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STTT Xi’an Jiaotong University and other units cooperated, Hou Peng/Yang Jian/He Nongyue discovered a new potential therapeutic target for glioma
Time of Update: 2021-12-05
Further studies have shown that HACE1 activates nuclear factor red blood cell 2 related factor 2 (NFE2L2, also known as NRF2) through a variety of mechanisms, leading to enhanced malignant phenotype and decreased radiosensitivity of glioma cells .
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How to distinguish between Parkinson's disease dementia and Lewy body dementia?
Time of Update: 2021-12-05
Among them, the diagnostic criteria of PDD mainly refer to the "Diagnostic Criteria and Treatment Guidelines for Parkinson's Disease Dementia" updated in 2021, which was published in the Chinese Journal of Neurology in August 2021.
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Clinical features of acute cerebral infarction MRI, super complete summary
Time of Update: 2021-12-05
01 A 56-year-old female patient with cortical watershed infarction was admitted to the hospital with the main complaint of "inoperable left limb for 3 days" .
02 A 74-year-old female patient with subcortical watershed infarction was admitted to the hospital with the main complaint of "inoperable right limbs for 3 days" .
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Which lifestyle is likely to cause the onset of Parkinson's disease?
Time of Update: 2021-12-05
Early studies have shown that drinking coffee, taking aspirin, and smoking can affect the age of onset of Parkinson's disease (PD) and the degree of clinical symptoms .
➤The age of onset of patients who took aspirin was 5 years later-64.
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Drugs for treating hemifacial spasm, 2 tables make it clear!
Time of Update: 2021-12-05
The main treatment methods include drugs, botulinum toxin injections, and surgery (microvascular decompression) .
Commonly used drugs for the treatment of hemifacial spasm include carbamazepine, oxcarbazepine, and diazepam .
Therefore, botulinum toxin injection cannot be used as a long-term treatment for hemifacial spasm .
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Nature Neuroscience: Scientists reveal that ventral striatum subregions regulate self-cleaning behavior
Time of Update: 2021-12-05
Click on the blue word to pay attention to our striatum (including the olfactory tubercle) as a key component of the cortex-basal ganglia circuit, which regulates movement, participates in goal motivation and reward motivation behavior, and is mainly composed of GABAergic medium spiny neurons.
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NEJM: This rare disease that died before the age of 10 was repaired by lentiviral gene therapy
Time of Update: 2021-12-05
Eight children with Hurler syndrome received autologous hematopoietic stem or progenitor cell therapy.
5 years old at the time of these treatments received autologous hematopoietic stem and progenitor cell (HSPC) transplants .
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Lost in the supermarket?
Time of Update: 2021-12-05
▲The urban scene seen by volunteers (picture source: reference [2]) According to the brain electrical activity displayed by MRI, the researchers found that the brain usually has completely different response measures when searching for different information, and it will learn new ones.
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NgAgo is completely useless of scientific research value?
Time of Update: 2021-12-05
On November 8, 2021, Liu Yan and Guan Tuchen of Nantong University published a research paper entitled "Cadherin-12 Regulates Neurite Outgrowth Through the PKA/Rac1/Cdc42 Pathway in Cortical Neurons" in Frontiers in Cell and Developmental Biology.
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Should a 90-year-old patient with acute cerebral infarction and gastrointestinal hemorrhage be treated with thrombolysis?
Time of Update: 2021-12-05
This patient is not only a super-aged patient, but also received adequate intravenous thrombolysis when there is contraindication to gastrointestinal bleeding, and good results have been achieved.
There has been a case report of a 54-year-old man with recent upper gastrointestinal bleeding who was given adequate rt-PA thrombolysis and obtained a good prognosis.
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"Nature": The cerebellum is actually a balancer between dry rice and long meat!
Time of Update: 2021-12-05
According to fMRI results, the deep cerebellar nuclei are related to appetite control (dogs and cakes look like real ones) To determine the role of DCN in regulating food intake, Betley and her colleagues performed DCN neuronal activity in mice And eating conditions were tested .
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Reappear the dawn!
Time of Update: 2021-12-05
Recently, the Brigham and Women's Hospital affiliated to Harvard Medical School announced that it will take the lead in conducting the first human clinical trial of Alzheimer's disease vaccine, aiming to evaluate a nasal spray immunotherapy candidate drug called Protollin to prevent or slow down the disease Effectiveness of progress .
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"Orphan drug" RGX-202 uses a new AAV vector to treat patients with Duchenne muscular dystrophy
Time of Update: 2021-12-05
RGX-202 is designed to use REGENXBIO's proprietary NAV AAV8 vector (a vector used in many clinical trials) and a well-characterized muscle targeting promoter (Spc5-12) to support the delivery and targeted expression of genes throughout the bone and myocardium .
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Parkinson's syndrome ≠ Parkinson's disease-a clarification of the differential diagnosis of Parkinson's syndrome
Time of Update: 2021-12-05
In the new clinical diagnostic criteria for Parkinson’s disease by the Society for Movement Disorders (MDS), the reduction in amplitude or speed in repetitive motion is emphasized, and this reduction is usually not seen in progressive supranuclear palsy (PSP) or other atypical Parkinson’s syndrome Levy .
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IHC2021: Prevention of migraine, the first head-to-head study of CGRP new target drugs and traditional drugs
Time of Update: 2021-12-05
Sensitivity analysis showed that compared with topiramate group, the proportion of patients with MMD reduction ≥50% in Erenumab group was significantly higher (at the first month, 23.
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The latest research shows that drinking more coffee can reduce the risk of Alzheimer's disease
Time of Update: 2021-12-05
Samantha Gardener, pointed out that the survey results showed that there is an association between coffee intake and several important biomarkers related to Alzheimer's disease .
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Neuron: Support the mental health and productivity of the laboratory
Time of Update: 2021-12-05
The laboratory should establish an overall high-level structure to support all laboratory members through clear expectations, guidelines and project plans; encourage and respect the sense of boundary; strengthen the guidance relationship and promote a safe and collaborative laboratory culture to promote experiments Positive interpersonal communication indoors (Figure 1) .
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The imaging characteristics of ischemic stroke in the super-acute phase, one article to understand
Time of Update: 2021-12-05
In the hyperacute phase, rapid identification of patients, elimination of non-ischemic stroke neurological diseases, and clarification of the infarct area will help determine the next treatment plan as soon as possible .
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Cell Metab Microbial Acetate A New Mechanism for Regulating Health and Alzheimer’s Disease Brain Immune Cell Metabolism
Time of Update: 2021-12-05
Figure 6 The number of microglia and Aβ in the brain of 5xFAD mice treated with acetate were the same as those in the SPF group (Source: Erny D et al.
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The diagnosis and treatment of Parkinson's disease freezing gait, look at the latest expert consensus!
Time of Update: 2021-12-05
Treatment of frozen gait (1) Recommendations for drug therapy: Rasagiline can be used as an adjuvant therapy for FOG (A2 level of evidence).
Levodopa is the drug of choice for the treatment of FOG in Parkinson's disease (level B evidence) .
