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A list of recommendations for diagnosis and treatment of aneurysmal subarachnoid hemorrhage!
Time of Update: 2021-12-06
For patients with a ruptured aneurysm, endovascular treatment or craniotomy should be performed as soon as possible to reduce the risk of bleeding after aSAH .
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Treatment of Alzheimer's disease, human beings still have a long, long way to go. CTAD 2021 inventory
Time of Update: 2021-12-06
We have selected some important research results, let's take a look at ~ Tau-targeted antibodies: the results are not optimistic, Balazs Toth of Roche Genentech and others reported the top-line results of the Lauriet study (ROUNDTABLE 4) of the Phase 2 clinical trial .
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Can PM2.5 really cause neurodegenerative diseases?
Time of Update: 2021-12-06
5 is also a high-risk factor for neuroinflammation, which may cause damage to the central nervous system .
To this end, the team of Professor Hansang Cho of Sungkyunkwan University in South Korea used a 3D culture model in a microfluidic system to simulate the interaction environment between glial cells and neurons, thereby clarifying the relationship between astrocytes and microglia.
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Dannuo Medicine reports positive results of Phase II clinical trial of TNP-2092 capsules in the treatment of cirrhosis and hyperammonemia
Time of Update: 2021-12-06
The results of studies on the effects of escalation and eating have laid the foundation for the further development of later clinical studies of TNP-2092 capsules in the treatment of liver cirrhosis, hyperammonemia and hepatic encephalopathy.
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In order to save energy, humans have evolved "irregular" brain neurons Nature
Time of Update: 2021-12-06
The researchers put forward a hypothesis: this reduction in ion channel density may contribute to the efficient evolution of the human brain, enabling it to transfer resources to other energy-intensive processes required to perform complex cognitive tasks .
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Neuron｜Winner Or Loser? Professor Hailan Hu reveals the micro-loop mechanism of social competition
Time of Update: 2021-12-06
On November 18, 2021, Professor Hailan Hu's research group from Zhejiang University School of Medicine published an article revealing that the dorso-medial prefrontal cortex (dmPFC) brain area PV neurons mediated VIP neurons → pyramidal neurons to inhibit micro-loop regulation of society Victory and failure behavior in competition .
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MimiVac peptide mimic tumor vaccine received FDA approval for 2b clinical trial for the treatment of glioblastoma
Time of Update: 2021-12-06
November 19, 2021/eMedClub News/--Recently, a clinical stage biotechnology company MimiVac LLC announced , SurVaxM received the US Food and Drug Administration (FDA) approval notice in the 2b trial phase to evaluate the effectiveness of the newly diagnosed glioblastoma .
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Neuron cross-species single-cell transcriptome analysis reveals loss of new neuron generation in adult brains
Time of Update: 2021-12-06
In this study, the researchers used the hippocampal single-cell transcriptome data of adult mice in 2018, and then achieved data integration analysis of cell transcriptome across four species (human, monkey, pig, and mouse) .
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Laser + gold nanoparticles open the blood-brain barrier and make drug delivery faster
Time of Update: 2021-12-06
The researchers synthesized gold nanoparticles to specifically target tight junctions and demonstrated that transcranial picosecond laser stimulation of the nanoparticles after intravenous injection increases the permeability of the blood-brain barrier .
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About mecobalamin, you need to know at least these 5 things!
Time of Update: 2021-12-06
Recently, some doctors broke the news: because the doctors prescribed mecobalamin tablets for diabetic patients who have been taking metformin for a long time, the hospital received a huge fine from the Medical Insurance Bureau .
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Spring is here: More and more monoclonal antibodies for Alzheimer's disease enter FDA review
Time of Update: 2021-12-06
In addition to Bojian's aducanumab, the Donanemab monoclonal antibody developed by Eli Lilly also targets β-amyloid (Aβ), and it has a better effect on clearing Aβ from the brain .
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The Peking University team’s new discovery: Improve depression, may slow down the degradation of cognitive function, researcher Wu Xiang's comment
Time of Update: 2021-12-06
Source of screenshots of research introduction: Age and Ageing This study uses data from a total of 17,556 community populations in the US HRS cohort and the British ELSA cohort to explore the relationship between the trajectory of different depression symptoms and the subsequent decline in cognitive function for up to 18 years .
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Nature: A textbook discovery!
Time of Update: 2021-12-06
After activating the medial nucleus, lateral nucleus and intermediate nucleus of DCN by chemical genetics technology, only the neurons of the lateral nucleus are activated and inhibit feeding behavior (simulating the feeling of fullness), even in a rewarding high-sugar and high-fat diet Down is also inhibited; and inhibiting neurons in this area (simulating a hungry state) promotes feeding behavior .
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The pain index is over 10!
Time of Update: 2021-12-06
Case: A patient completely cured a severe and devastating migraine for more than 12 years after switching to a whole plant-based diet .
com/content/6/11/e006394 Related reading: BMJ Sub-Journal: Whole Plant-Based Diet Saved This A desperate female patient, suffering from 8 years of vascular disease, healed herself without medicine!
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Cell Res | Tsinghua University Lu Bai/Guo Wei created a rat model of Alzheimer's disease to better simulate the symptoms of human Alzheimer's disease
Time of Update: 2021-12-06
On November 17, 2021, Tsinghua University Lu Bai and Guo Wei jointly published a research paper entitled "An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments" in Cell Research.
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One of the BICCN column general topics: the cerebral cortex motor neuron map landscape and the database alliance BICCN
Time of Update: 2021-12-06
In addition, the BICCN Alliance used the MERFISH experiment to identify cell types in situ, spatial positioning, and projection analysis, and used Patch-seq to map cross-species transcriptomes and morphological-electrophysiological characteristics in the motor neuron cortex (Figure 1) .
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Research progress in brain neuroregulation and reading technology
Time of Update: 2021-12-06
Based on previous research, researchers have recently constructed a multifunctional flexible neural electrode technology, which simultaneously realizes precise delivery of gene carriers in the brain, long-term optogenetic regulation, and neuroelectrophysiological recording .
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Science reviews are amazing!
Time of Update: 2021-12-06
The research tested 16 Aldehyde (HEX, more secreted by babies), a volatile substance in the human body as a social chemical signal in mammals, will it affect the aggressiveness of humans ?
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[Science] How to regulate fear?
Time of Update: 2021-12-06
Recently, a study entitled "Fear balance is maintained by bodily feedback to the insular cortex in mice" was published in the journal Science .
Therefore, this study shows that the insular cortex needs feedback from the body to maintain fear at an appropriate level .
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Peripheral neuropathy positioning diagnosis, 4 steps for you to easily master
Time of Update: 2021-12-06
Expert Profile Wang Yan, deputy chief physician of the Department of Cardiovascular Neurology in Neurology, Beijing Tiantan Hospital, and a master's degree from Capital Medical University, has long been engaged in clinical, scientific research and teaching of neurology, and his specialty is cerebrovascular disease .
