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Experts comment on Protein & Cell overturning the classic theory, and Li Xiaojiang's team reveals a new mechanism for hereditary Parkinson's disease
Time of Update: 2021-12-05
This study uses gene-edited monkey models and dead human brain tissue to deeply study the expression and function of Parkinson’s disease-causing gene PINK1, overturning the long-standing classic theory based on in vitro and small animal experiments, and providing a treatment for Parkinson’s disease.
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The WeiLi Research Group of Pennsylvania State University AS: The mechanism of the liquid-liquid separation structure formed by the side spot protein NONO and TAZ protein in the carcinogenesis of glioma
Time of Update: 2021-12-05
Innovation: The Wei Li research group of the Hershey Medical Research Center of Pennsylvania State University used the BioID biotin intracellular protein labeling technology to identify and analyze the key protein NONO that interacts with the core transcriptional activator protein TAZ of the Hippo signaling pathway .
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Nat Metab︱ Tang Qiqun/Qian Shuwen’s team found that M2 macrophages promote thermogenesis of adipose tissue through sympathetic nerves
Time of Update: 2021-12-05
The study found that M2 macrophages in adipose tissue secrete Slit3 protein, which binds to the receptor Robo1 on the sympathetic nerve, activates the Ca2+/CaMKⅡ pathway to promote norepinephrine secretion, thereby increasing fat cell catabolism and heat production, and improving mice The cold tolerance .
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Review of 2021 ECTRIMS Conference Hot Spots: A comprehensive inventory of the efficacy and safety of Sinimod for different SPMS groups, not to be missed!
Time of Update: 2021-12-05
One of the extended studies used the hierarchical structure retention time-to-failure model (RPSFT) to analyze the continuous use of sinimod treatment compared with the model simulated virtual placebo (LTVP) and placebo-to-sinimod treatment (LTPS) groups Patients in the (LTCS) group were based on the 6-month assessment of EDSS to confirm the differences in the risk of disability progression (6mCDP) and the time to progression, and subgroup analysis was performed based on disease activity .
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Personalized T cell immunotherapy for pediatric brain tumors is one step closer to becoming a reality
Time of Update: 2021-12-05
In order to find immunotherapies that may bring hope to these young patients, scientists at the National Children's Hospital in Washington, DC used a specific type of DNA analysis to design a new therapy that has shown promising efficacy in preclinical studies .
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JAMA Sub-Journal: The latest research from Harvard University shows that you often use Douyin and beware of depression
Time of Update: 2021-12-04
Recently, Harvard University, the Massachusetts General Hospital of Harvard Medical School, Northwestern University, University of Pennsylvania and other research institutions have cooperated and published the title: Association Between Social Media Use and Self-reported Symptoms of Depression in the JAMA Network Open journal.
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Nature: Lu Bai's team at Tsinghua University has developed the world's first rat model that fully simulates human Alzheimer's disease
Time of Update: 2021-12-04
Recently, the renowned neuroscientist, professor at Tsinghua University's School of Pharmacy, Lu white leadership team to achieve a major breakthrough in the field, to fully simulate the successful development of gene knock-rat model of Alzheimer's disease, related to the results of a few days ago to Article The format is published online in the Cell Research journal .
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Stroke: The effect of deferoxamine on the outcome of patients based on hematoma volume
Time of Update: 2021-12-04
Heart blood vesselsAccording to the post-hoc analysis of the intracerebral hemorrhage deferoxamine treatment trial (i-DEF); participants were classified according to baseline hematoma volume (small <10 mL, medium 10-30 mL, large> 30 mL) .
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JAHA: Incidence and long-term outcome of stroke in patients with ST-segment elevation myocardial infarction
Time of Update: 2021-12-04
Incidence and Long‐Term Outcomes of Stroke in Patients Presenting With ST‐Segment Elevation--Myocardial Infarction: Insights From the Midwest STEMI Consortium .
022489Incidence and Long-Term Outcomes of Stroke in Patients Presenting With ST-Segment Elevation-Myocardial Infarction: Insights From the Midwest STEMI Consortium in this message
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Frontiers in Aging Neuroscience: The latest research shows that drinking more coffee can reduce the risk of Alzheimer's disease
Time of Update: 2021-12-04
Recently, researchers Edith Cowan University, Australia, in Frontiers in Aging Neuroscience journal published a study entitled: Higher Coffee Consumption Associated With Slower Cognitive Decline Is is and A [beta]-Less Cerebral Amyloid Accumulation Over 126 Months: the From the Data at The Australian Research papers on Imaging, Biomarkers, and Life> .
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Professor Zhao Xingquan: Early stroke blood pressure control (1): Early blood pressure management before and in the hospital
Time of Update: 2021-12-04
RCT for antihypertensive in the acute phase of cerebral infarctionCOSSACS study: 763 patients (mainly ischemic stroke, 5% primary cerebral hemorrhage) were randomly divided into two groups: one group continued to receive antihypertensive drugs 2 weeks after the stroke, and the other group suspended antihypertensive drugs After 2 weeks, the systolic blood pressure of the continued medication group was reduced by 13 mmHg compared with the discontinuation group, but there was no difference in the incidence of primary endpoint events .
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JAHA: Insomnia, smoking, high blood pressure, beware of ruptured brain aneurysms!
Time of Update: 2021-12-04
Brain aneurysm (cerebral aneurysm) in the brain is due to the arterial vessel wall fragility and other reasons, such that the vascular wall inherent nodular form a similar object, so called cerebral a
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Drug treatment of adult migraine, 3 tables give you the answer
Time of Update: 2021-12-04
Recommended over-the-counter analgesics for acute migraine attacks in adultsTable 1.
Recommendations of over-the-counter analgesics for acute migraine attacks in adults Table 2.
Recommendations of over-the-counter analgesics for acute migraine attacks in adults Table 2.
migraine prevention treatment drugs recommended in Table 3.
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Migraine, tension headache, hypertensive headache...One article teaches you to identify 10 types of headaches
Time of Update: 2021-12-04
Because these two types of drugs have a strong vasoconstrictor effect, and long-term large-scale use can cause serious adverse consequences, therefore, for patients with moderate to severe headaches who have taken non-steroidal anti-inflammatory drugs (NSAIDs) in the past, they can continue to be given NSAIDs.
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Schizophrenia case interpretation Lurasidone treatment of paranoid schizophrenia
Time of Update: 2021-12-04
The patient Wang Moumou, male, 27 years old, went to the outpatient clinic on July 8, 2021 because of "hearing people's words out of thin air, the suspect followed up for the persecution for July, which was aggravated by 2 weeks" .
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New research finds: lack of sleep when young is devastating to the brain
Time of Update: 2021-12-04
Recently, researchers from Harvard Medical School and Boston Children's Hospital published a research paper titled: Shorter Duration and Lower Quality Sleep Have Widespread Detrimental Effects on Developing Functional Brain Networks in Early Adolescence in Cerebral Cortex Communications .
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Hypertension: blood pressure level and risk of dementia
Time of Update: 2021-12-04
Diagnosis and management to prevent vascular diabetes and cholesterolRecently, a research article was published in Hypertension, an authoritative cardiovascular journal, in which researchers investigated the association between blood pressure and the risk of dementia subtypes through antihypertensive treatment and comorbidities .
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The latest data of the new AAV9-mediated RNA targeting system is released, which can correct the molecular and functional defects of type 1 myotonic muscular dystrophy Yi Mai Meng broke the news
Time of Update: 2021-12-04
▲ DM1 disease development process (picture source: Locanabio official website) The modular RNA binding protein system developed by the CorRECTX™ platform can modify RNA through a variety of mechanisms, such as cutting, splicing, gene replacement, translation enhancement and editing .
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Stroke is not a "stroke" too late to prevent!
Time of Update: 2021-12-04
StrokeStroke occurs when the blood flow to the human brain is obstructed , including vascular obstruction (ischemic stroke) and blood vessel rupture (hemorrhagic stroke) .
What are the high risk factors for stroke?Is there any way to effectively help me and my family to prevent stroke?
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How to evaluate the efficacy of clopidogrel-aspirin for cerebral ischemia?
Time of Update: 2021-12-04
published a paper in the international authoritative medical journal STROKE, assessing whether age, body mass index, chronic kidney disease, diabetes and genotyping (ABCD-GENE) score can predict clopidogrel in mild stroke or The curative effect in patients with transient ischemic attack [4], let's take a look at today's news!
