.
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The brain is also intensive learning!
Time of Update: 2021-12-05
To study how brain activity represents the details of value-based decision-making, the researchers set up reinforcement learning experiments .
The researchers explained in the paper: "These results show that although the information encoding is highly distributed, not all information represented in neural activity can be used in every area .
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How to diagnose and treat patients with Parkinson's disease who have insomnia and excessive daytime sleepiness?
Time of Update: 2021-12-05
▌ Common causes of insomnia①Influencing factors include gender, course of disease, depression and anxiety, factors that cause sleep disruption (such as nocturnal motor symptoms, mental symptoms, nocturia, pain, dystonia), and endogenous circadian rhythm disorders; ②Drugs ( Such as amantadine, selegiline), especially when used at night, may increase the risk of insomnia; ③ Dopaminergic drugs can improve night motor dysfunction, but may also worsen sleep quality .
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Express treatment of a variety of neurological diseases, about 2.6 billion US dollars to help develop selective GPCR agonists
Time of Update: 2021-12-05
▎The content team editor of WuXi AppTec recently, Neurocrine Biosciences and Sosei Heptares announced a strategic cooperation and licensing agreement to jointly develop new selective muscarinic receptor agonists for the treatment of schizophrenia, dementia and Other neurological diseases .
