-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Click on the blue text for more preferential information Transforaminal Epidural Steroid Injection for Zoster-Related Pain: The Golden Period for the Best OutcomePain Physician 2021; 24:E669-E676 • ISSN 2150-1149 https:External steroid injection for the treatment of herpes zoster-related pain: the golden age of best results BackgroundZoster-related pain (ZRP) has many negative effects on a patient' s quality of life.
The transforaminal steroid injection (TFESI), which reduces neural inflammation and pain , has been advocated by pain physicians.
Many reports demonstrated that early administration of TFESI showed better efficacy; however, the golden period during which TFESI is most effective remains unclear Negative impact
.
Injecting steroids (TFESI) through the intervertebral foramen can reduce neuroinflammation and pain, and has been advocated by pain physicians
.
Many reports have shown that early use of TFESI shows better efficacy.
However, the golden age of TFESI is still unclear
.
Objectives This multicentre retrospective cohort study aimed to identify the golden period by which TFESI yields the best outcome in patients with ZRP
.
MethodsAfter performing the TFESI in patients with ZRP, the patients were classified into two groups: the effective group (E) and the not effective group (N) based on the changes in the pain intensity 3 months after the TFESI.
The receiver operating characteristic ( ROC) curve analysis was used to assess the cut-off time point for predicting TFESI effectiveness.
Furthermore, a logistic regression analysis was performed to identify patients' factors associated with a successful treatment outcome The pain intensity changes in 3 months, the patients were divided into effective group (E group) and ineffective group (N group)
.
Receiver operating characteristic (ROC) curve analysis is used to evaluate the cut-off time point for predicting the efficacy of TFESI
.
In addition, a logistic regression analysis was performed to determine patient factors related to successful treatment outcome
.
Result Of the 302 patients, 186 and 116 patients were classified into the E and N group, respectively.
ROC curve analysis showed that the best cut-off time point for TFESI was 12 weeks (95% confidence interval [CI]; 10-14 weeks) after the onset of HZ.
The only variable associated with a favorable outcome was a symptom duration of ≤ 12 weeks compared with> 12 weeks (Odd ratio, 0.
107; 95% CI, 0.
055-0.
205; P <0.
001).
Other patient variables were not significantly associated with the effectiveness of TFESI.
TFESI was most effective when administered within 12 weeks of the onset of herpes zoster.
Results: Among 302 patients, 186 cases were divided into E group and 116 cases in N group
.
ROC curve analysis showed that the best cut-off point for TFESI was 12 weeks after the onset (95% confidence interval; 10-14 weeks)
.
The only variable associated with a favorable outcome was ≤ symptom duration of 12 weeks, rather than> 12 weeks (odd ratio, 0.
107; 95% CI, 0.
055-0.
205; P<0.
001)
.
Other patient variables have no significant correlation with the effectiveness of TFESI
.
TFESI is most effective when administered within 12 weeks after the onset of herpes zoster
.
Limitation This study was not a prospective randomized controlled trial (RCT) and the follow-up period was only 3 months after TFESI.
Limitation: This study was not a prospective randomized controlled trial (RCT), and the follow-up period was only 3 months after TFESI
.
Conclusion TFESI is more effective when administered within 12 weeks of onset of herpes zoster.
Conclusion: TFESI is more effective when administered within 12 weeks of onset of herpes zoster
.
RefeRences: 1.
Johnson RW, Rice AS.
Clinical practice.
Postherpetic neuralgia.
N Engl J Med 2014; 371:1526-1533.
2.
Opstelten W, Van Wijck AJ, Van Essen GA, et al.
The PINE study: rationale and design of a randomised comparison of epidural injection of local anaesthetics and steroids versus care-as-usual to prevent postherpetic neuralgia in the elderly [ISRCTN32866390].
BMC Anesthesiol 2004; 4:2.
3.
Kang DH, Kim SY, Kim HG, Park JH, Kim TK , Kim KH.
Earlier treatment improves the chances of complete relief from postherpetic neuralgia.
Korean J Pain 2017; 30:214-2194.
Kim ED, Bak HH, Jo DH, Park HJ.
Clinical efficacy of transforaminal epidural injection for management of zo5.
Ster-associated pain: a retrospective analysis.
Skeletal Radiol 2018; 47:253-260.
Doo AR, Choi JW, Lee JH, et al.
The efficacy of selective nerve root block for the long-term outcome of postherpetic neuralgia.
Korean J Pain 2019; 32:215-222.
Literature collation and translation: Poi Jin Xiansen
.
Typesetting: Ding Dong Wan Zi Ma Get the original text Backstage reply "Shingles" Scan the code to follow us and study hard
The transforaminal steroid injection (TFESI), which reduces neural inflammation and pain , has been advocated by pain physicians.
Many reports demonstrated that early administration of TFESI showed better efficacy; however, the golden period during which TFESI is most effective remains unclear Negative impact
.
Injecting steroids (TFESI) through the intervertebral foramen can reduce neuroinflammation and pain, and has been advocated by pain physicians
.
Many reports have shown that early use of TFESI shows better efficacy.
However, the golden age of TFESI is still unclear
.
Objectives This multicentre retrospective cohort study aimed to identify the golden period by which TFESI yields the best outcome in patients with ZRP
.
MethodsAfter performing the TFESI in patients with ZRP, the patients were classified into two groups: the effective group (E) and the not effective group (N) based on the changes in the pain intensity 3 months after the TFESI.
The receiver operating characteristic ( ROC) curve analysis was used to assess the cut-off time point for predicting TFESI effectiveness.
Furthermore, a logistic regression analysis was performed to identify patients' factors associated with a successful treatment outcome The pain intensity changes in 3 months, the patients were divided into effective group (E group) and ineffective group (N group)
.
Receiver operating characteristic (ROC) curve analysis is used to evaluate the cut-off time point for predicting the efficacy of TFESI
.
In addition, a logistic regression analysis was performed to determine patient factors related to successful treatment outcome
.
Result Of the 302 patients, 186 and 116 patients were classified into the E and N group, respectively.
ROC curve analysis showed that the best cut-off time point for TFESI was 12 weeks (95% confidence interval [CI]; 10-14 weeks) after the onset of HZ.
The only variable associated with a favorable outcome was a symptom duration of ≤ 12 weeks compared with> 12 weeks (Odd ratio, 0.
107; 95% CI, 0.
055-0.
205; P <0.
001).
Other patient variables were not significantly associated with the effectiveness of TFESI.
TFESI was most effective when administered within 12 weeks of the onset of herpes zoster.
Results: Among 302 patients, 186 cases were divided into E group and 116 cases in N group
.
ROC curve analysis showed that the best cut-off point for TFESI was 12 weeks after the onset (95% confidence interval; 10-14 weeks)
.
The only variable associated with a favorable outcome was ≤ symptom duration of 12 weeks, rather than> 12 weeks (odd ratio, 0.
107; 95% CI, 0.
055-0.
205; P<0.
001)
.
Other patient variables have no significant correlation with the effectiveness of TFESI
.
TFESI is most effective when administered within 12 weeks after the onset of herpes zoster
.
Limitation This study was not a prospective randomized controlled trial (RCT) and the follow-up period was only 3 months after TFESI.
Limitation: This study was not a prospective randomized controlled trial (RCT), and the follow-up period was only 3 months after TFESI
.
Conclusion TFESI is more effective when administered within 12 weeks of onset of herpes zoster.
Conclusion: TFESI is more effective when administered within 12 weeks of onset of herpes zoster
.
RefeRences: 1.
Johnson RW, Rice AS.
Clinical practice.
Postherpetic neuralgia.
N Engl J Med 2014; 371:1526-1533.
2.
Opstelten W, Van Wijck AJ, Van Essen GA, et al.
The PINE study: rationale and design of a randomised comparison of epidural injection of local anaesthetics and steroids versus care-as-usual to prevent postherpetic neuralgia in the elderly [ISRCTN32866390].
BMC Anesthesiol 2004; 4:2.
3.
Kang DH, Kim SY, Kim HG, Park JH, Kim TK , Kim KH.
Earlier treatment improves the chances of complete relief from postherpetic neuralgia.
Korean J Pain 2017; 30:214-2194.
Kim ED, Bak HH, Jo DH, Park HJ.
Clinical efficacy of transforaminal epidural injection for management of zo5.
Ster-associated pain: a retrospective analysis.
Skeletal Radiol 2018; 47:253-260.
Doo AR, Choi JW, Lee JH, et al.
The efficacy of selective nerve root block for the long-term outcome of postherpetic neuralgia.
Korean J Pain 2019; 32:215-222.
Literature collation and translation: Poi Jin Xiansen
.
Typesetting: Ding Dong Wan Zi Ma Get the original text Backstage reply "Shingles" Scan the code to follow us and study hard
